{"id":112802,"date":"2012-12-06T00:00:00","date_gmt":"2012-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-de-la-respuesta-al-tratamiento-con-benznidazol-en-pacientes-con-enfermedad-de-chagas\/"},"modified":"2012-12-06T00:00:00","modified_gmt":"2012-12-06T00:00:00","slug":"monitorizacion-de-la-respuesta-al-tratamiento-con-benznidazol-en-pacientes-con-enfermedad-de-chagas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/parasitologia-humana\/monitorizacion-de-la-respuesta-al-tratamiento-con-benznidazol-en-pacientes-con-enfermedad-de-chagas\/","title":{"rendered":"Monitorizaci\u00f3n de la respuesta al tratamiento con benznidazol en pacientes con enfermedad de chagas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jose Mu\u00f1oz Davila <\/strong><\/h2>\n<p>En este estudi\u00f3, se utiliz\u00f3 la pcr y la serolog\u00eda convencional para monitorizar la respuesta al tratamiento con benznidazol en pacientes con enfermedad de chagas aguda. En pacientes en fase cr\u00f3nica de la enfermedad, adem\u00e1s de la pcr y la serolog\u00eda convencional, tambi\u00e9n los p\u00e9ptidos recombinantes de t. Cruzi kmp11, hsp70 y pfr2 se utilizaron para evaluar la eficacia terap\u00e9utica. Tambi\u00e9n se estudio el papel del \u00f3xido n\u00edtrico en la aparici\u00f3n de efectos secundarios al tratamiento.  la pcr permiti\u00f3 una detecci\u00f3n precoz del fallo terap\u00e9utico en pacientes agudos y cr\u00f3nicos. La determinaci\u00f3n de los niveles de anticuerpos mediante serolog\u00eda convencional en pacientes agudos permiti\u00f3 evaluar la eficacia del tratamiento y establecer la curaci\u00f3n en todos los pacientes. En pacientes cr\u00f3nicos, tanto la serolog\u00eda convencional como la no convencional, mostraron un efecto beneficioso del tratamiento con benznidazol al disminuir los niveles de anticuerpos circulantes. Los niveles de \u00f3xido n\u00edtrico no parecen estar relacionados con la aparici\u00f3n de efectos adversos al tratamiento. resumen tesis doctoral mj mu\u00f1oz d\u00e1vila en ingl\u00e9s: in this study, pcr and convencional serology were used for monitoring benznidazol treatment in patients with acute chagas disease. In patients in the chronic fase, in addition to pcr and conventional serology, recombinant t. Cruzi antigens kmp11, hsp70 and pfr2 were also used to evaluate treatment efficacy. Nitric oxide concentration was studied in patients with adverse reactions to benznidazole treatment. pcr allowed detection of early therapeutic failure in acute and chronic patients. Monitoring antibody levels in patients with acute chagas disease was useful to demonstrate treatment efficacy and patients cure. In chronic patients, conventional and non-conventional serology, demonstrated beneficial effect of benznidazole in reducing antibody levels. Nitric oxide levels don&apos;t seem to be related with adverse reactions following treatment with benznidazole. listado de palabras clave:  enfermedad de chagas, monitorizaci\u00f3n respuesta tratamiento, benznidazol, pcr, serolog\u00eda y t. Cruzi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3n de la respuesta al tratamiento con benznidazol en pacientes con enfermedad de chagas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3n de la respuesta al tratamiento con benznidazol en pacientes con enfermedad de chagas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jose Mu\u00f1oz Davila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Segovia Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Alonso bedate <\/li>\n<li>m. carmen Thomas  carazo (vocal)<\/li>\n<li>Manuel Carlos L\u00f3pez l\u00f3pez (vocal)<\/li>\n<li>eduardo Berriatua fern\u00e1ndez de larrea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jose Mu\u00f1oz Davila En este estudi\u00f3, se utiliz\u00f3 la pcr y la serolog\u00eda convencional para monitorizar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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