{"id":113105,"date":"2018-03-11T10:40:24","date_gmt":"2018-03-11T10:40:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/angiogenic-molecular-signature-in-colorectal-cancer-pharmacogenomic-implications-for-the-use-of-anti-angiogenic-therapies\/"},"modified":"2018-03-11T10:40:24","modified_gmt":"2018-03-11T10:40:24","slug":"angiogenic-molecular-signature-in-colorectal-cancer-pharmacogenomic-implications-for-the-use-of-anti-angiogenic-therapies","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/angiogenic-molecular-signature-in-colorectal-cancer-pharmacogenomic-implications-for-the-use-of-anti-angiogenic-therapies\/","title":{"rendered":"Angiogenic molecular signature in colorectal cancer: pharmacogenomic implications for the use of anti-angiogenic therapies"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda Abajo Guijarro <\/strong><\/h2>\n<p>In the framework of personalized medicine in antiangiogenesis, we took a translational research approach to explore the angiogenic molecular signature of advanced crc patients.  as derived from our findings in vitro, the tumour microenvironment of crc metastases would be different to that of primary tumours. The mcrc more aggressive molecular phenotype provides some intrinsic resistance to the hypoxic induction of vegf expression. The distinct metastatic \u00c2\u00bfsecretome\u00c2\u00bf emerge as potential prognostic markers and alternative intervention targets. the identification of predictive biomarkers for response to bevacizumab-based combination therapy allows a more informed therapeutic decision for patients with mcrc. Platelet-normalized serum circulating vegf baseline levels are significantly lower in vegf-2578aa and vegf-460cc carriers; and low-vegf levels-associated snps correlate with a better clinical outcome of ttp. A predictive risk score is calculated considering the k\u00ed\u00b6hne low-risk category, dcr achievement and any favourable vegf genotype, which renders four different risk groups. high serum levels of egf and mdc and low levels of il-10, il-6 and il-8 are associated with a higher likelihood of response to the bevacizumab-based combination therapy. A risk signature is calculated by summing-up the number of high-risk factors (below and above the median for egf and mdc, and il-10, il-6 and il-8, respectively) significantly correlates with progression and survival outcomes, improving single factor\u00c2\u00bfs predictive ability. Exposure to the combination therapy reduces levels of il-8 and increases levels of the protective mdc, findings which are in agreement with the reported roles for both cytokines inflammatory and angiogenesis mediators in colorectal cancer.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Angiogenic molecular signature in colorectal cancer: pharmacogenomic implications for the use of anti-angiogenic therapies<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Angiogenic molecular signature in colorectal cancer: pharmacogenomic implications for the use of anti-angiogenic therapies <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda Abajo Guijarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Garcia Foncillas Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Vidal vanaclocha <\/li>\n<li>andreas Voss (vocal)<\/li>\n<li>ignacio Jos\u00e9 Encio Martinez (vocal)<\/li>\n<li>Mar\u00eda no Monzo planella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda Abajo Guijarro In the framework of personalized medicine in antiangiogenesis, we took a translational research [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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