{"id":112374,"date":"2018-03-11T10:39:20","date_gmt":"2018-03-11T10:39:20","guid":{"rendered":""},"modified":"2018-03-11T10:39:20","modified_gmt":"2018-03-11T10:39:20","slug":"papel-de-caveolina-1-en-la-transduccion-de-senalesregulacion-del-ciclo-celular-dependiente-de-integrinas-y-generacion-de-un-nuevo-modelo-murino-de-expresion-de-caveolina-1-no-fosforilable-cav1-y14f","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-de-caveolina-1-en-la-transduccion-de-senalesregulacion-del-ciclo-celular-dependiente-de-integrinas-y-generacion-de-un-nuevo-modelo-murino-de-expresion-de-caveolina-1-no-fosforilable-cav1-y14f\/","title":{"rendered":"Papel de caveolina-1 en la transducci\u00f3n de se\u00f1ales:regulaci\u00f3n del ciclo celular dependiente de integrinas y generaci\u00f3n de un nuevo modelo murino de expresi\u00f3n de caveolina -1 no fosforilable (cav1-y14f)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Carmen Guadamillas Mora <\/strong><\/h2>\n<p>Resumen tesis marta c. Guadamillas mora      la prote\u00edna cav1, adem\u00e1s de ser clave en la formaci\u00f3n de caveolas, participa en la transducci\u00f3n y modulaci\u00f3n de diversas rutas de se\u00f1alizaci\u00f3n, estando por tanto implicada en la regulaci\u00f3n de multitud de p rocesos. En esta tesis doctoral se ha profundizado en el estudio del papel de cav1 en la regulaci\u00f3n del ciclo celular, y m\u00e1s en detalle, en la proliferaci\u00f3n dependiente de adhesi\u00f3n a matriz extracelular (mec), mediada por integrinas. Mediante el uso de diversas l\u00edneas celulares deficientes en cav1, se ha podido demostrar que cav1 modula el arresto del ciclo celular en condiciones desfavorables, como son la falta de nutrientes o la p\u00e9rdida de adhesi\u00f3n a sustrato. Esta regulaci\u00f3n implica la activa ci\u00f3n de las v\u00edas de rac y pi3k-akt-gsk3?, Siendo independiente de erk. Cav1 est\u00e1 regulando la internalizaci\u00f3n de microdominios de membrana espec\u00edficos (cemms) donde se compartimentan mol\u00e9culas clave de estas rutas de se\u00f1alizaci\u00f3n, que son silenciadas  tras la p\u00e9rdida de adhesi\u00f3n por integrinas. Tanto la ausencia de cav1 como la incapacidad de ser fosforilada en su residuo tirosina-14 (y14) llevan a la desregulaci\u00f3n de la internalizaci\u00f3n de cemms tras la p\u00e9rdida de adhesi\u00f3n a sustrato, permanecien do activas las rutas de rac y pi3k-akt, lo que permite la supervivencia y progresi\u00f3n del ciclo celular independientemente de adhesi\u00f3n por integrinas.      adem\u00e1s se ha generado y validado un nuevo modelo murino knock-in cav1y\/y  que permite el estudi o del papel de la fosforilaci\u00f3n de cav1 en y14 en concreto, a un nivel fisiol\u00f3gico y sist\u00e9mico. En este tesis doctoral se ha abordado la caracterizaci\u00f3n del fenotipo cardiaco de estos ratones<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de caveolina-1 en la transducci\u00f3n de se\u00f1ales:regulaci\u00f3n del ciclo celular dependiente de integrinas y generaci\u00f3n de un nuevo modelo murino de expresi\u00f3n de caveolina -1 no fosforilable (cav1-y14f)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de caveolina-1 en la transducci\u00f3n de se\u00f1ales:regulaci\u00f3n del ciclo celular dependiente de integrinas y generaci\u00f3n de un nuevo modelo murino de expresi\u00f3n de caveolina -1 no fosforilable (cav1-y14f) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Carmen Guadamillas Mora <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Cerezo Montemayor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Perez gil <\/li>\n<li>vicente Andr\u00e9s Garc\u00eda (vocal)<\/li>\n<li>david Santamar\u00eda velilla (vocal)<\/li>\n<li>borja Iba\u00f1ez cabeza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Carmen Guadamillas Mora Resumen tesis marta c. Guadamillas mora la prote\u00edna cav1, adem\u00e1s de ser clave [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,986],"tags":[54119,204708,146814,25839,223597,66951],"class_list":["post-112374","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-complutense-de-madrid","tag-ana-cerezo-montemayor","tag-borja-ibanez-cabeza","tag-david-santamaria-velilla","tag-jesus-perez-gil","tag-marta-carmen-guadamillas-mora","tag-vicente-andres-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112374"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112374\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}