{"id":112325,"date":"2012-06-02T00:00:00","date_gmt":"2012-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-y-funcion-de-las-proteinas-hedgehog-en-el-timo-humano\/"},"modified":"2012-06-02T00:00:00","modified_gmt":"2012-06-02T00:00:00","slug":"expresion-y-funcion-de-las-proteinas-hedgehog-en-el-timo-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expresion-y-funcion-de-las-proteinas-hedgehog-en-el-timo-humano\/","title":{"rendered":"Expresi\u00f3n y funci\u00f3n de las proteinas hedgehog en el timo humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Cruz Gutierrez De Frias <\/strong><\/h2>\n<p>En conjunto, los resultados que se exponen en el presente trabajo demuestran por primera vez que la v\u00eda de se\u00f1alizaci\u00f3n hh est\u00e1 activa en el timo humano adulto. Los progenitores t\u00edmicos cd34  que colonizan el timo, expresan el componente de se\u00f1alizac i\u00f3n hh durante las etapas m\u00e1s tempranas de su desarrollo, lo que les convierte en diana de la prote\u00edna shh producida por el epitelio medular y subcapsular. Este estadio coincide con aquel que presenta sensibilidad a ciertas interleucinas, entre las q ue se encuentran sdf-1 e il-7, siendo este \u00faltimo el principal factor de crecimiento producido por el epitelio t\u00edmico humano, con efectos positivos en supervivencia, proliferaci\u00f3n y diferenciaci\u00f3n t. La prote\u00edna hh induce en los timocitos en diferenc iaci\u00f3n una p\u00e9rdida de sensibilidad a estas mol\u00e9culas, contrarrestando su actividad y reteni\u00e9ndoles en un estadio indiferenciado, contribuyendo de esta forma al mantenimiento de una poblaci\u00f3n celular de progenitores intrat\u00edmicos y a la homeostasis del  \u00f3rgano. Los datos presentados en este trabajo aportan evidencias de que la actividad de otros componentes clave del timo, las c\u00e9lulas dendr\u00edticas, tambi\u00e9n est\u00e1 regulada por la v\u00eda de se\u00f1alizaci\u00f3n hh.  \thasta la fecha no se podido demostrar que shh s e comporte como un morf\u00f3geno en el timo humano, estableciendo gradientes de concentraci\u00f3n funcionales tal y como est\u00e1 descrito en otros tejidos. Sin embargo, un patr\u00f3n diferencial en la producci\u00f3n de la prote\u00edna, as\u00ed como la expresi\u00f3n por parte de la s dcs y las c\u00e9lulas epiteliales de diferentes moduladores con capacidad para unir hh, podr\u00eda contribuir a la aparici\u00f3n de m\u00faltiples microambientes en el timo, en los que diferentes concentraciones de shh podr\u00edan afectar de forma distinta, tanto cuant itativa como cualitativamente, a poblaciones celulares t\u00edmicas que presenten diversos grados de sensibilidad a hh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n y funci\u00f3n de las proteinas hedgehog en el timo humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n y funci\u00f3n de las proteinas hedgehog en el timo humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Cruz Gutierrez De Frias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Varas Fajardo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>Ana Mar\u00eda Mart\u00edn moreno (vocal)<\/li>\n<li>silvia S\u00e1nchez ram\u00f3n (vocal)<\/li>\n<li>rosa m. Y\u00e1\u00f1ez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Cruz Gutierrez De Frias En conjunto, los resultados que se exponen en el presente trabajo demuestran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,986],"tags":[6521,202784,194592,223517,67625,38642],"class_list":["post-112325","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-complutense-de-madrid","tag-agustin-gregorio-zapata-gonzalez","tag-alberto-varas-fajardo","tag-ana-maria-martin-moreno","tag-maria-cruz-gutierrez-de-frias","tag-rosa-m-yanez-gonzalez","tag-silvia-sanchez-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112325"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112325\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}