{"id":112587,"date":"2018-03-11T10:39:36","date_gmt":"2018-03-11T10:39:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-marbofloxacino-en-conejo\/"},"modified":"2018-03-11T10:39:36","modified_gmt":"2018-03-11T10:39:36","slug":"estudio-farmacocinetico-de-marbofloxacino-en-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/estudio-farmacocinetico-de-marbofloxacino-en-conejo\/","title":{"rendered":"Estudio farmacocin\u00e9tico de marbofloxacino en conejo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luisa Francisca Alamo Fernandez <\/strong><\/h2>\n<p>Se ha estudiado el comportamiento cin\u00e9tico de marbofloxacino en conejos tras su administraci\u00f3n por las v\u00edas intravenosa, intramuscular y subcut\u00e1nea a la dosis de 2 mg\/kg, con el fin de establecer los par\u00e1metros farmacocin\u00e9ticos en esta especie. la determinaci\u00f3n de este antibi\u00f3tico en plasma se realiz\u00f3 mediante hplc con detecci\u00f3n fluorim\u00e9trica, siguiendo el m\u00e9todo descrito por siefert y cols. (1999a). El ajuste a modelos farmacocin\u00e9ticos compartimentales se realiz\u00f3 mediante el programa multifit (proost, 1997). El criterio utilizado para determinar cu\u00e1l era la ecuaci\u00f3n que mejor describ\u00eda la evoluci\u00f3n de los datos experimentales en cada caso, fue el criterio de informaci\u00f3n de akaike (aic) (yamaoka y cols., 1978). Para la determinaci\u00f3n de los par\u00e1metros no compartimentales se utiliz\u00f3 el programa winnonlin professional. marbofloxacino, tras la administraci\u00f3n intravenosa, intramuscular y subcut\u00e1nea se distribuye seg\u00fan un modelo bicompartimental abierto. tras la administraci\u00f3n intravenosa, la vida media obtenida (t1\/2?Z) fue de          8.88 \u00c2\u00b1 0,14 horas con un tiempo medio de residencia (mrt) de 4.74 \u00c2\u00b1 0,71 horas. Los vol\u00famenes aparentes de distribuci\u00f3n de marbofloxacino calculados en funci\u00f3n del \u00e1rea bajo la curva (vz) y en estado estacionario (vss) resultaron ser de 4.87 \u00c2\u00b1 1.20 l\/kg y 1,99 \u00c2\u00b1 0,27 l\/kg respectivamente, indicando una amplia distribuci\u00f3n org\u00e1nica. Por lo que respecta al aclaramiento plasm\u00e1tico (cl), \u00e9ste alcanz\u00f3 un valor de                             0,42 \u00c2\u00b1 0,04 l\/kg\u00c2\u00b7h. por v\u00eda extravascular, marbofloxacino muestra una buena absorci\u00f3n, registr\u00e1ndose tiempos de vida media de la fase de disposici\u00f3n lenta de 7.38 \u00c2\u00b1 1.30 y 6.50 \u00c2\u00b1 1.48 horas tras las administraci\u00f3n intramuscular y subcut\u00e1nea, respectivamente. la biodisponibilidad fue elevada para las dos v\u00edas extravasculares, alcanzando valores del 123.30 \u00c2\u00b1 17.64 % para la v\u00eda intramuscular y del 114,81 \u00c2\u00b1 12.11 % para la v\u00eda subcut\u00e1nea. se determinaron las concentraciones m\u00ednimas inhibitorias de marbofloxacino frente a cepas de staphylococcus aureus a fin de determinar los \u00edndices farmacocin\u00e9tico-farmacodin\u00e1micos \u00f3ptimos. De dicho estudio se puede concluir que una dosis de 2 mg\/kg de marbofloxacino no ser\u00eda efectiva por v\u00eda intramuscular o subcut\u00e1nea en conejo contra los aislados bacterianos testados en el presente estudio (cmi = 16 y 1 \u00c2\u00b5g\/ml).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocin\u00e9tico de marbofloxacino en conejo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocin\u00e9tico de marbofloxacino en conejo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luisa Francisca Alamo Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Mar\u00edn Carrillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  manuel Serrano caballero <\/li>\n<li>pilar Almela rojo (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 del rosario Bovaira Garc\u00eda (vocal)<\/li>\n<li>Juan  Manuel Serrano rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luisa Francisca Alamo Fernandez Se ha estudiado el comportamiento cin\u00e9tico de marbofloxacino en conejos tras su administraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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