{"id":113337,"date":"2018-03-11T10:40:46","date_gmt":"2018-03-11T10:40:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-y-caracterizacion-de-plasmidos-como-soporte-genetico-de-la-carbapenemasa-oxa-40-en-cepas-de-acinetobacter-baumannii\/"},"modified":"2018-03-11T10:40:46","modified_gmt":"2018-03-11T10:40:46","slug":"estudio-y-caracterizacion-de-plasmidos-como-soporte-genetico-de-la-carbapenemasa-oxa-40-en-cepas-de-acinetobacter-baumannii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/antibioticos\/estudio-y-caracterizacion-de-plasmidos-como-soporte-genetico-de-la-carbapenemasa-oxa-40-en-cepas-de-acinetobacter-baumannii\/","title":{"rendered":"Estudio y caracterizaci\u00f3n de pl\u00e1smidos como soporte gen\u00e9tico de la carbapenemasa oxa-40 en cepas de acinetobacter baumannii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ikerne Rosales Gonzalez <\/strong><\/h2>\n<p>La emergencia de a. Baumannii como importante pat\u00f3geno nosocomial ha coincidido con el incremento de cepas resistentes a m\u00faltiples clases de antibi\u00f3ticos.   Hasta hace 10 a\u00f1os, el aislamiento de este tipo de cepas hab\u00eda sido espor\u00e1dico, pero actualmente en algunos pa\u00edses como reino unido, italia, portugal y espa\u00f1a aparecen cepas end\u00e9micas. Desde el a\u00f1o 1999 en nuestro medio se viene detectando la presencia de clones multirresistentes (ec i y ec ii) en infecciones nosocomiales con un alto \u00edndice de morbi-mortalidad. En este aspecto, se ha identificado la presencia de la carbapenemasa oxa-40 en cepas multirresistentes pertenecientes a \u00e9stos clones.  Esta enzima tambi\u00e9n ha sido ampliamente descrita en otros pa\u00edses como portugal, italia, francia y estados unidos. Aunque este microorganismo se considera fuente de acumulaci\u00f3n y transmisi\u00f3n de genes de resistencia, poco se conoce sobre la presencia de pl\u00e1smidos asociados a la diseminaci\u00f3n de la carbapenemasa oxa-40. En el presente trabajo, mediante aislamiento de adn plasm\u00eddico e hibridaci\u00f3n con una sonda espec\u00edfica, se detect\u00f3 la presencia de esta enzima dentro de dos pl\u00e1smidos, denominados pabst40 y pab40, de 9.4 y 32 kb, respectivamente. Al realizar restricci\u00f3n enzim\u00e1tica a ambos pl\u00e1smidos se obtuvo un fragmento bglii-bglii de 2.7 kb que contiene el gen blaoxa-40; al comparar \u00e9ste mapa de restricci\u00f3n con las secuencias de pl\u00e1smidos descritos en otras \u00e1reas geogr\u00e1ficas, comprobamos que la mayor homolog\u00eda se observada con el pl\u00e1smido pab02 descrito parcialmente en 2004 por fosse y cols.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio y caracterizaci\u00f3n de pl\u00e1smidos como soporte gen\u00e9tico de la carbapenemasa oxa-40 en cepas de acinetobacter baumannii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio y caracterizaci\u00f3n de pl\u00e1smidos como soporte gen\u00e9tico de la carbapenemasa oxa-40 en cepas de acinetobacter baumannii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ikerne Rosales Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Sevillano Pe\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>sara Marti marti (vocal)<\/li>\n<li>Francisco Javier Castillo garcia (vocal)<\/li>\n<li>raul Ortiz de lejarazu leonardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ikerne Rosales Gonzalez La emergencia de a. Baumannii como importante pat\u00f3geno nosocomial ha coincidido con el incremento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,12909],"tags":[138100,189255,225123,5148,4947,149887],"class_list":["post-113337","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-pais-vasco-euskal-herriko-unibertsitatea","tag-elena-sevillano-pena","tag-francisco-javier-castillo-garcia","tag-ikerne-rosales-gonzalez","tag-ramon-cisterna-cancer","tag-raul-ortiz-de-lejarazu-leonardo","tag-sara-marti-marti"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=113337"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113337\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=113337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=113337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=113337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}