{"id":113742,"date":"2018-03-11T10:41:25","date_gmt":"2018-03-11T10:41:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-predictivo-para-la-recidiva-bioqua%c2%admica-en-los-pacientes-con-cancer-de-prostata-localizado-tratados-con-prostatectoma%c2%ada-radical-en-monoterapia\/"},"modified":"2018-03-11T10:41:25","modified_gmt":"2018-03-11T10:41:25","slug":"modelo-predictivo-para-la-recidiva-bioqua%c2%admica-en-los-pacientes-con-cancer-de-prostata-localizado-tratados-con-prostatectoma%c2%ada-radical-en-monoterapia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelo-predictivo-para-la-recidiva-bioqua%c2%admica-en-los-pacientes-con-cancer-de-prostata-localizado-tratados-con-prostatectoma%c2%ada-radical-en-monoterapia\/","title":{"rendered":"Modelo predictivo para la recidiva bioqu\u00edmica en los pacientes con c\u00e1ncer de pr\u00f3stata localizado tratados con prostatectom\u00edaradical en monoterapia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roberto Molina Escudero <\/strong><\/h2>\n<p>Objetivos: identificar los factores pron\u00f3sticos pre y post-prostatectom\u00eda de recidiva bioqu\u00edmica (rb) y elaborar un modelo predictivo para la rb basado en variables predictivas cl\u00ednicas y patol\u00f3gicas tras prostatectom\u00eda radical (pr).  material y meto dos: analizamos retrospectivamente los pacientes con c\u00e1ncer de pr\u00f3stata cl\u00ednicamente localizado tratados con pr en monoterapia y seguimiento m\u00ednimo de 12 meses, entre 1996 y 2007. Consideramos como rb la persistencia o elevaci\u00f3n del psa > 0,4 ng\/ml t ras la pr  realizamos un an\u00e1lisis uni y multivariante mediante chi cuadrado y regresi\u00f3n log\u00edstica para determinar las variables asociadas con la rb.  desarrollamos un modelo matem\u00e1tico para estimar la rb con las variables identificadas, seg\u00fan la ecua ci\u00f3n de funci\u00f3n log\u00edstica y dise\u00f1amos una hoja de c\u00e1lculo en excel para su aplicaci\u00f3n. Realizamos la calibraci\u00f3n y discriminaci\u00f3n mediante la prueba de hosmer-lemeshow y el \u00e1rea bajo la curva roc. resultados: incluimos 693 pacientes. La edad media fu e 63,5 a\u00f1os y el seguimiento medio 88,5 meses. 218  pacientes presentaron rb. El tiempo medio hasta la rb fue 35,5 meses, produci\u00e9ndose el 91,2  en los 8 primeros a\u00f1os. En el an\u00e1lisis multivariante el psa y el sg bi\u00f3psico (sgb) resultaron variables c l\u00ednicas independientes relacionadas con la rb (p\u00ed\u00a70,001), el estadio ct2c present\u00f3 tendencia a la significaci\u00f3n (p=0,07). El  sg ? 7(4 3), el estadio pt3b y el margen quir\u00fargico positivo (mqp) resultaron variables patol\u00f3gicas independientes relacionad as con la rb (p\u00ed\u00a70,001).   la sensibilidad, especificidad y exactitud global fueron 93,6 , 36,8  y 75,1  para el modelo preoperatorio y 90,6 , 50,2  y 77,3  para el postoperatorio. La capacidad predictiva de ambos modelos fue del 73  y 80,5  respectiv amente. conclusiones: el psa, sgb, sg ? 7(4 3), estadio pt3b y mqp, son las variables pronosticas independientes relacionadas con la rb. El modelo predictivo desarrollado permite estimar con una fiabilidad del  73  y 80,5  el riesgo de rb.  palabras clave: recidiva bioqu\u00edmica; modelo predictivo; prostatectom\u00eda radical; c\u00e1ncer de pr\u00f3stata.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo predictivo para la recidiva bioqu\u00edmica en los pacientes con c\u00e1ncer de pr\u00f3stata localizado tratados con prostatectom\u00edaradical en monoterapia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo predictivo para la recidiva bioqu\u00edmica en los pacientes con c\u00e1ncer de pr\u00f3stata localizado tratados con prostatectom\u00edaradical en monoterapia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roberto Molina Escudero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/01\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felipe Bernardo Herranz Amo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe angel Calvo manuel <\/li>\n<li>carmen Gonz\u00e1lez enguita (vocal)<\/li>\n<li>\u00e1lvaro Pa\u00e9z borda (vocal)<\/li>\n<li>joaqu\u00edn Carballido rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roberto Molina Escudero Objetivos: identificar los factores pron\u00f3sticos pre y post-prostatectom\u00eda de recidiva bioqu\u00edmica (rb) y elaborar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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