{"id":113130,"date":"2012-03-09T00:00:00","date_gmt":"2012-03-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-diversas-variantes-geneticas-y-el-estilo-de-vida-sobre-el-riesgo-de-obesidad-en-poblacion-mayor-de-55-anos-de-la-cohorte-sun\/"},"modified":"2012-03-09T00:00:00","modified_gmt":"2012-03-09T00:00:00","slug":"influencia-de-diversas-variantes-geneticas-y-el-estilo-de-vida-sobre-el-riesgo-de-obesidad-en-poblacion-mayor-de-55-anos-de-la-cohorte-sun","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/influencia-de-diversas-variantes-geneticas-y-el-estilo-de-vida-sobre-el-riesgo-de-obesidad-en-poblacion-mayor-de-55-anos-de-la-cohorte-sun\/","title":{"rendered":"Influencia de diversas variantes gen\u00e9ticas y el estilo de vida sobre el riesgo de obesidad en poblaci\u00f3n mayor de 55 a\u00f1os de la cohorte sun"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cecilia Galbete Ci\u00e1urriz <\/strong><\/h2>\n<p>?Influence of diverse gene variants and lifestyle factors on obesity risk in subjects over 55 years of the sun project\u00c2\u00bf genetic and lifestyle factors, such as dietary patterns and physical activity (pa) levels, may interact modifying obesity risk. The aim of this work was to explore the influence of diverse gene variants (rs1801282 of pparg2 gene, rs9939609 of fto gene and rs1801260 snp of clock gene) on obesity risk, and to examine their potential interaction with lifestyle factors in an elderly population of the sun project. Subjects (n=986, aged 69\u00c2\u00b16 years old) were recruited from the sun (\u00c2\u00bfseguimiento universidad de navarra\u00c2\u00bf) project. Dna was obtained from saliva while lifestyle and dietary data were collected by validated self-report questionnaires. Genotype was assessed by rt-pcr plus allele discrimination. For the pro12ala gene variant of the pparg2 (rs1801282) the ala12 allele was associated with an increased obesity risk a significant interaction between this snp and carbohydrate (cho) intake for obesity risk was observed and within subjects with a high cho intake those carrying the 12ala allele had higher obesity risk than pro12pro subjects. Moreover, a meta-analysis encompassing 49.092 subjects showed higher levels of bmi in those subjects carrying the ala12 allele. This effect was more relevant in the caucasian men subgroup. It also was observed that the co-presence of the ala12 allele and the a risk allele of the rs9939609 snp of the fto gene increased bmi levels even if no association was observed between this fto gene variant and obesity status. Additionally, this effect was significantly enhanced in subjects with a high cho intake and low pa levels. Finally, interaction between the 3111t\/c snp of clock gene (rs1801260) and sex for overweight\/obesity risk was observed. Women carrying the c allele of clock gene had a lower risk of overweight\/obesity compared to non carriers. This association was enhanced in those women with a high pa level. Furthermore, a significant interaction between the 3111t\/c gene variant and pa for overweight\/obesity risk was observed but only in women.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de diversas variantes gen\u00e9ticas y el estilo de vida sobre el riesgo de obesidad en poblaci\u00f3n mayor de 55 a\u00f1os de la cohorte sun<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de diversas variantes gen\u00e9ticas y el estilo de vida sobre el riesgo de obesidad en poblaci\u00f3n mayor de 55 a\u00f1os de la cohorte sun <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cecilia Galbete Ci\u00e1urriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/09\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amelia Angela Marti Del Moral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 alfredo Martinez hernandez <\/li>\n<li>Francisco Perez jimenez (vocal)<\/li>\n<li>pilar Guallar castillon (vocal)<\/li>\n<li>Miguel \u00e1ngel Mart\u00ednez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cecilia Galbete Ci\u00e1urriz ?Influence of diverse gene variants and lifestyle factors on obesity risk in subjects over [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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