{"id":112446,"date":"2012-02-03T00:00:00","date_gmt":"2012-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genomotipificacion-de-campylobacter-jejuni-mediante-microarrays-de-adn-analisis-de-marcadores-y-diversidad-genetica\/"},"modified":"2012-02-03T00:00:00","modified_gmt":"2012-02-03T00:00:00","slug":"genomotipificacion-de-campylobacter-jejuni-mediante-microarrays-de-adn-analisis-de-marcadores-y-diversidad-genetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-veterinaria\/genomotipificacion-de-campylobacter-jejuni-mediante-microarrays-de-adn-analisis-de-marcadores-y-diversidad-genetica\/","title":{"rendered":"Genomotipificaci\u00f3n de campylobacter jejuni mediante microarrays de adn. an\u00e1lisis de marcadores y diversidad gen\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andrea Guridi Cortaberria <\/strong><\/h2>\n<p>Campylobacter jejuni es una de las principales causas de diarrea bacteriana a nivel mundial y el antecedente m\u00e1s com\u00fan en neuropat\u00edas perif\u00e9ricas como el s\u00edndrome guillain barr\u00e9 y miller fisher. Determinar las diferentes fuentes de infecci\u00f3n de campylobacter ha sido un objetivo largamente perseguido por gobiernos, instituciones y cient\u00edficos en los \u00faltimos a\u00f1os. A pesar de todos los esfuerzos, las contribuciones realizadas no permiten determinar con exactitud las diferentes fuentes de infecci\u00f3n, lo cual ha dificultado el establecimiento de estrategias eficaces de control para reducir la presencia de c. Jejuni en la cadena alimentaria. M\u00e1s recientemente, el inter\u00e9s se ha volcado en la utilizaci\u00f3n del genoma completo ya que la secuenciaci\u00f3n del mismo ha permitido el desarrollo de microarrays que permiten estudiar multitud de genes, simult\u00e1neamente. Debido a todo esto, la finalidad del trabajo fue determinar el grado de variabilidad (diversidad y\/o posible plasticidad) gen\u00f3mica entre cepas de campylobacter jejuni procedentes de diversas \u00e1reas geogr\u00e1ficas y diferentes fuentes de aislamiento, al objeto de detectar posibles genes que pueda emplearse como marcadores gen\u00e9ticos. Para ello, nuestros objetivos espec\u00edficos fueron los siguientes: 1. Determinar las condiciones experimentales m\u00e1s adecuadas para la hibridaci\u00f3n en el microarray de adn, asegurando la reproducibilidad entre ensayos, minimizando la presencia de hibridaciones cruzadas y asegurando la discriminaci\u00f3n entre las se\u00f1ales de fluorescencia para los genes presentes y los ausentes o divergentes. 2. Confeccionar una colecci\u00f3n multigeogr\u00e1fica de cepas de c. Jejuni que incluya aislamientos no clonales, seg\u00fan alelos de la regi\u00f3n svr (short variable region) del gen flaa, aislados en muestras humanas y de pollo. 3. Analizar la colecci\u00f3n de cepas seleccionadas mediante cgh (comparative genomic hybridization) utilizando microarrays de adn (genoma universal), con el fin de encontrar posibles marcadores predictivos.4. Determinar el grado de variabilidad y estructura gen\u00e9tica que presentan las cepas seleccionadas mediante m\u00e9todos bayesianos de inferencia filogen\u00e9tica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genomotipificaci\u00f3n de campylobacter jejuni mediante microarrays de adn. an\u00e1lisis de marcadores y diversidad gen\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genomotipificaci\u00f3n de campylobacter jejuni mediante microarrays de adn. an\u00e1lisis de marcadores y diversidad gen\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andrea Guridi Cortaberria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rodrigo Alonso Monsalve<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>teresa Garcia lacarra (vocal)<\/li>\n<li>Mar\u00eda isabel Gonz\u00e1lez alonso (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Figueras salvat (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andrea Guridi Cortaberria Campylobacter jejuni es una de las principales causas de diarrea bacteriana a nivel mundial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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