{"id":113332,"date":"2018-03-11T10:40:46","date_gmt":"2018-03-11T10:40:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-propanolol-sobre-deterioro-cognitivo-y-las-patologa%c2%adas-amiloide-y-tau-en-distintos-modelos-experimentales-de-enfermedad-de-alzheimer\/"},"modified":"2018-03-11T10:40:46","modified_gmt":"2018-03-11T10:40:46","slug":"efectos-del-propanolol-sobre-deterioro-cognitivo-y-las-patologa%c2%adas-amiloide-y-tau-en-distintos-modelos-experimentales-de-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/efectos-del-propanolol-sobre-deterioro-cognitivo-y-las-patologa%c2%adas-amiloide-y-tau-en-distintos-modelos-experimentales-de-enfermedad-de-alzheimer\/","title":{"rendered":"Efectos del propanolol sobre deterioro cognitivo y las patolog\u00edas amiloide y tau en distintos modelos experimentales de enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Dobarro Bugar\u00edn <\/strong><\/h2>\n<p>Alzheimer\u00c2\u00bfs disease (ad) is the most common neurodegenerative disorder. Ad is defined by progressive memory loss and cognitive impairments and at the molecular level by the presence of neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, and a\u00ed\u00a2-containing amyloid plaques. antihypertensive treatments have been associated with lower incidence of clinically diagnosed ad and better cognitive function, and it has been tested whether some antihypertensive drugs might influence ad through mechanisms independent of blood pressure-lowering activity. Propranolol, a \u00ed\u00a2-adrenergic antagonist that is commonly used in the treatment of hypertension, shown experimentally to reverse cognitive deficits associated to stress and decrease of a\u00ed\u00a2 levels in vitro. in this work, we study the effect of propranolol in three animal models representing the three main groups of risk factors associated with the development of ad (age, genetics and environmental factors). After chronic treatment with propranolol at a lower dose than that used as antihypertensive (5 mg\/kg), we evaluated the cognitive status of animals and different markers of ad in the hippocampus. in all cases, propranolol was able to reverse the increased levels of a\u00ed\u00a2 and hyperphosphorylated tau. These effects may contribute to cognitive enhancement found in the three experimental models. In conclusion, propranolol seems to exert a protective role against disease neuropathology, making it a potential candidate for the treatment of ad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del propanolol sobre deterioro cognitivo y las patolog\u00edas amiloide y tau en distintos modelos experimentales de enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del propanolol sobre deterioro cognitivo y las patolog\u00edas amiloide y tau en distintos modelos experimentales de enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Dobarro Bugar\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Javier Ramirez Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Mart\u00ednez ram\u00edrez <\/li>\n<li>julen Oyarzabal santamarina (vocal)<\/li>\n<li>m\u00f3nica Garc\u00eda alloza (vocal)<\/li>\n<li>\u00e1ngel Cedazo minguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Dobarro Bugar\u00edn Alzheimer\u00c2\u00bfs disease (ad) is the most common neurodegenerative disorder. Ad is defined by progressive [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2445,17749],"tags":[83215,195489,104476,18274,225116,59186],"class_list":["post-113332","post","type-post","status-publish","format-standard","hentry","category-evaluacion-de-farmacos","category-navarra","tag-alfredo-Martinez-ramirez","tag-angel-cedazo-minguez","tag-julen-oyarzabal-santamarina","tag-maria-javier-ramirez-gil","tag-marta-dobarro-bugarin","tag-monica-garcia-alloza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=113332"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113332\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=113332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=113332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=113332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}