{"id":113493,"date":"2018-03-11T10:40:57","date_gmt":"2018-03-11T10:40:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-del-factor-de-crecimiento-del-endotelio-vascular-vegf-y-del-lipopolisacarido-lps-de-las-bacterias-gram-negativas-en-la-carcinogenesis-vesical\/"},"modified":"2018-03-11T10:40:57","modified_gmt":"2018-03-11T10:40:57","slug":"valor-pronostico-del-factor-de-crecimiento-del-endotelio-vascular-vegf-y-del-lipopolisacarido-lps-de-las-bacterias-gram-negativas-en-la-carcinogenesis-vesical","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/valor-pronostico-del-factor-de-crecimiento-del-endotelio-vascular-vegf-y-del-lipopolisacarido-lps-de-las-bacterias-gram-negativas-en-la-carcinogenesis-vesical\/","title":{"rendered":"Valor pron\u00f3stico del factor de crecimiento del endotelio vascular (vegf) y del lipopolisac\u00e1rido (lps) de las bacterias gram negativas en la carcinog\u00e9nesis vesical"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Lecumberri Casta\u00f1os <\/strong><\/h2>\n<p>A pesar de los avances en la identificaci\u00f3n de nuevos marcadores moleculares del carcinoma superficial de vejiga, todav\u00eda es dif\u00edcil predecir su comportamiento biol\u00f3gico. Las infecciones urinarias  que coexisten con el desarrollo de los tumores vesicales, aportan lps al microambiente vesical, lo que podr\u00eda estimular la producci\u00f3n de factores proinflamatorios y proangiog\u00e9nicos, incluido vegf, activando la proliferaci\u00f3n e invasi\u00f3n tumoral y contribuyendo a un peor pron\u00f3stico de la enfermedad. Sin embargo se desconoce si vegf y las endotoxinas bacterianas de lipopolisac\u00e1rido (lps), podr\u00edan ser de utilidad en la detecci\u00f3n precoz de recidivas del c\u00e1ncer de vejiga, y en la identificaci\u00f3n de pacientes de mayor riesgo.El presente proyecto cuantific\u00f3 la concentraci\u00f3n urinaria de vegf y lps en una serie de tumores vesicales, analizando su relaci\u00f3n con el estadio, tama\u00f1o tumoral, instilaciones, y n\u00famero de tumores al diagn\u00f3stico, para estudiar su relaci\u00f3n con la existencia de recidiva local precoz en los dos primeros a\u00f1os tras el diagn\u00f3stico.Los resultados obtenidos demostraron que los valores prequir\u00fargicos de vegf en orina constituyen un buen par\u00e1metro indicador de la presencia de tumor y tienen valor predictivo de recidiva precoz en el carcinoma superficial de vejiga. Los niveles precirug\u00eda de lps, mayores en los tumores infitrantes que han progresado desde superficiales, sugieren que el lps podr\u00eda tener validez como marcador de progresi\u00f3n. La posible utilidad del lps como marcador de progresi\u00f3n y su validez pron\u00f3stica de  recidiva en aquellos pacientes de mayor riesgo, permite afirmar que el lps es un marcador molecular de mal pron\u00f3stico en el c\u00e1ncer vesical. Por tanto, la secuencia de variaci\u00f3n apreciada en los niveles urinarios de lps y vegf, en ausencia y presencia de tumor sugiere la implicaci\u00f3n de las infecciones urinarias por g\u00e9rmenes gram negativos en la carcinog\u00e9nesis vesical.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico del factor de crecimiento del endotelio vascular (vegf) y del lipopolisac\u00e1rido (lps) de las bacterias gram negativas en la carcinog\u00e9nesis vesical<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico del factor de crecimiento del endotelio vascular (vegf) y del lipopolisac\u00e1rido (lps) de las bacterias gram negativas en la carcinog\u00e9nesis vesical <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Lecumberri Casta\u00f1os <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Mendez martin <\/li>\n<li>Jes\u00fas Casti\u00f1eiras fern\u00e1ndez (vocal)<\/li>\n<li>francois Peinado ibarra (vocal)<\/li>\n<li>armando Zuluaga gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Lecumberri Casta\u00f1os A pesar de los avances en la identificaci\u00f3n de nuevos marcadores moleculares del carcinoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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