{"id":112697,"date":"2018-03-11T10:39:48","date_gmt":"2018-03-11T10:39:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/terapia-celular-para-el-tratamiento-de-la-enfermedad-de-alzheimer-angiogenesis-terapeutica-inducida-por-celulas-microencapsuladas-secretoras-del-factor-de-crecimiento-del-endotelio-vascular\/"},"modified":"2018-03-11T10:39:48","modified_gmt":"2018-03-11T10:39:48","slug":"terapia-celular-para-el-tratamiento-de-la-enfermedad-de-alzheimer-angiogenesis-terapeutica-inducida-por-celulas-microencapsuladas-secretoras-del-factor-de-crecimiento-del-endotelio-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/terapia-celular-para-el-tratamiento-de-la-enfermedad-de-alzheimer-angiogenesis-terapeutica-inducida-por-celulas-microencapsuladas-secretoras-del-factor-de-crecimiento-del-endotelio-vascular\/","title":{"rendered":"Terapia celular para el tratamiento de la enfermedad de alzheimer: angiog\u00e9nesis terap\u00e9utica inducida por c\u00e9lulas microencapsuladas secretoras del factor de crecimiento del endotelio vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aitziber Portero Landa <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha estudiado el potencial del vegf como posible tratamiento para la enfermedad de alzheimer empleando como punto de partida la hip\u00f3tesis vascular. La administraci\u00f3n de dicho factor neurotr\u00f3fico se realiz\u00f3 mediante la tecnolog\u00eda de encapsulaci\u00f3n de c\u00e9lulas encapsulando fibroblastos secretores de vegf en microc\u00e1psulas de alginato. Inicialmente se realiz\u00f3 un estudio in vitro y a continuaci\u00f3n las microc\u00e1psulas se implantaron, mediante una craneotom\u00eda, sobre la corteza cerebral de ratones c57bl\/6 para comprobar su potencial angiog\u00e9nico in vivo. Finalmente, las microc\u00e1psulas se implantaron sobre la corteza cerebral de ratones app\/ps1 (considerados un modelo murino de la enfermedad). En estos ratones se realizaron distintos ensayos para comprobar si el efecto angiog\u00e9nico del vegf se traduc\u00eda en una mejora de la evoluci\u00f3n de la enfermedad y tambi\u00e9n para estudiar el efecto neurog\u00e9nico del vegf. En los ratones app\/ps1 pudo demostrarse que el efecto angiog\u00e9nico era capaz de reducir la los niveles de \u00edY-amiloide y prote\u00edna tau fosforilada mejorando tanto la supervivencia neuronal como el estado cognitivo de los ratones. Tambi\u00e9n se observ\u00f3 que el vegf era capaz de estimular la formaci\u00f3n de nuevas neuronas en el hipocampo.Con los resultados obtenidos puede concluirse que el vegf puede ser una buena alternativa para tratar la enfermedad de alzheimer y que la tecnolog\u00eda de encapsulaci\u00f3n de c\u00e9lulas es un sistema adecuado para su liberaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia celular para el tratamiento de la enfermedad de alzheimer: angiog\u00e9nesis terap\u00e9utica inducida por c\u00e9lulas microencapsuladas secretoras del factor de crecimiento del endotelio vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia celular para el tratamiento de la enfermedad de alzheimer: angiog\u00e9nesis terap\u00e9utica inducida por c\u00e9lulas microencapsuladas secretoras del factor de crecimiento del endotelio vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aitziber Portero Landa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/05\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gorka Orive Arroyo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Mari\u00f1o hernandez <\/li>\n<li>Antonio Rabasco alvarez (vocal)<\/li>\n<li>cecilia Fernandez lastra (vocal)<\/li>\n<li>eva Carro d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aitziber Portero Landa En la presente tesis doctoral se ha estudiado el potencial del vegf como posible [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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