{"id":11379,"date":"2018-03-09T08:56:43","date_gmt":"2018-03-09T08:56:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-senalizacion-y-regulacion-de-receptores-de-quimioquinas\/"},"modified":"2018-03-09T08:56:43","modified_gmt":"2018-03-09T08:56:43","slug":"mecanismos-de-senalizacion-y-regulacion-de-receptores-de-quimioquinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-senalizacion-y-regulacion-de-receptores-de-quimioquinas\/","title":{"rendered":"Mecanismos de se\u00f1alizacion y regulacion de receptores de quimioquinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jimenez Sainz M. Carmen <\/strong><\/h2>\n<p>En esta tesis doctoral se describen nuevos mecanismos de se\u00f1alizaci\u00f3n y regulaci\u00f3n de receptores de quimioquinas. Estos receptores desempe\u00f1an un papel muy importante los procesos de migraci\u00f3n, desarrollo y diferenciaci\u00f3n de distintas poblaciones leucocitarias, as\u00ed como tambi\u00e9n est\u00e1n implicados en el desarrollo de diversas patolog\u00edas como asma, artritis reumatoide, esclerosis m\u00faltiple o infecci\u00f3n por vih-1. El estudio con el receptor de quimioquinas ccr2b ha demostrado la implicacion de la quinasa grk2 en los mecanismos de la desensibilizaci\u00f3n de la se\u00f1al de calcio mediada por el mismo tras su estimulacion com mcp-1. Esta quinasa es capaz de fosforilar a este receptor en residuos de serina y treonina en su extremo c-terminal, sin embargo la isoforma ccr2a de este receptor se fosforila en menor grado que ccr2b. La internalizaci\u00f3n de estos receptores se regula por la prote\u00edna b-arrestina 1, aunque la afinidad de estos receptores por la otra isoforma de esta failia de proteinas desacoplantes b-arrestina2 es distinta, puesto que solo ccr2b es capaz de promover una redistribucion de esta proteina, tras su estimulaci\u00f3n con mcp-1. Estos estudios se han realizado mediante an\u00e1lisis de fosforilaci\u00f3n in vitro con la quinasa recombinante, asi como por estudios de microscop\u00eda confocal y coinmunoprecipitaci\u00f3n.  adem\u00e1s el estudio de las prote\u00ednas implicadas en la activaci\u00f3n de la v\u00eda de erk a trav\u00e9s de ccr2b indica la participaci\u00f3n de las prote\u00ednas pkc y pi3k, as\u00ed como la gtpasas dinamina y ras. Aunque en estos procesos no es indispensable la internalizaci\u00f3n del receptor, s\u00ed que la via es modulada negativamente por la quinasa grk2 tanto de manera dependiente como independiente de fosforilaci\u00f3n del receptor. Estos analisis se llevaron a cabo mediante reconocimiento de la forma fosforilada y por tanto activa de erk en c\u00e9lulas transfectadas con el receptor y la quinasa, y se confirmaron en l\u00ednas celulares que expresan el rec<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de se\u00f1alizacion y regulacion de receptores de quimioquinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de se\u00f1alizacion y regulacion de receptores de quimioquinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jimenez Sainz M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Mayor Menendez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel (secretario) Redondo moya <\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li>mario Mellado garcia (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jimenez Sainz M. Carmen En esta tesis doctoral se describen nuevos mecanismos de se\u00f1alizaci\u00f3n y regulaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[6285,14425,37392,37393,37394],"class_list":["post-11379","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-federico-mayor-menendez","tag-francisco-sanchez-madrid","tag-jimenez-sainz-m-carmen","tag-juan-miguel-secretario-redondo-moya","tag-mario-mellado-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11379"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11379\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}