{"id":112816,"date":"2018-03-11T10:39:58","date_gmt":"2018-03-11T10:39:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedad-osea-en-el-trasplante-renal-marcadores-bioqua%c2%admicos-de-remodelado-oseo-y-genotipado-de-polimorfismos\/"},"modified":"2018-03-11T10:39:58","modified_gmt":"2018-03-11T10:39:58","slug":"enfermedad-osea-en-el-trasplante-renal-marcadores-bioqua%c2%admicos-de-remodelado-oseo-y-genotipado-de-polimorfismos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/enfermedad-osea-en-el-trasplante-renal-marcadores-bioqua%c2%admicos-de-remodelado-oseo-y-genotipado-de-polimorfismos\/","title":{"rendered":"Enfermedad \u00f3sea en el trasplante renal: marcadores bioqu\u00edmicos de remodelado \u00f3seo y genotipado de polimorfismos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Martinez Villanueva <\/strong><\/h2>\n<p>Palabras clave:  trasplante renal, osteoporosis, marcadores bioqu\u00edmicos de remodelado \u00f3seo, gen\u00e9tica, densidad mineral \u00f3sea  keywords:  kidney transplant, osteoporosis, biochemical markers of bone turnover, genetic, bone mineral density  enfermedad \u00f3sea en el trasplante renal: marcadores bioqu\u00edmicos de remodelado \u00f3seo y genotipado de polimorfismos  los pacientes trasplantados renales presentan una r\u00e1pida p\u00e9rdida de masa \u00f3sea y mayor riesgo de fracturas en comparaci\u00f3n con la poblaci\u00f3n general. La osteoporosis es una enfermedad multifactorial en la que el componente gen\u00e9tico puede influir hasta un 80%  se han estudiado durante dos a\u00f1os 139 pacientes trasplantados renales  para evaluar la utilidad de los marcadores bioqu\u00edmicos de remodelado \u00f3seo (mbro) frente a la densitometr\u00eda (dmo) como prueba est\u00e1ndar  y los polimorfismos de  genes del col\u00e1geno tipo 1 (col1a1-spi), receptor de calcitonina (ctr-alui), receptor de vitamina d (vdr-foki, vdr-bsmi) y receptor de estr\u00f3genos (esr-xbai, esr-pvuii) para evaluar su contribuci\u00f3n a la p\u00e9rdida de masa \u00f3sea.  se encuentra una disminuci\u00f3n  de dmo en columna lumbar y cuello femoral, mbro correlacionan con dmo,  polimorfismos de vdr-bsmi y esr1-xbai predisponen a una mayor p\u00e9rdida de masa \u00f3sea, sugiriendo su utilidad en el diagn\u00f3stico precoz de enfermedad \u00f3sea postrasplante.  bone disease in renal transplantation: biochemical markers of bone turnover and genotyping of polymorphisms renal transplant patients show a rapid loss of bone mass and increased risk of fracture compared with the general population. Osteoporosis is a multifactorial skeletal disease in which genetic component may influence up to 80% 139 kidney transplant patients have been studied for two years to evaluate the usefulness of biochemical markers of bone turnover (bmbt) versus densitometry (bmd) as  standard test and to genotype polymorphisms of type 1 collagen (col1a1-spi), calcitonin receptor (ctr-alui), vitamin d receptor (vdr-foki, vdr-bsmi) and estrogen receptor (esr-xbai, esr-pvuii), assessing their potential contribution to bone loss. a significant decrease of bmd in both lumbar spine and femoral neck was found, bmbt correlate with bmd, polymorphisms of vdrb-bsmi and esr1-xbai genes predispose to greater bone mass loss suggesting its usefulness in early diagnosis of bone disease.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedad \u00f3sea en el trasplante renal: marcadores bioqu\u00edmicos de remodelado \u00f3seo y genotipado de polimorfismos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedad \u00f3sea en el trasplante renal: marcadores bioqu\u00edmicos de remodelado \u00f3seo y genotipado de polimorfismos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Martinez Villanueva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Tovar Zapata<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  manuel Ballesta gimeno <\/li>\n<li>miren nerea Varo cenarruzabeitia (vocal)<\/li>\n<li>Francisco valeriano Avil\u00e9s plaza (vocal)<\/li>\n<li>Luisa Jimeno garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Martinez Villanueva Palabras clave: trasplante renal, osteoporosis, marcadores bioqu\u00edmicos de remodelado \u00f3seo, gen\u00e9tica, densidad mineral \u00f3sea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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