{"id":112553,"date":"2018-03-11T10:39:36","date_gmt":"2018-03-11T10:39:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biofilm-de-streptococcus-pneumoniae-genetica-composicion-y-terapia\/"},"modified":"2018-03-11T10:39:36","modified_gmt":"2018-03-11T10:39:36","slug":"biofilm-de-streptococcus-pneumoniae-genetica-composicion-y-terapia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/biofilm-de-streptococcus-pneumoniae-genetica-composicion-y-terapia\/","title":{"rendered":"Biofilm de streptococcus pneumoniae: gen\u00e9tica, composici\u00f3n y terapia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Domenech Lucas <\/strong><\/h2>\n<p>Se ha estimado que los biofilmes est\u00e1n implicados en m\u00e1s de la mitad de las infecciones bacterianas humanas y, hasta en un 80 , en las infecciones cr\u00f3nicas. Adem\u00e1s, las infecciones causadas por bacterias pat\u00f3genas asociadas a la formaci\u00f3n de biofilme s se muestran refractarias tanto a los agentes antimicrobianos como a los mecanismos de defensa del sistema inmunitario del hospedador. Todo ello nos ha llevado a plantear la necesidad de desarrollar nuevas v\u00edas de investigaci\u00f3n en bacterias de impor tancia cl\u00ednica relevante como es el caso de s. Pneumoniae. Hasta el momento, el modo de vida s\u00e9sil de s. Pneumoniae apenas ha sido investigado y, sin embargo, la otitis media, y, posiblemente, la neumon\u00eda y la meningitis son enfermedades neumoc\u00f3cicas  asociadas a la formaci\u00f3n de biofilmes. en esta tesis hemos concluido que, la formaci\u00f3n del biofilm es un proceso multifactorial en el que intervienen genes implicados en muy diversas funciones celulares. Adem\u00e1s de genes del metabolismo de carbohidra tos y s\u00edntesis de poliaminas, se describe por primera vez, la implicaci\u00f3n de la prote\u00edna phte (candidata para una nueva vacuna proteica) en el desarrollo de un biofilm neumoc\u00f3cico. La metalopeptidasa de membrana spr0607 parece estar implicada en la f ormaci\u00f3n del biofilm. Esta enzima parece catalizar la hidr\u00f3lisis de una o m\u00e1s prote\u00ednas de la matriz del biofilm controlando as\u00ed la cantidad de prote\u00ednas extracelulares necesarias para la formaci\u00f3n y mantenimiento del biofilm. Las cepas tolerantes a vancomicina forman un menor biofilm. La deficiencia de lyta, el fondo gen\u00e9tico y la expresi\u00f3n\/regulaci\u00f3n del sistema ciarh pueden explicar la menor formaci\u00f3n de biofilm de estas cepas tolerantes a vancomicina. los biofilmes del serotipo 3 presentan u na notable heterogeneidad debida a la coexistencia de bacterias capsuladas y mutantes no capsulados. Estos \u00faltimos podr\u00edan desempe\u00f1ar un papel esencial en las etapas iniciales del desarrollo del biofilm. en general, el polisac\u00e1rido capsular puede con stituir una barrera f\u00edsica que impide o, al menos, dificulta, las primeras etapas de formaci\u00f3n del biofilm. No obstante, la estructura qu\u00edmica del polisac\u00e1rido capsular influye en la formaci\u00f3n del biofilm ya que, dentro del mismo serogrupo capsular, se ha observado que los neumococos de los serotipos 19a y 19f son buenos formadores de biofilm mientras que los de serotipos 19b y 19c no. la matriz del biofilm neumoc\u00f3cico contiene adn-e mientras que el arn es un componente minoritario. Las prote\u00edna<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biofilm de streptococcus pneumoniae: gen\u00e9tica, composici\u00f3n y terapia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biofilm de streptococcus pneumoniae: gen\u00e9tica, composici\u00f3n y terapia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Domenech Lucas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miriam Moscoso Naya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: covadonga V\u00e1zquez est\u00e9vez <\/li>\n<li>diego Francisco Romero hinojosa (vocal)<\/li>\n<li>i\u00f1igo Lasa uzcudun (vocal)<\/li>\n<li>rubens L\u00f3pez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Domenech Lucas Se ha estimado que los biofilmes est\u00e1n implicados en m\u00e1s de la mitad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,986],"tags":[79534,123641,55916,223873,223874,5723],"class_list":["post-112553","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-complutense-de-madrid","tag-covadonga-vazquez-estevez","tag-diego-francisco-romero-hinojosa","tag-inigo-lasa-uzcudun","tag-miriam-domenech-lucas","tag-miriam-moscoso-naya","tag-rubens-lopez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112553"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112553\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}