{"id":11285,"date":"2018-03-09T08:56:32","date_gmt":"2018-03-09T08:56:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-cepas-de-helicobacter-pylori-reproduccion-del-modelo-animal-en-ratones-y-estudio-de-los-mecanismos-de-la-inflamacion\/"},"modified":"2018-03-09T08:56:32","modified_gmt":"2018-03-09T08:56:32","slug":"caracterizacion-molecular-de-cepas-de-helicobacter-pylori-reproduccion-del-modelo-animal-en-ratones-y-estudio-de-los-mecanismos-de-la-inflamacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-molecular-de-cepas-de-helicobacter-pylori-reproduccion-del-modelo-animal-en-ratones-y-estudio-de-los-mecanismos-de-la-inflamacion\/","title":{"rendered":"Caracterizaci\u00f3n molecular de cepas de \u00abhelicobacter pylori\u00bb. reproducci\u00f3n del modelo animal en ratones y estudio de los mecanismos de la inflamaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julian Gomez Martinez <\/strong><\/h2>\n<p>Fundamento  a ra\u00edz del descubrimiento de helicobacter pylori, hemos asistido a una revoluci\u00f3n en la pr\u00e1ctica de la medicina. Las consecuencias de esta infecci\u00f3n son enfermedades como \u00falcera p\u00e9ptica, gastritis cr\u00f3nica, adenocarcinoma g\u00e1strico y linfoma tipo malt. El car\u00e1cter cr\u00f3nico as\u00ed como la elevada incidencia de la infecci\u00f3n, ha despertado en los \u00faltimos a\u00f1os un gran inter\u00e9s cient\u00edfico.  objetivos  1,- estudiar la influencia del m\u00e9todo utilizado enla esterilizaci\u00f3n de las pinzas de biopsia endosc\u00f3pica en el rendimiento del cultivo de h.Pylori.  2,- caracterizar molecularmente las cepas de h.Pylori aisladas de muestras cl\u00ednicas para los genes vaca y subtipos, caga y estudiar su asociaci\u00f3n con el efecto citot\u00f3xico.  3,- reproducir el modelo animal de infecci\u00f3n por h.Pylori en ratones.  4,- estudiar mediante microscop\u00eda intravital, los mecanismos de la inflamaci\u00f3n en la infecci\u00f3n cr\u00f3nica en el modelo experimental.  resultados  la sensibilidad del cultivo es independiente de la t\u00e9cnica de esterilizaci\u00f3n utilizada para las pinzas de biopsia. Existe gran diversidad entre el genotipo de las cepas aisladas en nuestro entorno. Todas las cepas presentan el gen vaca +, del subptio s1\/m1 y corresponden a enfermos con \u00falcera p\u00e9ptida. el modelo animal reproduce la patolog\u00eda gastroduodenal observada en el hombre. La infecci\u00f3n induce la aparici\u00f3n del fen\u00f3meno de rodamiento leucocitario (\u00abrolling\u00bb) y la formaci\u00f3n de agregados leucocito-plaquetarios en la microcirculaci\u00f3n g\u00e1strica del modelo experimental. Pacientes con infecci\u00f3n por h.Pylori tambi\u00e9n muestran el fen\u00f3meno de agregaci\u00f3n plaquetar, lo que constituye un nexo de uni\u00f3n entre la fisiopatolog\u00eda de la infecci\u00f3n y la cardiopat\u00eda isqu\u00e9mica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n molecular de cepas de \u00abhelicobacter pylori\u00bb. reproducci\u00f3n del modelo animal en ratones y estudio de los mecanismos de la inflamaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n molecular de cepas de \u00abhelicobacter pylori\u00bb. reproducci\u00f3n del modelo animal en ratones y estudio de los mecanismos de la inflamaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julian Gomez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Teresa Jimenez De Anta Losada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Congregado c\u00f3rdoba <\/li>\n<li>Jos\u00e9 Mar\u00eda Sanchez tapias (vocal)<\/li>\n<li> Batolome comas rosa Mar\u00eda (vocal)<\/li>\n<li> Horcajada gallego Juan  pablo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julian Gomez Martinez Fundamento a ra\u00edz del descubrimiento de helicobacter pylori, hemos asistido a una revoluci\u00f3n en 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