{"id":113142,"date":"2012-07-09T00:00:00","date_gmt":"2012-07-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-nuevos-procesos-multicomponente-a-la-sa%c2%adntesis-de-derivados-de-quinolina\/"},"modified":"2012-07-09T00:00:00","modified_gmt":"2012-07-09T00:00:00","slug":"aplicacion-de-nuevos-procesos-multicomponente-a-la-sa%c2%adntesis-de-derivados-de-quinolina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aplicacion-de-nuevos-procesos-multicomponente-a-la-sa%c2%adntesis-de-derivados-de-quinolina\/","title":{"rendered":"Aplicaci\u00f3n de nuevos procesos multicomponente a la s\u00edntesis de derivados de quinolina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pascual Ribelles Torres <\/strong><\/h2>\n<p>En esta tesis doctoral se han desarrollado las siguientes transformaciones sint\u00e9ticas: 1. La reacci\u00f3n multicomponente catalizada por can (nitrato c\u00e9rico am\u00f3nico) entre aldeh\u00eddos arom\u00e1ticos, metilvinil\u00e9ter y anilinas sustituidas en meta, origina deriv ados de trans-4-anilino-2-aril-1,2,3,4-tetrahidroquinolinas en vez del producto esperado de una reacci\u00f3n de povarov. Su oxidaci\u00f3n conduce a derivados de quinolina polisustituidos. El empleo de dimetilhidrazonas como dien\u00f3filo, conduce de forma diaste reoselectiva a derivados de 2-aril-4-dimetilhidrazono-1,2,3,4-tetrahidroquinolina.  2. En los compuestos anteriores, el sustituyente dimetilhidrazono se ha transformado en un grupo vinilo diversamente sustituido. El calentamiento de las tetrahidroqui nolinas 4,4-disustituidas as\u00ed obtenidas conduce a derivados de quinolina a trav\u00e9s de una transposici\u00f3n c4-c3 del sustituyente olef\u00ednico.  3. Adem\u00e1s, la reacci\u00f3n entre los sustituyentes en 2 y 4 de las 2-acil-4-hidrazono-1,2,3,4-tetrahidroquinolinas h a conducido de forma diastereoselectiva a la obtenci\u00f3n de derivados de 2,6-metanobenzo[e][1,4]diazocina. 4. Se ha desarrollado una reacci\u00f3n de nitro-mannich intramolecular para la s\u00edntesis diastereoselectiva de tetrahidroquinolinas sustituidas en 2 y  3. 5. Tambi\u00e9n se ha comprobado que el nitrato c\u00e9rico am\u00f3nico puede actuar como catalizador para la reacci\u00f3n de friedl\u00ed\u00a4nder-borsche, y se ha aplicado a la s\u00edntesis de luotoninas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de nuevos procesos multicomponente a la s\u00edntesis de derivados de quinolina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de nuevos procesos multicomponente a la s\u00edntesis de derivados de quinolina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pascual Ribelles Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/09\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Menendez Ramos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Elena de la Cuesta el\u00f3segui <\/li>\n<li>james c. Anderson (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Quintela l\u00f3pez (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gonz\u00e1lez d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pascual Ribelles Torres En esta tesis doctoral se han desarrollado las siguientes transformaciones sint\u00e9ticas: 1. La reacci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[986,17],"tags":[221483,224810,39606,141720,2842,224809],"class_list":["post-113142","post","type-post","status-publish","format-standard","hentry","category-complutense-de-madrid","category-quimica","tag-elena-de-la-cuesta-elosegui","tag-james-c-anderson","tag-jose-carlos-menendez-ramos","tag-jose-manuel-gonzalez-diaz","tag-jose-maria-quintela-lopez","tag-pascual-ribelles-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=113142"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113142\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=113142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=113142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=113142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}