{"id":113852,"date":"2018-03-11T10:41:31","date_gmt":"2018-03-11T10:41:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-del-cord-factor-de-micobacterias-ata%c2%adpicas-y-relacion-con-la-capacidad-de-induccion-de-diversas-citoquinas-de-relevancia-en-tuberculosis\/"},"modified":"2018-03-11T10:41:31","modified_gmt":"2018-03-11T10:41:31","slug":"estructura-del-cord-factor-de-micobacterias-ata%c2%adpicas-y-relacion-con-la-capacidad-de-induccion-de-diversas-citoquinas-de-relevancia-en-tuberculosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia\/estructura-del-cord-factor-de-micobacterias-ata%c2%adpicas-y-relacion-con-la-capacidad-de-induccion-de-diversas-citoquinas-de-relevancia-en-tuberculosis\/","title":{"rendered":"Estructura del \u00abcord factor\u00bb de micobacterias at\u00edpicas y relaci\u00f3n con la capacidad de inducci\u00f3n de diversas citoquinas de relevancia en tuberculosis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Linares Perez <\/strong><\/h2>\n<p>La capacidad de inducci\u00f3n de diversas citoquinas de relevancia en tuberculosis por parte del &apos;cord factor&apos; (dimicolato de trehalosa) de distintas micobacterias at\u00edpicas (m. Alvei, m. Brumae, m. Fortuitum, m. Simiae) se ha estudiado en las l\u00edneas celulares raw 264.7 y thp-1, compar\u00e1ndose con la del &apos;cord factor&apos; de m. Tuberculosis h37rv, en donde este glicol\u00edpido est\u00e1 implicado en la patog\u00e9nesis de la tuberculosis. La estructura fina de los distintos &apos;cord factors&apos; se estableci\u00f3 mediante resonancia magn\u00e9tica nuclear y espectromentr\u00eda de masas y la actividad biol\u00f3gica se determin\u00f3 mediante t\u00e9cnicas inmuno-enzim\u00e1ticas. Todos los &apos;cord factors&apos; ensayados estimularon la secreci\u00f3n de las citoquinas citadas, predominando tnf-  e il-1  en micobacterias at\u00edpicas e il-6 e il-12p40 en m. Tuberculosis h37rv. Los resultados obtenidos parecen deberse a las diferencias globales detectadas en la composici\u00f3n lip\u00eddica del &apos;cord factor&apos; y podr\u00edan ser de inter\u00e9s al considerar el poder adyuvante de este compuesto. palabras clave: mycobacterium, l\u00edpidos, &apos;cord factor&apos;, actividad biol\u00f3gica, citoquinas. abstract the ability to induce several cytokines relevant in tuberculosis by cord factors (trehalose dimycolate) from atypical mycobacteria (m. Alvei, m. Brumae, m. Fortuitum, m. Simiae) was studied in the cell lines raw 264.7 and thp-1, and compared to that of cord factor from m. Tuberculosis h37rv, where this glycolipid appears implicated in the pathogenesis of tuberculosis. Details of the fine structure of these molecules were obtained by nuclear magnetic resonance and mass spectrometry, and the biological activity by elisa. The data obtained indicated that cord factors from the atypical mycobacteria stimulated the secretion of the indicated cytokines (mostly il-1  and tnf- ), and showed differences with those of m. Tuberculosis h37rv (mostly il-6 and il-12p40). This finding seems due to their particular mycoloyl substituents and could be of interest when considering the potential adjuvanticity of these molecules. key words: mycobacterium, lipids, cord factor, biological activity, cytokines.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura del \u00abcord factor\u00bb de micobacterias at\u00edpicas y relaci\u00f3n con la capacidad de inducci\u00f3n de diversas citoquinas de relevancia en tuberculosis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura del \u00abcord factor\u00bb de micobacterias at\u00edpicas y relaci\u00f3n con la capacidad de inducci\u00f3n de diversas citoquinas de relevancia en tuberculosis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Linares Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/02\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Luis Valero Guillen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Segovia hernandez <\/li>\n<li>Juan  Luis Mu\u00f1oz bellido (vocal)<\/li>\n<li>Mar\u00eda francisca Colom valiente (vocal)<\/li>\n<li>marina Luquin fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Linares Perez La capacidad de inducci\u00f3n de diversas citoquinas de relevancia en tuberculosis por parte del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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