{"id":112803,"date":"2012-12-06T00:00:00","date_gmt":"2012-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/exposicion-fetal-a-drogas-de-abuso-durante-el-primer-trimestre-de-la-gestacion\/"},"modified":"2012-12-06T00:00:00","modified_gmt":"2012-12-06T00:00:00","slug":"exposicion-fetal-a-drogas-de-abuso-durante-el-primer-trimestre-de-la-gestacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-analitica\/exposicion-fetal-a-drogas-de-abuso-durante-el-primer-trimestre-de-la-gestacion\/","title":{"rendered":"Exposici\u00f3n fetal a drogas de abuso durante el primer trimestre de la gestaci\u00f3n."},"content":{"rendered":"

Tesis doctoral de Aurora Sanchez Capel <\/strong><\/h2>\n

El objetivo de este trabajo es el estudio del paso transplacentario de sustancias de abuso durante el primer trimestre de la gestaci\u00f3n mediante el an\u00e1lisis en matrices no convencionales de las principales drogas de abuso y sus metabolitos. Hemos analizado la exposici\u00f3n intrauterina a estas sustancias utilizando cuestionarios estructurados y la presencia de biomarcadores de exposici\u00f3n en la placenta y los restos fetales procedentes de 258 mujeres que interrumpieron voluntariamente su embarazo en la semana 12 de la gestaci\u00f3n. Se hallaron 93 muestras pareadas positivas (36%), 65 en placenta y 50 en restos fetales. El 1.6% de los casos fueron positivos a cannabis, 2.7% a coca\u00edna, 25.6% a tabaco y 5.8 % casos presentaban policonsumo. Los biomarcadores estudiados evidencian la capacidad de estas sustancias de atravesar la barrera placentaria en distinta extensi\u00f3n y demuestran que existe una infradeclaraci\u00f3n del consumo de drogas de abuso entre la poblaci\u00f3n estudiada. palabras clave: sustancias de abuso placenta restos fetales paso transplacentario primer trimestre t\u00e9rminos unesco: abuso de drogas: 611303 toxicolog\u00eda: 321400 medicina forense: 320300 qu\u00edmica anal\u00edtica: 230100 abstract the aim of this study is to analyze the transplacental transfer of drug abuse substances during the first trimester of pregnancy by analyzing the mainly substances of abuse and metabolites in unconventional matrices. We have analyzed intrauterine exposure to these substances with structured questionnaires and exposure biomarkers in placenta and fetal remains from 258 women who voluntarily terminated their pregnancy at 12 weeks of gestation. 93 matched samples were found positive (36%), 65 in placenta and 50 in fetal remains. 1.6% of the cases were positive for cannabis, 2.7% for cocaine, 25.6% for tobacco and 5.8% to more than one drug. These biomarkers show the capacity of these substances to cross the placental barrier to several extent and they also confirm that participants do not self-report drug abuse reliably. keywords: abuse substances placenta fetal remains transplacental passage first trimester<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abExposici\u00f3n fetal a drogas de abuso durante el primer trimestre de la gestaci\u00f3n.<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Exposici\u00f3n fetal a drogas de abuso durante el primer trimestre de la gestaci\u00f3n. <\/li>\n
  • Autor:<\/strong>\u00a0 Aurora Sanchez Capel <\/li>\n
  • Universidad:<\/strong>\u00a0 Murcia<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2012<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Aurelio Luna Maldonado<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: lorenzo Abad Martinez <\/li>\n
        • simona Pichini (vocal)<\/li>\n
        • oriol Vall combelles (vocal)<\/li>\n
        • Mar\u00eda dolores Perez carceles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Aurora Sanchez Capel El objetivo de este trabajo es el estudio del paso transplacentario de sustancias de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7463,968,8235,18,401],"tags":[3274,224276,5494,42642,42459,158416],"class_list":["post-112803","post","type-post","status-publish","format-standard","hentry","category-abuso-de-drogas","category-medicina-forense","category-murcia","category-quimica-analitica","category-toxicologia","tag-aurelio-luna-maldonado","tag-aurora-sanchez-capel","tag-lorenzo-abad-Martinez","tag-maria-dolores-perez-carceles","tag-oriol-vall-combelles","tag-simona-pichini"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112803"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112803\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}