{"id":112978,"date":"2012-09-07T00:00:00","date_gmt":"2012-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategia-multimarcador-en-la-estratificacion-del-riesgo-del-sa%c2%adndrome-coronario-agudo-y-troponina-negativa\/"},"modified":"2012-09-07T00:00:00","modified_gmt":"2012-09-07T00:00:00","slug":"estrategia-multimarcador-en-la-estratificacion-del-riesgo-del-sa%c2%adndrome-coronario-agudo-y-troponina-negativa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estrategia-multimarcador-en-la-estratificacion-del-riesgo-del-sa%c2%adndrome-coronario-agudo-y-troponina-negativa\/","title":{"rendered":"Estrategia multimarcador en la estratificaci\u00f3n del riesgo del s\u00edndrome coronario agudo y troponina negativa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Mar\u00eda Garcia Salas <\/strong><\/h2>\n<p>La evaluaci\u00f3n del pron\u00f3stico y estratificaci\u00f3n del riesgo en el s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st (scasest) con troponina negativa, sigue siendo un desaf\u00edo. Los principales hallazgos de esta tesis fueron: i) s\u00f3lo il-6 y pcrus presentan concentraciones aumentadas en pacientes de bajo-moderado riesgo con scasest y troponina t est\u00e1ndar negativa con respecto a pacientes con cardiopat\u00eda isqu\u00e9mica estable y a sujetos sanos; ii) los niveles de il6, pcrus y pigf se asociaron independientemente con eventos adversos a los 6 meses de seguimiento; iii) una estrategia multimarcador, definida como 2 \u00f3 3 biomarcadores elevados con papel pron\u00f3stico, mostr\u00f3 ser el mayor predictor independiente de eventos adversos en estos pacientes; iv) la adici\u00f3n de esta estrategia multimarcador a la escala timi, mejor\u00f3 la estimaci\u00f3n del riesgo de los pacientes de bajo-moderado riesgo con scasest y troponina t est\u00e1ndar negativa, y reclasific\u00f3 correctamente un tercio de estos pacientes. palabras clave:  scasest, troponina negativa, biomarcadores, pron\u00f3stico. abstract: we sought to explore the prognostic value of biomarkers among low-moderate risk patients with nste-acs and troponin t negative, and to evaluate whether a multimarker strategy could improve the predictive performance of timi risk score. The main findings were: i) only the il-6 and hscrp showed higher levels in these patients respect to patients with stable ischemic heart disease and healthy subjects; ii) the levels of il-6, hscrp and pigf were independently associated with adverse events at 6 months follow-up; iii) a multimarker strategy, defined as 2 or 3 elevated biomarkers with a prognostic role, proved to be the greater independent predictor of adverse events in low-moderate risk patients with nste-acs and troponin t negative; iv) the addition of this multimarker strategy to timi risk score improved the estimation of risk in low-moderate risk patients with nste-acs and troponin t negative, and correctly reclassify one third of these patients. keywords: nste-acs, troponin t negative, biomarker, prognosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategia multimarcador en la estratificaci\u00f3n del riesgo del s\u00edndrome coronario agudo y troponina negativa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategia multimarcador en la estratificaci\u00f3n del riesgo del s\u00edndrome coronario agudo y troponina negativa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Mar\u00eda Garcia Salas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Mar\u00edn Ortu\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raimundo Goberna ortiz <\/li>\n<li>vicente Bodi peris (vocal)<\/li>\n<li>isabel Tovar zapata (vocal)<\/li>\n<li>jordi Ordo\u00f1ez llanos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Mar\u00eda Garcia Salas La evaluaci\u00f3n del pron\u00f3stico y estratificaci\u00f3n del riesgo en el s\u00edndrome coronario agudo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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