{"id":113759,"date":"2018-03-11T10:41:25","date_gmt":"2018-03-11T10:41:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/imagen-por-espectrometria-de-masas-maldi-ims-para-la-deteccion-de-biomoleculas-y-farmacos\/"},"modified":"2018-03-11T10:41:25","modified_gmt":"2018-03-11T10:41:25","slug":"imagen-por-espectrometria-de-masas-maldi-ims-para-la-deteccion-de-biomoleculas-y-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-fisica\/imagen-por-espectrometria-de-masas-maldi-ims-para-la-deteccion-de-biomoleculas-y-farmacos\/","title":{"rendered":"Imagen por espectrometr\u00eda de masas (maldi-ims) para la detecci\u00f3n de biomol\u00e9culas y f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Veloso Fernandez <\/strong><\/h2>\n<p>Este trabajo supone un avance metodol\u00f3gico sobre la t\u00e9cnica de espectrometr\u00eda de masas maldi para la detecci\u00f3n de biomol\u00e9culas y f\u00e1rmacos en muestras biol\u00f3gicas y en secciones de tejido de rat\u00f3n, rata y humano.Actualmente, se est\u00e1 generalizando el empleo de la t\u00e9cnica de imagen por espectrometr\u00eda de masas maldi-ims para la detecci\u00f3n de mol\u00e9culas biol\u00f3gicas. La preparaci\u00f3n de la muestra es un paso cr\u00edtico en esta t\u00e9cnica y requiere de gran habilidad para obtener  im\u00e1genes de buena calidad. Se ha desarrollado y mejorado maldi-ims aplicada al an\u00e1lisis lip\u00eddico en tejido de h\u00edgado quiescente y regenerante de rat\u00f3n, cerebro y m\u00e9dula espinal de rata, cerebro humano postmortem; as\u00ed como en placas tlc con  separaci\u00f3n de especies lip\u00eddicas. En el caso del cerebro humano se escogieron \u00e1reas de corteza frontal, hipocampo y estriado, todas ellas implicadas en enfermedades neurodegenerativas como el alzheimer. Por otra parte, debido a las limitaciones que presentan las t\u00e9cnicas utilizadas en la actualidad para la detecci\u00f3n y localizaci\u00f3n anat\u00f3mica de f\u00e1rmacos (aislamiento del f\u00e1rmaco y marcado mediante sondas, generalmente radiactivas), se ha realizado la detecci\u00f3n in vitro de biomol\u00e9culas implicadas en la neurotransmisi\u00f3n, realiz\u00e1ndose incubaciones de los f\u00e1rmacos sobre tejido cerebral de rata para observar las uniones espec\u00edficas de cada f\u00e1rmaco.Por \u00faltimo, dado que las matrices maldi pueden dificultar la detecci\u00f3n de mol\u00e9culas de peso molecular menor a 500 da, se estudiaron alternativas a estas matrices convencionales para la detecci\u00f3n e identificaci\u00f3n de f\u00e1rmacos y l\u00edpidos en muestras biol\u00f3gicas. Para ello, se utilizaron sustancias que no interfieren en la detecci\u00f3n de los analitos y m\u00e9todos libre de matriz.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Imagen por espectrometr\u00eda de masas (maldi-ims) para la detecci\u00f3n de biomol\u00e9culas y f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Imagen por espectrometr\u00eda de masas (maldi-ims) para la detecci\u00f3n de biomol\u00e9culas y f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Veloso Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Rodriguez Puertas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bego\u00f1a Ochoa olascoaga <\/li>\n<li>Mar\u00eda  cristina B\u00ed\u00a4ckman higuera (vocal)<\/li>\n<li>roser Cortes colome (vocal)<\/li>\n<li>Jos\u00e9 Miguel Vadillo perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Veloso Fernandez Este trabajo supone un avance metodol\u00f3gico sobre la t\u00e9cnica de espectrometr\u00eda de masas maldi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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