{"id":113808,"date":"2013-08-02T00:00:00","date_gmt":"2013-08-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-cardiovasculares-de-los-estrogenos-en-un-modelo-experimental-de-menopausia-papel-del-oxido-na%c2%adtrico-endotelial-y-angiotensina-ii\/"},"modified":"2013-08-02T00:00:00","modified_gmt":"2013-08-02T00:00:00","slug":"efectos-cardiovasculares-de-los-estrogenos-en-un-modelo-experimental-de-menopausia-papel-del-oxido-na%c2%adtrico-endotelial-y-angiotensina-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/efectos-cardiovasculares-de-los-estrogenos-en-un-modelo-experimental-de-menopausia-papel-del-oxido-na%c2%adtrico-endotelial-y-angiotensina-ii\/","title":{"rendered":"Efectos cardiovasculares de los estr\u00f3genos en un modelo experimental de menopausia: papel del \u00f3xido n\u00edtrico  endotelial y angiotensina ii."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Luis Delgado Marin <\/strong><\/h2>\n<p>Realizamos estudios hemodin\u00e1micos in vivo, in vitro con anillos a\u00f3rticos y estudios bioqu\u00edmicos sobre 3 grupos: ratas sd castradas, con operaci\u00f3n simulada y castradas con tratamiento sustitutivo con 17bestradiol. la ovariectom\u00eda indujo un incremento de la presi\u00f3n arterial y disminuci\u00f3n del \u00edndice card\u00edaco, acompa\u00f1ados de una alteraci\u00f3n de la vasodilataci\u00f3n arterial por disfunci\u00f3n  endotelial. Esta alteraci\u00f3n parece deberse a una disminuci\u00f3n en la liberaci\u00f3n de \u00f3xido n\u00edtrico (no) y a un alteraci\u00f3n del estado redox. La terapia de sustituci\u00f3n con 17bestradiol previno los cambios hemodin\u00e1micos observados tras la ovariectom\u00eda, y restaur\u00f3 la funci\u00f3n de no y el estado redox.  tras bloqueo de la s\u00edntesis de no, la administraci\u00f3n directa de estradiol increment\u00f3 las resistencias vasculares sist\u00e9micas, mediado por una potenciaci\u00f3n end\u00f3gena de la acci\u00f3n de la angiotensina ii.  la administraci\u00f3n precoz de 17bestradiol tras la ovariectom\u00eda es beneficiosa para el sistema cardiovascular, pero en situaciones de disfunci\u00f3n endotelial es perjudicial.  palabras clave: menopausia &#8211; estradiol &#8211; \u00f3xido n\u00edtrico &#8211; angiotensina &#8211; cardiovascular &#8211; endotelio  abstract  we did haemodynamic studies in vivo, in vitro with aortic rings and biochemical studies on three groups: sd ovariectomized rats, sham-operated rats and ovariectomized rats with 17bestradiol replacement therapy. ovariectomy induced hypertension and decreased cardiac index, accompanied by an alteration of arterial vasodilation secondary to an endothelial dysfunction. This disorder appears to be due to a decrease in the release of nitric oxide (no) and an alteration of redox state. 17bestradiol replacement therapy prevented hemodynamic changes observed after ovariectomy, and restored the function of no and redox state. after blocking the synthesis of no, the direct administration of estradiol increased systemic vascular resistance mediated by potentiation of the action of endogenous angiotensin ii.  early administration of 17bestradiol after ovariectomy is beneficial to the cardiovascular system, but in situation of endothelial dysfunction is detrimental.  key words: menopause &#8211; estradiol &#8211; nitric oxide &#8211; angiotensine &#8211; cardiovascular &#8211; endothelium<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos cardiovasculares de los estr\u00f3genos en un modelo experimental de menopausia: papel del \u00f3xido n\u00edtrico  endotelial y angiotensina ii.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos cardiovasculares de los estr\u00f3genos en un modelo experimental de menopausia: papel del \u00f3xido n\u00edtrico  endotelial y angiotensina ii. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Luis Delgado Marin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/02\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 Parrilla Paricio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lorenzo Abad Martinez <\/li>\n<li>alfredo Perales mar\u00edn (vocal)<\/li>\n<li>gabriel Fiol ruiz (vocal)<\/li>\n<li>Antonio Cano s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Luis Delgado Marin Realizamos estudios hemodin\u00e1micos in vivo, in vitro con anillos a\u00f3rticos y estudios bioqu\u00edmicos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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