{"id":113593,"date":"2018-03-11T10:41:08","date_gmt":"2018-03-11T10:41:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-las-bases-genetico-moleculares-y-ambientales-relacionadas-con-la-variabilidad-interindividual-en-la-respuesta-a-anti-tnf-en-pacientes-con-enfermedad-inflamatoria-intestinal\/"},"modified":"2018-03-11T10:41:08","modified_gmt":"2018-03-11T10:41:08","slug":"caracterizacion-de-las-bases-genetico-moleculares-y-ambientales-relacionadas-con-la-variabilidad-interindividual-en-la-respuesta-a-anti-tnf-en-pacientes-con-enfermedad-inflamatoria-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/caracterizacion-de-las-bases-genetico-moleculares-y-ambientales-relacionadas-con-la-variabilidad-interindividual-en-la-respuesta-a-anti-tnf-en-pacientes-con-enfermedad-inflamatoria-intestinal\/","title":{"rendered":"Caracterizaci\u00f3n de las bases gen\u00e9tico-moleculares y ambientales relacionadas con la variabilidad interindividual en la respuesta a anti-tnf en pacientes con enfermedad inflamatoria intestinal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diana Lacruz Guzman <\/strong><\/h2>\n<p>Objetivo: investigar la relaci\u00f3n entre la respuesta a los tratamientos anti-tnf en pacientes con eii y factores gen\u00e9ticos y ambientales. m\u00e9todo: estudio longitudinal de todos los pacientes con eii de un hospital universitario, en tratamiento con terapias anti-tnf. La respuesta al tratamiento se determin\u00f3 mediante el uso del cuestionario cdai (enfermedad de crohn), y la determinaci\u00f3n de las concentraciones s\u00e9ricas de prote\u00edna c reactiva. Los factores gen\u00e9ticos y bioqu\u00edmicos se estudiaron mediante la identificaci\u00f3n de polimorfismos tipo snp y medici\u00f3n de concentraciones s\u00e9ricas de diversas citocinas. resultados: los pacientes con cu presentaron una mayor concentraci\u00f3n s\u00e9rica basal de citocinas (il1, il6, tnf?) Que los pacientes con ec. Se observ\u00f3 asociaci\u00f3n entre una mayor concentraci\u00f3n s\u00e9rica de il1 y el genotipo cc del polimorfismo rs1143634 del gen de la il1b. El alelo g del polimorfismo rs767455 del gen del tnfr1a mostr\u00f3 asociaci\u00f3n con no respuesta cl\u00ednica en pacientes con ec.  palabras clave: enfermedad inflamatoria intestinal, factores gen\u00e9ticos, respuesta, infliximab    objective: to investigate the relationship between the response to anti-tnf treatment in patients with ibd and genetic and environmental factors. method: longitudinal study of all patients with ibd in a university hospital, treated with anti-tnf therapies. The response to treatment was determined by using the questionnaire cdai (crohn&apos;s disease), and determination of serum c-reactive protein. Biochemical and genetic factors were studied by identifying polymorphisms snp type and measuring serum concentrations of various cytokines. results: patients with uc had a higher baseline serum cytokines (il1, il6, tnf) that patients with cd. Association was observed between increased serum il1 and cc genotype rs1143634 polymorphism il1b gene. The g allele of rs767455 polymorphism tnfr1a gene showed no association with clinical response in patients with cd.  key words: inflammatory bowel disease, genetic factors, response, infliximab.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de las bases gen\u00e9tico-moleculares y ambientales relacionadas con la variabilidad interindividual en la respuesta a anti-tnf en pacientes con enfermedad inflamatoria intestinal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de las bases gen\u00e9tico-moleculares y ambientales relacionadas con la variabilidad interindividual en la respuesta a anti-tnf en pacientes con enfermedad inflamatoria intestinal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diana Lacruz Guzman <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2012<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Vicente Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Perez-guillermo garcia <\/li>\n<li>senador Mor\u00e1n s\u00e1nchez (vocal)<\/li>\n<li>pablo Carbonell meseguer (vocal)<\/li>\n<li>enrique Poblet Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diana Lacruz Guzman Objetivo: investigar la relaci\u00f3n entre la respuesta a los tratamientos anti-tnf en pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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