{"id":112965,"date":"2012-06-07T00:00:00","date_gmt":"2012-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-acido-folico-dietetico-en-el-desarrollo-del-paladar-de-raton\/"},"modified":"2012-06-07T00:00:00","modified_gmt":"2012-06-07T00:00:00","slug":"papel-del-acido-folico-dietetico-en-el-desarrollo-del-paladar-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-del-acido-folico-dietetico-en-el-desarrollo-del-paladar-de-raton\/","title":{"rendered":"Papel del \u00e1cido f\u00f3lico diet\u00e9tico en el desarrollo del paladar de rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estela Maldonado Bautista <\/strong><\/h2>\n<p>Tesis doctoral (2012) presentada por: estela maldonado bautista t\u00edtulo: papel del \u00e1cido f\u00f3lico diet\u00e9tico en el desarrollo del paladar de rat\u00f3n un correcto desarrollo del paladar implica una actuaci\u00f3n concreta de los mecanismos b\u00e1sicos causantes de la  palatog\u00e9nesis y sus alteraciones pueden desencadenar fisura palatina (fp). Existen genes estrechamente relacionados con la palatog\u00e9nesis, como tgf-?3, cuyo bloqueo en ratones ocasiona fp, y factores ambientales, como el d\u00e9ficit de \u00e1cido f\u00f3lico (af),  que se asocian a la aparici\u00f3n de fisuras cuando coexisten otros factores de riesgo.  en este trabajo se plantean dos objetivos: el primero es analizar si la carencia de af en la dieta de hembras de rat\u00f3n c57 silvestres puede provocar alteraciones en  los mecanismos b\u00e1sicos requeridos en la palatog\u00e9nesis de su progenie y qu\u00e9 relaci\u00f3n puede tener ello con la acci\u00f3n de tgf-?3. El segundo, es determinar si la administraci\u00f3n de una dieta con un suplemento de af veinte veces superior a los niveles fis iol\u00f3gicos a hembras de rat\u00f3n c57 heterocigotas para tgf-?3 reduce la aparici\u00f3n de la fp que presentan sus descendientes homocigotos negativos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del \u00e1cido f\u00f3lico diet\u00e9tico en el desarrollo del paladar de rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del \u00e1cido f\u00f3lico diet\u00e9tico en el desarrollo del paladar de rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estela Maldonado Bautista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Concepci\u00f3n Mart\u00ednez \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin gregorio Zapata gonzalez <\/li>\n<li>beatriz Berenguer fr\u00ed\u00b6hner (vocal)<\/li>\n<li>Elena Alonso aperte (vocal)<\/li>\n<li>natalia \u00fabeda mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estela Maldonado Bautista Tesis doctoral (2012) presentada por: estela maldonado bautista t\u00edtulo: papel del \u00e1cido f\u00f3lico diet\u00e9tico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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