{"id":112841,"date":"2018-03-11T10:39:58","date_gmt":"2018-03-11T10:39:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-un-peptido-derivado-del-receptor-tipo-iii-del-tgf-1-sobre-la-activacion-de-la-nadph-oxidasa-en-el-rinon-de-la-rata-espontaneamente-hipertensa-consecuencias-en-la-fibrosis-renal\/"},"modified":"2018-03-11T10:39:58","modified_gmt":"2018-03-11T10:39:58","slug":"efectos-de-un-peptido-derivado-del-receptor-tipo-iii-del-tgf-1-sobre-la-activacion-de-la-nadph-oxidasa-en-el-rinon-de-la-rata-espontaneamente-hipertensa-consecuencias-en-la-fibrosis-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/efectos-de-un-peptido-derivado-del-receptor-tipo-iii-del-tgf-1-sobre-la-activacion-de-la-nadph-oxidasa-en-el-rinon-de-la-rata-espontaneamente-hipertensa-consecuencias-en-la-fibrosis-renal\/","title":{"rendered":"Efectos de un p\u00e9ptido derivado del receptor tipo iii del tgf- β1 sobre la activaci\u00f3n de la nadph oxidasa en el ri\u00f1\u00f3n de la rata espont\u00e1neamente hipertensa. consecuencias en la fibrosis renal\u00bb"},"content":{"rendered":"

Tesis doctoral de Ana Bel\u00e9n Baltan\u00e1s Bordonaba <\/strong><\/h2>\n

Nadph oxidases constitute a major source of superoxide anion in hypertension. Several studies suggest an important role of nadph oxidases in different effects mediated by tgf-β1. We investigated whether a chronic treatment with p144, a peptide synthesized from type iii tgf- β1 receptor, inhibited nadph oxidases in the renal cortex of spontaneously hypertensive rats (shr). We show that chronic administration of p144 significantly reduced the nadph oxidase expression and activity as well as the nitrotyrosine levels observed in control shr rats. In addition, p144 was also able to reduce the significant increases in the renal fibrosis and in mrna expression of different components of collagen metabolism, as well as in the levels of connective tissue growth factor (ctgf) observed in shr rats. Finally, tgf-β1 stimulated nrk52e exhibited significant increases in nadph oxidase expression and activity as well as tgf-β1-dependent intracellular pathway that were inhibited in the presence of p144. for the first time, we show that p144 modulates intracellular reactive oxygen species homeostasis and regulates activation of nadph oxidases, and the subsequent renal fibrosis, by using an in vivo and in vitro system with established cell line, providing a novel therapeutic tool. We demonstrate that p144 inhibits nadph oxidases and prevents oxidative stress in kidneys from hypertensive rats. Our data also allow us to suggest that these effects may be underlying in the renal antifibrotic effect of p144.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEfectos de un p\u00e9ptido derivado del receptor tipo iii del tgf- β1 sobre la activaci\u00f3n de la nadph oxidasa en el ri\u00f1\u00f3n de la rata espont\u00e1neamente hipertensa. consecuencias en la fibrosis renal\u00bb<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de un p\u00e9ptido derivado del receptor tipo iii del tgf- β1 sobre la activaci\u00f3n de la nadph oxidasa en el ri\u00f1\u00f3n de la rata espont\u00e1neamente hipertensa. consecuencias en la fibrosis renal\u00bb <\/li>\n
  • Autor:<\/strong>\u00a0 Ana Bel\u00e9n Baltan\u00e1s Bordonaba <\/li>\n
  • Universidad:<\/strong>\u00a0 Navarra<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2012<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Ana Fortu\u00f1o Gil<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: carmen Mar\u00eda Vazquez cueto <\/li>\n
        • Javier G\u00f3mez ambrosi (vocal)<\/li>\n
        • david Sanz rosa (vocal)<\/li>\n
        • Ana Mar\u00eda Briones alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Ana Bel\u00e9n Baltan\u00e1s Bordonaba Nadph oxidases constitute a major source of superoxide anion in hypertension. Several studies […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,17749],"tags":[224340,55915,178015,1268,165573,137973],"class_list":["post-112841","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-navarra","tag-ana-belen-baltanas-bordonaba","tag-ana-fortuno-gil","tag-ana-maria-briones-alonso","tag-carmen-maria-vazquez-cueto","tag-david-sanz-rosa","tag-javier-gomez-ambrosi"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112841"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112841\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}