{"id":113275,"date":"2012-05-10T00:00:00","date_gmt":"2012-05-10T00:00:00","guid":{"rendered":""},"modified":"2012-05-10T00:00:00","modified_gmt":"2012-05-10T00:00:00","slug":"efecto-citoprotector-del-tacrolimus-en-un-modelo-de-sepsis-de-origen-peritoneal-modulacion-de-la-expresion-pancreatica-y-hepatica-de-las-isoformas-de-oxido-na%c2%adtrico-sintasa-y-hemooxigenasa-y-pro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-citoprotector-del-tacrolimus-en-un-modelo-de-sepsis-de-origen-peritoneal-modulacion-de-la-expresion-pancreatica-y-hepatica-de-las-isoformas-de-oxido-na%c2%adtrico-sintasa-y-hemooxigenasa-y-pro\/","title":{"rendered":"Efecto citoprotector del tacrolimus en un modelo de sepsis de origen peritoneal. modulaci\u00f3n de la expresi\u00f3n pancre\u00e1tica y hep\u00e1tica de las isoformas de \u00f3xido n\u00edtrico sintasa y hemooxigenasa y producci\u00f3n de citocinas proinflamatorias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Fernandez De Sevilla Gomez <\/strong><\/h2>\n<p>El tacr\u00f3limus (fk-506) es un inmunosupresor cuyo mecanismo de acci\u00f3n est\u00e1 relacionado con la inhibici\u00f3n de c\u00e9lulas t. Tiene cierto efecto citoprotector, disminuyendo la respuesta inflamatoria inespec\u00edfica (r.I.I), provocando disminuci\u00f3n de mediadores  inflamatorios innatos, de estr\u00e9s oxidativo y fen\u00f3menos apopt\u00f3ticos.  se han estudiado homogeneizados de h\u00edgado y p\u00e1ncreas murinos, estimulados con lipopolisac\u00e1rido bacteriano (lps), con una importante activaci\u00f3n de c\u00e9lulas inflamatoriass. Tras la es timulaci\u00f3n con lps, se midieron los niveles tisulares de tnf-? E il-1. Se ha querido estudiar el efecto del lps sobre la producci\u00f3n de estr\u00e9s oxidativo, midiendo los niveles de las isoformas de la \u00f3xido n\u00edtrico sintasa (nos) y de la hemooxigenasa (ho ), as\u00ed como las concentraciones plasm\u00e1ticas de no y co. los grupos anteriores se han comparado con homogeneizados hep\u00e1ticos y pancre\u00e1ticos estimulados con lps bacteriano tratados con dosis bajas de fk-506 (0.07 mg\/kg, 0.15 mg\/kg y 0.3 mg\/kg) midiendo  los niveles tisulares de tnf-? E il-1, nos y ho. se ha utilizado la t\u00e9cnica de western blotting. Se han considerado resultados significativos a partir de un nivel de confianza del 95 . El programa utilizado ha sido el satgraphics 5.1. se ha hallado sobreexpresi\u00f3n de los mediadores de inflamaci\u00f3n y de las isoformas de nos y ho al estimular los tejidos con lps, encontr\u00e1ndose una respuesta m\u00e1s uniforme en h\u00edgado. se observa que, en t\u00e9rminos generales, el fk-506 disminuye ciertos fen\u00f3menos asociado s a la estimulaci\u00f3n con lps, hall\u00e1ndose una respuesta m\u00e1s err\u00e1tica en tejido pancre\u00e1tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto citoprotector del tacrolimus en un modelo de sepsis de origen peritoneal. modulaci\u00f3n de la expresi\u00f3n pancre\u00e1tica y hep\u00e1tica de las isoformas de \u00f3xido n\u00edtrico sintasa y hemooxigenasa y producci\u00f3n de citocinas proinflamatorias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto citoprotector del tacrolimus en un modelo de sepsis de origen peritoneal. modulaci\u00f3n de la expresi\u00f3n pancre\u00e1tica y hep\u00e1tica de las isoformas de \u00f3xido n\u00edtrico sintasa y hemooxigenasa y producci\u00f3n de citocinas proinflamatorias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Fernandez De Sevilla Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 M. Balibrea Del Castillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias p\u00e9rez <\/li>\n<li>Manuel Armengol carrasco (vocal)<\/li>\n<li>Francisco Lozano sanchez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez montes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Fernandez De Sevilla Gomez El tacr\u00f3limus (fk-506) es un inmunosupresor cuyo mecanismo de acci\u00f3n est\u00e1 relacionado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,986],"tags":[225028,9873,22643,3775,171531,13950],"class_list":["post-113275","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-complutense-de-madrid","tag-elena-fernandez-de-sevilla-gomez","tag-francisco-lozano-sanchez","tag-jaime-arias-perez","tag-jose-antonio-rodriguez-montes","tag-jose-m-balibrea-del-castillo","tag-manuel-armengol-carrasco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=113275"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113275\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=113275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=113275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=113275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}