{"id":1127,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/estudio-de-la-asociacion-del-sistema-hla-con-la-respuesta-a-la-vacuna-de-la-hepatitis-b\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"estudio-de-la-asociacion-del-sistema-hla-con-la-respuesta-a-la-vacuna-de-la-hepatitis-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-asociacion-del-sistema-hla-con-la-respuesta-a-la-vacuna-de-la-hepatitis-b\/","title":{"rendered":"Estudio de la asociacion del sistema hla con la respuesta a la vacuna de la hepatitis b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Alcaide Jimenez <\/strong><\/h2>\n<p>La adquisicion de anticuerpos frente al antigeno de superficie del virus de la hepatitis b (hbsag) es considerada una medida protectora frente a la infeccion por dicho virus. La reciente aparicion de vacunas frente a la hepatitis b compuestas de hbsag, y su extensa aplicacion en diferentes poblaciones humanas ha revelado la existencia de un peque\u00f1o porcentaje de individuos \u00abno respondedores a la vacuna\u00bb, que no producen anticuerpos especificos frente a ese antigeno.  utilizando tecnicas de tipaje serologico y de rflp de los antigenos hla de clase i y ii se ha comprobado que la falta de respuesta inmune humoral al hbsag en la poblacion espa\u00f1ola se encuentra asociada al sistema hla, principalmente a la subregion hla-dq.  la asignacion de secuencias de dna y aminoacidos de los alelos asociados indica que la falta de respuesta observada se encuentra asociada a la presencia de alanina en la posicion 57 de la cadena dq beta. Por otro lado, la distribucion de esta alanina en la poblacion de individuos no respondedores permite afirmar que la no respuesta al hbsag se hereda con caracter recesivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la asociacion del sistema hla con la respuesta a la vacuna de la hepatitis b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la asociacion del sistema hla con la respuesta a la vacuna de la hepatitis b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Alcaide Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Arnaiz Villena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Manuel Ort\u00edz De Land\u00e1zuri Busca (vocal)<\/li>\n<li>Jos\u00e9 Ramon Regueiro  Gonzalez Barros (vocal)<\/li>\n<li>Alfredo Boutello Gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Alcaide Jimenez La adquisicion de anticuerpos frente al antigeno de superficie del virus de la hepatitis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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