{"id":113749,"date":"2018-03-11T10:41:25","date_gmt":"2018-03-11T10:41:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetic-and-environmental-contributions-to-obesity-in-roma-population-influencia-de-los-factores-geneticos-y-ambientales-en-la-obesidad-en-poblacion-gitana\/"},"modified":"2018-03-11T10:41:25","modified_gmt":"2018-03-11T10:41:25","slug":"genetic-and-environmental-contributions-to-obesity-in-roma-population-influencia-de-los-factores-geneticos-y-ambientales-en-la-obesidad-en-poblacion-gitana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/antropologia-fisica\/genetic-and-environmental-contributions-to-obesity-in-roma-population-influencia-de-los-factores-geneticos-y-ambientales-en-la-obesidad-en-poblacion-gitana\/","title":{"rendered":"Genetic and environmental contributions to obesity in roma population\/influencia de los factores gen\u00e9ticos y ambientales en la obesidad en poblaci\u00f3n gitana"},"content":{"rendered":"

Tesis doctoral de Alaitz Poveda Zabala <\/strong><\/h2>\n

The prevalence of overweight and obesity has increased over several decades in allage groups and most countries worldwide. Such increases have a high impact in publichealth since obesity increases the risk of a number of several chronic diseases (e.G.Hypertension). Understanding the genetic and environmental factors contributing to obesityand hypertension has thus a substantial interest. The roma people due to their particularsocial and ethnic characteristics may provide very interesting information in this area. Inthe present work a sample of 50 extended families from the roma population of thegreater bilbao region was employed in order to study the role of genetic andenvironmental factors on the variability of body morphology, obesity and blood pressurephenotypes. A high prevalence of obesity was detected in adults and minors of the romapopulation. In addition, the majority of the studied adult individuals underestimated theiractual body size. A remarkably high heritability for abdominal fat accumulation was shownin the present study (h2whr= 0.60). Concerning the relationship between adiposity andblood pressure measurements, although apparently these phenotypes do not share asubstantial common genetic background, shared environmental factors significantly affectthe covariation between them. Waist circumference was the obesity-related trait mostgenetically correlated with bp traits which highlights the importance of this measurementon the determination of the risk of obesity-related diseases. On the other hand, the resultsobtained in this research have concluded that lifestyle and socioeconomic factors have aslight but significant influence on obesity-related traits, somatotype components and bloodpressure phenotypes. Roma individuals of higher ses tended to have more body mass andfat, a pattern frequently found in developing countries. In addition, higher levels of physicalactivity, lower levels of sedentary activities, such as tv viewing, and greater number ofsleep hours and daily meals were associated with lower adiposity accumulation and bloodpressure. Finally, family-based association tests revealed that snps in or near six genes(negr1, sh2b1, bdnf, mc4r, kctd15 and faim2) were significantly associated withbody morphology and obesity-related traits in roma people. However, no significantassociations were detected between studied anthropometric phenotypes and geneticvariants in fto gene, which showed the strongest associations with obesity in othercaucasian (european) origin populations.En las \u00faltimas d\u00e9cadas, la preValencia del sobrepeso y la obesidad se haincrementado en todos los rangos de edad y en la mayor\u00eda de los pa\u00edses. Este incrementotiene un gran impacto en la salud p\u00fablica debido al riesgo asociado a la obesidad de padeceruna serie de enfermedades cr\u00f3nicas como la hipertensi\u00f3n. Por tanto, conocer los factoresgen\u00e9ticos y ambientales que influyen el desarrollo de la obesidad y la hipertensi\u00f3n resulta degran inter\u00e9s. La poblaci\u00f3n gitana debido a sus particulares caracter\u00edsticas \u00e9tnicas y socialespuede aportar una informaci\u00f3n muy valiosa en este \u00e1rea. En el presente trabajo se emple\u00f3una muestra compuesta por 50 familias extendidas pertenecientes a poblaci\u00f3n gitanaresidente en el gran bilbao para estudiar los factores gen\u00e9ticos y ambientales que influyenen