{"id":113546,"date":"2012-12-12T00:00:00","date_gmt":"2012-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-metabolico-y-transcriptomico-en-poblacion-infantil-obesa-tras-una-intervencion-nutricional-para-la-perdida-de-peso\/"},"modified":"2012-12-12T00:00:00","modified_gmt":"2012-12-12T00:00:00","slug":"perfil-metabolico-y-transcriptomico-en-poblacion-infantil-obesa-tras-una-intervencion-nutricional-para-la-perdida-de-peso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-nutricion\/perfil-metabolico-y-transcriptomico-en-poblacion-infantil-obesa-tras-una-intervencion-nutricional-para-la-perdida-de-peso\/","title":{"rendered":"Perfil metab\u00f3lico y transcript\u00f3mico en poblaci\u00f3n infantil obesa tras una intervenci\u00f3n nutricional para la p\u00e9rdida de peso"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tara Rendo Urteaga <\/strong><\/h2>\n<p>Metabolic and transcriptomic profile after a weight loss nutritional intervention in obese children. tara rendo urteaga. School of pharmacy, university of navarra (spain), 2012. the increasing prevalence of childhood obesity makes necessary to intensify obesity treatment. A successful weight loss programme in overweight and obese children and adolescents should be accompanied by a general metabolic improvement and a reduction in several cardiovascular risk factors. The aim of this study was to evaluate the effect of a 10-week intervention program, based on a moderate calorie restriction on metabolic and oxidative stress markers and gene expression profile in peripheral blood mononuclear cells (pbmc) from obese children. For this purpose, forty-four overweight\/obese children (mean age 11.5 years; 50% males) were enrolled in a 10-week weight loss programme. Subjects were dichotomized by the median of body mass index-standard deviation score (bmi-sds) change as high (hr) and low responders (lr) at the end of the weight loss programme.  these results suggest that a lower decrease in dietary total antioxidant capacity (tac) after the intervention may predict a greater weight loss in obese children with a good response to the diet. Furthermore, a better serum antioxidant-oxidant balance before a weight loss treatment could predict a better weight loss response. On the other hand, we showed, for the first time, a reduction in serum cardiotrophin-1 levels after a weight loss programme and that this decrease in cardiotrophin-1 was strongly associated with lower cholesterol levels in overweight\/obese children. Finally, the study confirms that pbmc gene expression changes in obese boys may help to understand the weight loss response.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perfil metab\u00f3lico y transcript\u00f3mico en poblaci\u00f3n infantil obesa tras una intervenci\u00f3n nutricional para la p\u00e9rdida de peso<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perfil metab\u00f3lico y transcript\u00f3mico en poblaci\u00f3n infantil obesa tras una intervenci\u00f3n nutricional para la p\u00e9rdida de peso <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tara Rendo Urteaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amelia Angela Marti Del Moral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  pilar Fernandez otero <\/li>\n<li>Mar\u00eda teresa Macarulla arenaza (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas Chueca guindulain (vocal)<\/li>\n<li>josep antoni Tur mar\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tara Rendo Urteaga Metabolic and transcriptomic profile after a weight loss nutritional intervention in obese children. tara [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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