{"id":112137,"date":"2018-03-11T10:39:00","date_gmt":"2018-03-11T10:39:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/a-prominent-role-of-mmp-10-in-atherosclerosis-associated-with-vascular-calcification\/"},"modified":"2018-03-11T10:39:00","modified_gmt":"2018-03-11T10:39:00","slug":"a-prominent-role-of-mmp-10-in-atherosclerosis-associated-with-vascular-calcification","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/a-prominent-role-of-mmp-10-in-atherosclerosis-associated-with-vascular-calcification\/","title":{"rendered":"A prominent role of mmp-10 in atherosclerosis associated with vascular calcification"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Purroy L\u00f3pez <\/strong><\/h2>\n<p>We have investigated the role of metalloproteinase-10 (mmp-10) in the atherothrombotic process, using in vivo and in vitro experimental approaches, and explored its possible association with vascular calcification.  aortic mmp-10 expression was observed in the atherosclerotic lesion of apolipoprotein e-\/- (apoe-\/-), but not in the healthy vascular wall of wild type mice, colocalizing with macrophage-like cells. In apoe-\/- mice, lack of functional mmp-10 was associated with reduced lesion size in three different vascular beds, less vascular calcification, plaque rupture and macrophage content, and increased vascular smooth muscle cells, indicating a more stable plaque phenotype. we have also shown that mmp-10 is involved in human atherosclerosis: human atherosclerotic plaques express and secrete mmp-10 to the medium, particularly calcified atheromas. Circulating mmp-10 levels are associated with coronary calcium in subclinical atherosclerosis, a marker of cardiovascular risk. Chronic kidney disease patients present increased serum mmp-10 levels associated with the severity of atherosclerosis and vascular calcification.  in vitro, mmp-10 accelerates endothelial wound healing by promoting human ecs migration and proliferation. Proinflammatory stimuli induce mmp-10 expression in endothelium, macrophages and vsmcs. Finally, we have demonstrated that while aortic vsmcs from mmp-10 deficient mice exhibit reduces calcium deposition, mmp-10 induces a calcifying phenotype in murine and human vsmcs. in summary, these findings reveal that mmp-10 plays a crucial role in different stages of the atherosclerotic process by promoting plaque inflammation and increased calcification. circulating mmp-10 concentration may represent a new risk marker of atherosclerosis, a predictor of cardiovascular events.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>A prominent role of mmp-10 in atherosclerosis associated with vascular calcification<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 A prominent role of mmp-10 in atherosclerosis associated with vascular calcification <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Purroy L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Paramo Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas De la osada Garc\u00eda <\/li>\n<li>olivier gabriel Meilhac (vocal)<\/li>\n<li>Ana Fortu\u00f1o gil (vocal)<\/li>\n<li>Fernando Civeira murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Purroy L\u00f3pez We have investigated the role of metalloproteinase-10 (mmp-10) in the atherothrombotic process, using [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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