la variabilidad de la morfolog\u00eda corporal, la obesidad y la presi\u00f3n arterial. Se detect\u00f3 unaalta preValencia de obesidad tanto en adultos como en menores de edad en la poblaci\u00f3nestudiada. Asimismo se observ\u00f3 que la mayor\u00eda de los adultos de etnia gitana estudiadossubestiman su tama\u00f1o corporal, un aspecto preocupante habida cuenta de las altas tasas deobesidad observadas. Adem\u00e1s, en el presente estudio se encontr\u00f3 una heredabilidadsorprendentemente alta para la acumulaci\u00f3n de grasa en la zona abdominal (h2icc= 0.60).En cuanto a la relaci\u00f3n entre la adiposidad y la presi\u00f3n arterial, estos fenotipos no parecencompartir unas influencias gen\u00e9ticas comunes, sin embargo los factores ambientalescomunes influyen significativamente en la covariaci\u00f3n entre ambos. La circunferencia de lacintura fue la variable que mayor correlaci\u00f3n gen\u00e9tica mostr\u00f3 con las medidas de presi\u00f3narterial, lo que demuestra la importancia de este rasgo en la determinaci\u00f3n del riesgo depadecer enfermedades relacionadas con la obesidad. Por otro lado, los resultados obtenidosen este estudio concluyeron que los factores socioecon\u00f3micos y del estilo de vida tienenuna influencia peque\u00f1a pero significativa en la acumulaci\u00f3n y distribuci\u00f3n de grasa, en elsomatotipo antropom\u00e9trico y en la presi\u00f3n arterial. Los individuos de etnia gitana quepresentan un estatus socioecon\u00f3mico m\u00e1s alto presentaron una mayor acumulaci\u00f3n degrasa, patr\u00f3n que se ha encontrado frecuentemente en los pa\u00edses en v\u00edas de desarrollomientras que los pa\u00edses desarrollados muestran el patr\u00f3n contrario. La mayor actividadf\u00edsica, la menor dedicaci\u00f3n a actividades sedentarias como ver la televisi\u00f3n, el dormir unmayor n\u00famero de horas y realizar un mayor n\u00famero de ingestas diarias se asociaron conuna menor acumulaci\u00f3n de grasa corporal y a una menor presi\u00f3n arterial en la poblaci\u00f3nestudiada. Por \u00faltimo, los test de asociaci\u00f3n gen\u00e9tica basados en familias revelaron quesnps en o cerca de seis genes (negr1, sh2b1, bdnf, mc4r, kctd15 y faim2) est\u00e1nsignificativamente asociados a la morfolog\u00eda corporal y a los rasgos relacionados con laobesidad en poblaci\u00f3n gitana. Sin embargo, no se encontr\u00f3 una asociaci\u00f3n gen\u00e9tica entreestos fenotipos antropom\u00e9tricos y las variantes del gen fto que es el que habitualmentepresenta una mayor asociaci\u00f3n con los fenotipos de la obesidad en otras poblaciones deorigen caucasoide (europeo).<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abGenetic and environmental contributions to obesity in roma population\/influencia de los factores gen\u00e9ticos y ambientales en la obesidad en poblaci\u00f3n gitana<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Genetic and environmental contributions to obesity in roma population\/influencia de los factores gen\u00e9ticos y ambientales en la obesidad en poblaci\u00f3n gitana <\/li>\n
  • Autor:<\/strong>\u00a0 Alaitz Poveda Zabala <\/li>\n
  • Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2013<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Esther Rebato Ochoa<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: rosario Calderon fernandez <\/li>\n
        • karri Silventoinen (vocal)<\/li>\n
        • daniel Turbon borrega (vocal)<\/li>\n
        • Luis Casis saenz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Alaitz Poveda Zabala The prevalence of overweight and obesity has increased over several decades in allage groups […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[922,12909],"tags":[225766,14242,85881,206803,13402,6672],"class_list":["post-113749","post","type-post","status-publish","format-standard","hentry","category-antropologia-fisica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alaitz-poveda-zabala","tag-daniel-turbon-borrega","tag-esther-rebato-ochoa","tag-karri-silventoinen","tag-luis-casis-saenz","tag-rosario-calderon-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=113749"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/113749\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=113749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=113749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=113749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}