{"id":111666,"date":"2011-03-11T00:00:00","date_gmt":"2011-03-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genetico-de-la-va%c2%ada-erk-mapk-en-el-desarrollo-y-mantenimiento-de-tumores-de-pulmon-promovidos-por-k-ras-g12v\/"},"modified":"2011-03-11T00:00:00","modified_gmt":"2011-03-11T00:00:00","slug":"analisis-genetico-de-la-va%c2%ada-erk-mapk-en-el-desarrollo-y-mantenimiento-de-tumores-de-pulmon-promovidos-por-k-ras-g12v","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genetico-de-la-va%c2%ada-erk-mapk-en-el-desarrollo-y-mantenimiento-de-tumores-de-pulmon-promovidos-por-k-ras-g12v\/","title":{"rendered":"\u00aban\u00e1lisis gen\u00e9tico de la v\u00edaerk-mapk en el desarrollo y mantenimiento de tumores de pulm\u00f3n promovidos por k-ras g12v\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Blasco Pati\u00f1o <\/strong><\/h2>\n<p>Hemos( estudiado el( papel( de( cada( miembro( de la( cascada( raf\/mek\/erk( en( la( iniciaci\u00f3n( de( tumores de pulm\u00f3n(de(c\u00e9lulas(no(peque\u00f1as, inducidos(por(la(expresi\u00f3n(de(una(forma(oncog\u00e9nica(de(k ras.( La( eliminaci\u00f3n( de( erk1( o( erk2, en( c\u00e9lulas( que( expresaban esta( forma( oncog\u00e9nica( de( k as,( no( afectaba( a( la( iniciaci\u00f3n( tumoral debido( a( la( compensaci\u00f3n( entre( ambas( isoformas.( Sin( embargo,( la( eliminaci\u00f3n( de( ambas( quinasas( erk( imped\u00eda( completamente( el( desarrollo( de( estos( tumores.( Similares( resultados se(obtuvieron(para las(quinasas(mek. Por(otro( lado,(no( se(observ\u00f3( compensaci\u00f3n(entre( las( quinasas( raf.( Mientras( que( la( eliminaci\u00f3n( de( b af no( ten\u00eda consecuencias( en( el( desarrollo( de( los( tumores,(la(expresi\u00f3n(de(c af(era(esencial(para(la(aparici\u00f3n(de(estos(tumores.(La(eliminaci\u00f3n(conjunta( de( c af( y( b af,( en( ratones( adultos,( no( conllevaba( efectos( delet\u00e9reos( para( la( homeostasis( de( los( animales.( Estos resultados( indican( que( c af( juega( un( papel( imprescindible( en( la( mediaci\u00f3n( de( las( se\u00f1ales(oncog\u00e9nicas(de k as(en(este(tipo(de(tumores,(con(lo(que(podr\u00eda(ser(una(diana(para(el(desarrollo( de(terapias(antitumorales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00aban\u00e1lisis gen\u00e9tico de la v\u00edaerk-mapk en el desarrollo y mantenimiento de tumores de pulm\u00f3n promovidos por k-ras g12v\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00aban\u00e1lisis gen\u00e9tico de la v\u00edaerk-mapk en el desarrollo y mantenimiento de tumores de pulm\u00f3n promovidos por k-ras g12v\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Blasco Pati\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/11\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Barbacid Montalb\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Miguel angel Santos de dios <\/li>\n<li>angel Rodriguez nebreda (vocal)<\/li>\n<li>Manuel Serrano marug\u00e1n (vocal)<\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Blasco Pati\u00f1o Hemos( estudiado el( papel( de( cada( miembro( de la( cascada( raf\/mek\/erk( en( la( iniciaci\u00f3n( [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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