{"id":112158,"date":"2018-03-11T10:39:00","date_gmt":"2018-03-11T10:39:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/terapia-celular-con-celulas-madre-derivadas-del-tejido-adulto-en-un-modelo-murino-de-ictus-mediante-oclusion-de-la-arteria-cerebral-media\/"},"modified":"2018-03-11T10:39:00","modified_gmt":"2018-03-11T10:39:00","slug":"terapia-celular-con-celulas-madre-derivadas-del-tejido-adulto-en-un-modelo-murino-de-ictus-mediante-oclusion-de-la-arteria-cerebral-media","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cultivo-celular\/terapia-celular-con-celulas-madre-derivadas-del-tejido-adulto-en-un-modelo-murino-de-ictus-mediante-oclusion-de-la-arteria-cerebral-media\/","title":{"rendered":"Terapia celular con c\u00e9lulas madre derivadas del tejido adulto en un modelo murino de ictus mediante oclusi\u00f3n de la arteria cerebral media"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Mora Lee <\/strong><\/h2>\n<p>Stroke models are essential tools in experimental stroke.  Although several models of stroke have been developed in a variety of animals, with the development of transgenic mice there is the need to develop a reliable and reproducible stroke model mice, which mimics as close as possible human stroke. stroke represents an attractive target of stem cell therapy and although different types of cells have been employed in animal models, a direct comparison between cells sources has not been performed. the aim of our study was to compare the effect of human multipotent stem cells (hmapcs) and human mesenchymal stem cells (hmscs) and to determine the mechanism involved in tissue repair. balb\/ca-rag2-\/- c\/-&#612;c\/- mice were subjected to cauterization or thrombosis stroke and sacrificed at different time points (48 hr, 1 wk, 2 wk and 4wk) after stroke. Mice received brdu  to estimated activation of cell proliferation in the svz. Brains were processed for immunohistochemical an em. balb\/ca-rag2-\/- c\/-&#612;c\/- mice were subjected to fecl3 thrombosis stroke model were intracranially injected with 2 x 105  hmapcs or hmscs 2 days after stroke and followed for up to 28 days. our results provide an exhaustive analysis of the histophatological changes that occur after stroke in the ischemic boundary zone, which are of key importance for the final stroke outcome. transplantation of hmscs and hmapcs produced greater brain integrity preservation as determined by the decreased loss of tissue mediated by several mechanisms. interestingly, these neuroprotective effects were more pronounced in the group of animals treated with hmapcs  in comparison with hmscs. Our results establish cell therapy with hmapcs  in comparison with hmscs. Our results establish cell therapy with hmapcs and hmscs  as a promising strategy for treatment of stroke.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia celular con c\u00e9lulas madre derivadas del tejido adulto en un modelo murino de ictus mediante oclusi\u00f3n de la arteria cerebral media<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia celular con c\u00e9lulas madre derivadas del tejido adulto en un modelo murino de ictus mediante oclusi\u00f3n de la arteria cerebral media <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Mora Lee <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2011<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felipe Luis Prosper Cardoso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Garcia verdugo <\/li>\n<li>Mar\u00eda salom\u00e9 Sirerol piquer (vocal)<\/li>\n<li>josune Orbe lopategui (vocal)<\/li>\n<li>Jaime G\u00e1llego culler\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Mora Lee Stroke models are essential tools in experimental stroke. Although several models of stroke have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,17749],"tags":[18255,70738,16726,89520,122579,223252],"class_list":["post-112158","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-navarra","tag-felipe-luis-prosper-cardoso","tag-jaime-gallego-cullere","tag-jose-manuel-garcia-verdugo","tag-josune-orbe-lopategui","tag-maria-salome-sirerol-piquer","tag-silvia-mora-lee"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112158"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112158\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}