{"id":112784,"date":"2012-08-06T00:00:00","date_gmt":"2012-08-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-geneticos-moleculares-y-celulas-implicadas-en-la-aceptacion-del-injerto-hepatico-relevancia-de-las-moleculas-coestimuladoras-cd86-y-pro-apoptoticas-cd95-y-cd95l\/"},"modified":"2012-08-06T00:00:00","modified_gmt":"2012-08-06T00:00:00","slug":"factores-geneticos-moleculares-y-celulas-implicadas-en-la-aceptacion-del-injerto-hepatico-relevancia-de-las-moleculas-coestimuladoras-cd86-y-pro-apoptoticas-cd95-y-cd95l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/factores-geneticos-moleculares-y-celulas-implicadas-en-la-aceptacion-del-injerto-hepatico-relevancia-de-las-moleculas-coestimuladoras-cd86-y-pro-apoptoticas-cd95-y-cd95l\/","title":{"rendered":"Factores gen\u00e9ticos, moleculares y c\u00e9lulas implicadas en la aceptaci\u00f3n del injerto hep\u00e1tico: relevancia de las mol\u00e9culas coestimuladoras (cd86) y pro-apopt\u00f3ticas (cd95 y cd95l)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Alberto Marin Rubio <\/strong><\/h2>\n<p>Palabras clave: inmunolog\u00eda, trasplante hep\u00e1tico, tolerancia, rechazo, mol\u00e9culas coestimuladoras, apoptosis, cd86, cd28, cd95, cd95l, interleucinas.    el objetivo principal del presente trabajo de tesis es profundizar en el conocimiento de los mecanismos inmunol\u00f3gicos implicados en el desarrollo de tolerancia o rechazo en los receptores de un injerto hep\u00e1tico. Para ello se realiz\u00f3 un estudio multifactorial que contemplara factores inmunol\u00f3gicos del receptor pre- post-trasplante, factores gen\u00e9ticos, patolog\u00eda de base, edad, sexo o tratamiento inmunosupresor. entre los hallazgos mas relevantes del presente trabajo cabe destacar c\u00f3mo el polimorfismo gen\u00e9tico del receptor en las mol\u00e9culas implicadas en la respuesta alog\u00e9nica (cd86, cd95) y citocinas como il-6 e il-10 puede condicionar la aceptaci\u00f3n del injerto hep\u00e1tico. Asimismo, los niveles en el periodo pretrasplante de ciertos factores solubles (cd86s y cd95ls) parecen influir en la evoluci\u00f3n del injerto hep\u00e1tico. Adem\u00e1s, describimos un nuevo m\u00e9todo citom\u00e9trico que permite estudiar la cin\u00e9tica de proliferaci\u00f3n y apoptosis en cultivo mixto linfocitario y as\u00ed confirmar los hallazgos detectados in vivo por citometr\u00eda de flujo.  summary: the main objective of this study is to deep in the knowledge of the immunological mechanisms implicated in the development of tolerance and rejection in liver transplant receptors. In this sense, they were analized the immunological factors of the receptor in the pre and post- transplants period, primary indication for liver transplant, genetic factors, sex , and immunosuppressive treatment. among the most relevant findings of this study include how the gene polymorphism of the receptor in those molecules involved in immune response (cd86, cd95) and cytokines such as il-6 and il-10 could condition the liver graft acceptance. Moreover, the levels in the pre-transplant period of certain soluble factors (cd86s and cd95ls) could influence in the liver transplant outcome. In addition, we described a new cytometric method that allow the study of the kinetics of proliferation and apoptosis in mixed lymphocyte cultures letting us to confirm those results obtained in vivo by flow cytometry methods.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores gen\u00e9ticos, moleculares y c\u00e9lulas implicadas en la aceptaci\u00f3n del injerto hep\u00e1tico: relevancia de las mol\u00e9culas coestimuladoras (cd86) y pro-apopt\u00f3ticas (cd95 y cd95l)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores gen\u00e9ticos, moleculares y c\u00e9lulas implicadas en la aceptaci\u00f3n del injerto hep\u00e1tico: relevancia de las mol\u00e9culas coestimuladoras (cd86) y pro-apopt\u00f3ticas (cd95 y cd95l) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Alberto Marin Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/06\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Miras Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Solana lara <\/li>\n<li>Mar\u00eda del pilar Garc\u00eda pe\u00f1arrubia (vocal)<\/li>\n<li>alfredo Minguela puras (vocal)<\/li>\n<li>marcos Gonzalez diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Alberto Marin Rubio Palabras clave: inmunolog\u00eda, trasplante hep\u00e1tico, tolerancia, rechazo, mol\u00e9culas coestimuladoras, apoptosis, cd86, cd28, cd95, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,1737,8235,2953],"tags":[93755,224245,224246,9663,8670,3760],"class_list":["post-112784","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-inmunologia","category-murcia","category-trasplante-de-organos","tag-alfredo-minguela-puras","tag-luis-alberto-marin-rubio","tag-manuel-miras-lopez","tag-marcos-gonzalez-diaz","tag-maria-del-pilar-garcia-penarrubia","tag-rafael-solana-lara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112784"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112784\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}