{"id":113537,"date":"2012-11-12T00:00:00","date_gmt":"2012-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-mecanismo-de-liberacion-de-endoglina-soluble-y-su-relevancia-en-homeostasis-vascular\/"},"modified":"2012-11-12T00:00:00","modified_gmt":"2012-11-12T00:00:00","slug":"estudio-del-mecanismo-de-liberacion-de-endoglina-soluble-y-su-relevancia-en-homeostasis-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-del-mecanismo-de-liberacion-de-endoglina-soluble-y-su-relevancia-en-homeostasis-vascular\/","title":{"rendered":"Estudio del mecanismo de liberaci\u00f3n de endoglina soluble y su relevancia en homeostasis vascular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Cristina Valbuena Diez <\/strong><\/h2>\n<p>En mi tesis se investigan los efectos de la hipoxia y sus v\u00edas corriente abajo en la liberaci\u00f3n de seng en la linea celular jar parecida a los trofoblastos. En condiciones de hipoxia, se produce un aumento de la liberaci\u00f3n de seng al medio de cultivo  de las c\u00e9lulas jar en paralelo a una elevada formaci\u00f3n de especies reactivas de ox\u00edgeno (ros). Debido a que este aumento de los niveles de ros generalmente se asocia con la formaci\u00f3n de oxisteroles, se prob\u00f3 como tratamiento el 22-(r)-hidroxicoleste rol (22-r), descrito como un ligando natural de lxr. El tratamiento de las c\u00e9lulas jar con 22-(r) o el agonista sint\u00e9tico de lxr, t0901317 (t09), provoc\u00f3 un claro aumento de la liberaci\u00f3n de seng. La implicaci\u00f3n de la via de lxr se corrobor\u00f3 empleand o fibroblastos embrionarios de rat\u00f3n (mefs) obtenidos de ratones doble ko para lxr transfectados con endoglina humana. Adem\u00e1s, la endoglina humana exprsada en transfectantes estables sufr\u00eda corte proteol\u00edtico cuando estos transfectantes se somet\u00edan a  hipoxia. El tratamiento de las c\u00e9lulas jar con t09 provoca un aumento de la expression de mmp-14 y de su actividad, as\u00ed como una reducci\u00f3n significativa de los niveles de marn y proteina de su inhibidor end\u00f3geno timp-3. La implicaci\u00f3n de la v\u00eda mmp- 14\/timp-3 en la liberaci\u00f3n de  seng se confirm\u00f3 utilizando siarn espec\u00edfico para timp-3, timp-3 recombinante y mmp-14 recombinante. Algunos p\u00e9ptidos relacionados con endoglina que contiene la secuencia consenso de corte para mmp-14, gl, son capaces d e bloquear la liberaci\u00f3n de seng en c\u00e9lulas jar. Adem\u00e1s, cuando se trataron ratones con t09 o 22-r se produce un aumento de los niveles plasm\u00e1ticos de seng, junto con un aumento de la presi\u00f3n arterial sist\u00f3lica (sap). Por otro lado, ratones que sobre -expresan mmp-14 o seng muestran un aumento de sus valores de sap. Finalmente, cuando se administra un peptido de endoglina que contiene el sitio de corte para mmp-14 se evita el aumento de los niveles de seng y de la sap dependiente de los oxisterol es en los ratones. Estos estudios proporcionan algunos datos importantes para entender la implicaci\u00f3n de la via de lxr en la liberaci\u00f3n de seng y su contribuci\u00f3n a la regulaci\u00f3n de la homeostasis vascular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del mecanismo de liberaci\u00f3n de endoglina soluble y su relevancia en homeostasis vascular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del mecanismo de liberaci\u00f3n de endoglina soluble y su relevancia en homeostasis vascular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Cristina Valbuena Diez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmelo Bernabeu Quirante<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<li>Mar\u00eda laura Garc\u00eda bermejo (vocal)<\/li>\n<li>Jos\u00e9 Miguel Lopez novoa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Cristina Valbuena Diez En mi tesis se investigan los efectos de la hipoxia y sus v\u00edas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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