{"id":112719,"date":"2018-03-11T10:39:48","date_gmt":"2018-03-11T10:39:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-nuevos-analogos-de-ligandos-de-receptores-d2-que-incorporan-una-unidad-dicarba-closo-dodecaborano-marcaje-con-carbono-11-y-evaluacion-ex-vivo-e-in-vivo\/"},"modified":"2018-03-11T10:39:48","modified_gmt":"2018-03-11T10:39:48","slug":"desarrollo-de-nuevos-analogos-de-ligandos-de-receptores-d2-que-incorporan-una-unidad-dicarba-closo-dodecaborano-marcaje-con-carbono-11-y-evaluacion-ex-vivo-e-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/desarrollo-de-nuevos-analogos-de-ligandos-de-receptores-d2-que-incorporan-una-unidad-dicarba-closo-dodecaborano-marcaje-con-carbono-11-y-evaluacion-ex-vivo-e-in-vivo\/","title":{"rendered":"Desarrollo de nuevos an\u00e1logos de ligandos de receptores d2 que incorporan una unidad dicarba-closo-dodecaborano: marcaje con carbono-11 y evaluaci\u00f3n ex vivo e in vivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Naiara Vazquez Martinez <\/strong><\/h2>\n<p>La imagen molecular es una disciplina que aglutina un conjunto de t\u00e9cnicas noinvasivas que permiten la visualizaci\u00f3n de las funciones celulares y el seguimiento delos procesos moleculares en organismos vivos. La tomograf\u00eda por emisi\u00f3n depositrones (pet) es una de las t\u00e9cnicas m\u00e1s sensibles y espec\u00edficas existentes, que sebasa en la administraci\u00f3n de compuestos marcados con radionucleidos emisores depositrones (generalmente de vida media corta).El presente trabajo de tesis doctoral describe la s\u00edntesis y posterior evaluaci\u00f3nex vivo e in vivo de una familia de an\u00e1logos de ligandos de receptores dopamin\u00e9rgicosy cannabinoides.En primer lugar se describen las estrategias utilizadas para la funcionalizaci\u00f3nde una unidad dicarba-closo-dodecaborano con el fin de sintetizar una peque\u00f1a librer\u00edade ligandos: an\u00e1logos de la racloprida, un ligando antagonista de receptoresdopamin\u00e9rgicos d2, y an\u00e1logos del rimonabant, un ligando antagonista de receptorescannabinoides cb1. Se ha explorado la estabilidad de los ligandos dopamin\u00e9rgicossintetizados as\u00ed como la posible formaci\u00f3n de enlaces de hidr\u00f3geno intramolecularesen este tipo de estructuras.En segundo lugar se describe la aplicaci\u00f3n de los an\u00e1logos de ligandosdopamin\u00e9rgicos en el campo de la imagen molecular. Por un lado, se utiliza la t\u00e9cnicade la autorradiograf\u00eda ex vivo para estudiar la afinidad de los diferentes ligandosdopamin\u00e9rgicos hacia los receptores d2. Por otro lado, se describe la estrategiasint\u00e9tica utilizada para el marcaje con carbono-11 de ligandos dopamin\u00e9rgicos y suposterior evaluaci\u00f3n in vivo para estudiar su biodistribuci\u00f3n.En conclusi\u00f3n, se ha llevado a cabo el proceso completo de dise\u00f1o, s\u00edntesis,caracterizaci\u00f3n y evaluaci\u00f3n (ex vivo e in vivo) de an\u00e1logos de ligandosdopamin\u00e9rgicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de nuevos an\u00e1logos de ligandos de receptores d2 que incorporan una unidad dicarba-closo-dodecaborano: marcaje con carbono-11 y evaluaci\u00f3n ex vivo e in vivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de nuevos an\u00e1logos de ligandos de receptores d2 que incorporan una unidad dicarba-closo-dodecaborano: marcaje con carbono-11 y evaluaci\u00f3n ex vivo e in vivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Naiara Vazquez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Llop Roig<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando pedro Cossio mora <\/li>\n<li>ivan Pe\u00f1uelas sanchez (vocal)<\/li>\n<li>paolo Quadrelli &#8212; (vocal)<\/li>\n<li>francesc Teixidor bombardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Naiara Vazquez Martinez La imagen molecular es una disciplina que aglutina un conjunto de t\u00e9cnicas noinvasivas que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[87469,12909,14703],"tags":[80095,13659,18244,208242,224140,224141],"class_list":["post-112719","post","type-post","status-publish","format-standard","hentry","category-compuestos-de-boro","category-pais-vasco-euskal-herriko-unibertsitatea","category-radioquimica","tag-fernando-pedro-cossio-mora","tag-francesc-teixidor-bombardo","tag-ivan-penuelas-sanchez","tag-jordi-llop-roig","tag-naiara-vazquez-Martinez","tag-paolo-quadrelli"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112719"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112719\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}