{"id":113411,"date":"2012-10-11T00:00:00","date_gmt":"2012-10-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-de-los-efectos-del-resveratrol-y-la-irradiacion-sobre-la-viabilidad-apoptosis-migracion-y-el-ciclo-celular-en-el-carcinoma-oral-de-celulas-escamosas\/"},"modified":"2012-10-11T00:00:00","modified_gmt":"2012-10-11T00:00:00","slug":"estudio-in-vitro-de-los-efectos-del-resveratrol-y-la-irradiacion-sobre-la-viabilidad-apoptosis-migracion-y-el-ciclo-celular-en-el-carcinoma-oral-de-celulas-escamosas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/estudio-in-vitro-de-los-efectos-del-resveratrol-y-la-irradiacion-sobre-la-viabilidad-apoptosis-migracion-y-el-ciclo-celular-en-el-carcinoma-oral-de-celulas-escamosas\/","title":{"rendered":"Estudio in vitro de los efectos del resveratrol y la irradiacion sobre la viabilidad, apoptosis, migracion y el ciclo celular en el carcinoma oral de celulas escamosas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Navarro Atienzar <\/strong><\/h2>\n<p>Introducci\u00f3n: el carcinoma oral de c\u00e9lulas escamosas, histol\u00f3gicamente, es el tumor m\u00e1s com\u00fan observado en la cavidad oral.  El resveratrol es un producto antioxidante natural polifen\u00f3lico que, recientemente, ha sido declarado un agente antitumoral y quimiopreventivo.  objetivo: estudio in vitro para evaluar el efecto del resveratrol combinado con la irradiaci\u00f3n, sobre el carcinoma oral humano de c\u00e9lulas escamosas.  material y m\u00e9todos: el resveratrol ha sido administrado en dosis de 5, 10, 25, 50 y 100?M sobre cultivos de la l\u00ednea celular pe\/ca-pj15 de  coce.  resultados: la aplicaci\u00f3n de resveratrol a la l\u00ednea de c\u00e9lulas tumorales  pe\/ca-pj15 con irradiaci\u00f3n ejerce un efecto inhibidor sobre la viabilidad, favorece la activaci\u00f3n de la apoptosis, disminuye la migraci\u00f3n y produce un arresto del ciclo celular.  conclusiones: el resveratrol incrementa la actividad citot\u00f3xica en la l\u00ednea celular pe\/ca-pj15, mientras que la combinaci\u00f3n de resveratrol con irradiaci\u00f3n produce un efecto sin\u00e9rgico en dicha actividad citot\u00f3xica.   palabras clave: resveratrol, coce, in vitro.     background: histologically, the oral squamous cell carcinoma is the most common tumor observed in the oral cavity. Resveratrol is a natural polyphenolic antioxidant product which has been declared as a chemopreventive and antitumor agent.  objective: in vitro study to evaluate the effect of resveratrol combined with irradiation on oral squamous cell carcinoma.  material and methods: resveratrol has been administered in doses of 5, 10, 25, 50 and 100 \u00c2\u00b5m on cultured cell line pe\/ca-pj15 of oscc.  results: the application of resveratrol to the tumor cell line pe\/ca-pj15 with irradiation exerts an inhibition on cell viability, provides a synergistic effect on apoptosis, decreases cell migration and produces arrest in s phase of the cell cycle.  conclusions:  resveratrol increases the cytotoxic activity in cell line pe\/ca-pj15, while the combination of resveratrol with irradiation produces a synergistic effect in such cytotoxic activity.  key words: resveratrol, oscc, in vitro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio in vitro de los efectos del resveratrol y la irradiacion sobre la viabilidad, apoptosis, migracion y el ciclo celular en el carcinoma oral de celulas escamosas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio in vitro de los efectos del resveratrol y la irradiacion sobre la viabilidad, apoptosis, migracion y el ciclo celular en el carcinoma oral de celulas escamosas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Navarro Atienzar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/11\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Pia Lopez Jornet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel jose Saura perez <\/li>\n<li>Marta Camps raga (vocal)<\/li>\n<li>celia Haya fern\u00e1ndez (vocal)<\/li>\n<li>Luis Alberto Moreno lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Navarro Atienzar Introducci\u00f3n: el carcinoma oral de c\u00e9lulas escamosas, histol\u00f3gicamente, es el tumor m\u00e1s com\u00fan observado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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