{"id":112918,"date":"2018-03-11T10:40:08","date_gmt":"2018-03-11T10:40:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/new-genetic-markes-for-treatment-personalization-in-pediatric-acute-lymphoblastic-leukemia\/"},"modified":"2018-03-11T10:40:08","modified_gmt":"2018-03-11T10:40:08","slug":"new-genetic-markes-for-treatment-personalization-in-pediatric-acute-lymphoblastic-leukemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-humana\/new-genetic-markes-for-treatment-personalization-in-pediatric-acute-lymphoblastic-leukemia\/","title":{"rendered":"New genetic markes for treatment personalization in pediatric acute lymphoblastic leukemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elixabet Lopez Lopez <\/strong><\/h2>\n<p>La leucemia linfobl\u00e1stica aguda (lla) es el c\u00e1ncer pedi\u00e1trico m\u00e1s com\u00fan. Es un desorden de las c\u00e9lulas linfobl\u00e1sticas, que son las precursoras de las c\u00e9lulas linf\u00e1ticas, y se caracteriza por la acumulaci\u00f3n en m\u00e9dula \u00f3sea y sangre de peque\u00f1as c\u00e9lulas bl\u00e1sticas con poco citoplasma y cromatina dispersa. En las \u00faltimas d\u00e9cadas, se ha conseguido aumentar la supervivencia del 10% al 80% pero todav\u00eda hay un 20% de pacientes que no responden al tratamiento. Esta mejor\u00eda se ha conseguido mediante la implantaci\u00f3n de terapias combinadas y la adecuaci\u00f3n de la terapia a grupos de riesgo. Los pacientes se separan en tres grupos de riesgo, riesgo est\u00e1ndar (re), alto riesgo (ar) y muy alto riesgo (mar), en base a marcadores pron\u00f3sticos, entre los que se incluyen alteraciones citogen\u00e9ticas. Sin embargo, a lo largo del tratamiento, nos encontramos con dos problemas:1) por un lado, algunos de los pacientes incluidos en el grupo de re y ar no responden bien al tratamiento y pasan ar y mar respectivamente. Esto quiere decir que los grupos de riesgo no est\u00e1n bien definidos. Por lo tanto, ser\u00eda de inter\u00e9s poder caracterizar los pacientes que realmente son re y ar y aqu\u00e9llos que desde un principio deber\u00edan haber sido considerados como de mayor riesgo.2) por otro lado, un alto porcentaje de pacientes experimenta toxicidad, que puede llegar a ser muy grave en algunos casos, siendo necesario parar el tratamiento. Por este motivo, ser\u00eda altamente beneficioso poder reconocer a los pacientes que van a ser m\u00e1s sensibles al tratamiento para, de ese modo, poder ajustar la dosis.Por todo esto, creemos que una mejor asignaci\u00f3n de los pacientes de lla a grupos de riesgo y la personalizaci\u00f3n de la dosis, mediante nuevos marcadores gen\u00e9ticos, permitir\u00eda mejorar la respuesta al tratamiento.En este estudio nos planteamos, por lo tanto, dos objetivos: 1) llevar a cabo la identificaci\u00f3n de nuevas alteraciones gen\u00e9ticas presentes en el tumor para una mejor caracterizaci\u00f3n del riesgo y 2) realizar una caracterizaci\u00f3n gen\u00e9tica del individuo que permita predecir la respuesta al tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>New genetic markes for treatment personalization in pediatric acute lymphoblastic leukemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 New genetic markes for treatment personalization in pediatric acute lymphoblastic leukemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elixabet Lopez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Africa Garcia Orad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier \u00e1lvarez guisasola <\/li>\n<li>Juan  Fernando Garcia garcia (vocal)<\/li>\n<li>marry Van den heuvel eibrink (vocal)<\/li>\n<li>bego\u00f1a Ochoa olascoaga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elixabet Lopez Lopez La leucemia linfobl\u00e1stica aguda (lla) es el c\u00e1ncer pedi\u00e1trico m\u00e1s com\u00fan. Es un desorden [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[11771,2820,12909],"tags":[200330,28413,224453,142031,65722,224454],"class_list":["post-112918","post","type-post","status-publish","format-standard","hentry","category-genetica-clinica","category-genetica-humana","category-pais-vasco-euskal-herriko-unibertsitatea","tag-africa-garcia-orad","tag-begona-ochoa-olascoaga","tag-elixabet-lopez-lopez","tag-francisco-javier-alvarez-guisasola","tag-juan-fernando-garcia-garcia","tag-marry-van-den-heuvel-eibrink"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=112918"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/112918\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=112918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=112918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=112918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}