{"id":113329,"date":"2018-03-11T10:40:46","date_gmt":"2018-03-11T10:40:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-proceso-de-muerte-celular-inducido-por-los-derivados-bisacilimidoselenocarbamato\/"},"modified":"2018-03-11T10:40:46","modified_gmt":"2018-03-11T10:40:46","slug":"caracterizacion-del-proceso-de-muerte-celular-inducido-por-los-derivados-bisacilimidoselenocarbamato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/caracterizacion-del-proceso-de-muerte-celular-inducido-por-los-derivados-bisacilimidoselenocarbamato\/","title":{"rendered":"Caracterizaci\u00f3n del proceso de muerte celular inducido por los derivados  bisacilimidoselenocarbamato"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Iranzu Lamberto P\u00e9rez <\/strong><\/h2>\n<p>Characterization of the cell death process induced by bisacylimidoselenocarbamate derivatives  bisacylimidoselenocarbamate derivatives (bsc) are potent anticancer agents with a strong cytotoxic activity against different types of tumour cells. Based in phosphatidylserine exposure on the cell membranes we show that bsc treatment resulted in enhanced cell death in leukaemia ccrf-cem cells. Dna fragmentation detection in breast adenocarcinoma mcf-7 cells showed that bsc triggered cell death is concentration and time dependent. We also show that two of these compounds, bsc 3g and 3n, cause cell-cycle arrest in the late g2\/m in mcf-7 cells. Consistent with this, a reduction in cdk1 and cdk2 expression with no change in cyclin a and b1 was observed in this cell line. Activation of caspase-2 was also detected. However, the involvement of the caspase-dependent pathway in the process of cell death induced by either bsc 3g or 3n is discarded since cell death could not be prevented by pretreatment with the pancaspase inhibitor z-vad-fmk. Moreover, since reduced levels of p21cip and chk2 proteins but no change in p53 levels could be detected in mcf-7 cells after bsc 3g or 3n treatment our results suggest that bsc treated cells die from lethal mitosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del proceso de muerte celular inducido por los derivados  bisacilimidoselenocarbamato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del proceso de muerte celular inducido por los derivados  bisacilimidoselenocarbamato <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Iranzu Lamberto P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Palop Cubillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Luisa Campo guinea <\/li>\n<li>almudena Porras gallo (vocal)<\/li>\n<li>v\u00edctor Mart\u00ednez merino (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez zabalza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Iranzu Lamberto P\u00e9rez Characterization of the cell death process induced by bisacylimidoselenocarbamate derivatives bisacylimidoselenocarbamate derivatives (bsc) are [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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