{"id":113958,"date":"2018-03-11T10:41:43","date_gmt":"2018-03-11T10:41:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/opy2-un-nuevo-elemento-implicado-en-la-senalizacion-va%c2%ada-quinasas-de-tipo-map-en-el-hongo-patogeno-candida-albicans\/"},"modified":"2018-03-11T10:41:43","modified_gmt":"2018-03-11T10:41:43","slug":"opy2-un-nuevo-elemento-implicado-en-la-senalizacion-va%c2%ada-quinasas-de-tipo-map-en-el-hongo-patogeno-candida-albicans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/opy2-un-nuevo-elemento-implicado-en-la-senalizacion-va%c2%ada-quinasas-de-tipo-map-en-el-hongo-patogeno-candida-albicans\/","title":{"rendered":"Opy2, un nuevo elemento implicado en la se\u00f1alizaci\u00f3n v\u00edaquinasas de tipo map en el hongo pat\u00f3geno candida albicans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Mar\u00eda Herrero De Dios <\/strong><\/h2>\n<p>En organismos pat\u00f3genos oportunistas para el hombre como candida albicans, la adaptaci\u00f3n al entorno cambiante permite su perpetuaci\u00f3n en el organismo y contribuye a su capacidad de pasar de comensal a pat\u00f3geno. C. Albicans requiere para su adaptaci\u00f3n  y patogenicidad de las rutas de transducci\u00f3n de se\u00f1ales mediadas por quinasas activadas por mit\u00f3genos (mapks). Las rutas de mapks son consideradas factores de virulencia y constituyen aut\u00e9nticas redes de prote\u00ednas interconectadas de gran complejidad . El estudio de la prote\u00edna transmembrana opy2 ha revelado su importante funci\u00f3n en la ruta mediada por la map quinasa cek1, implicada entre otros en virulencia y mantenimiento de la pared celular. Opy2 constituye un elemento de anclaje clave para la  activaci\u00f3n de la ruta cek1 en condiciones de estr\u00e9s causado por diferentes compuestos en la pared celular as\u00ed como para la repuesta mediada por fen\u00f3menos de quorum sensing. La deleci\u00f3n de elementos de las rutas hog y cek1 al mismo tiempo (mutante ss k1 msb2 sho1 opy2) provoca c\u00e9lulas aberrantes con crecimiento isotr\u00f3pico, fragmentaci\u00f3n del material gen\u00e9tico, engrosamientos de quitina localizados en el septo y la pared celular lateral y localizaci\u00f3n err\u00f3nea de cdc10 en medios hiperosmolares, asoc iado a una dr\u00e1stica disminuci\u00f3n de la viabilidad. Presentan asimismo un incremento en el contenido total de l\u00edpidos dependiente de la ruta hog. El empeoramiento de los fenotipos presente en ssk1 msb2 sho1 opy2 frente a cek1 hog1 indican funciones adi cionales y mecanismos de regulaci\u00f3n de los elementos de la parte superior de las rutas no presentes a nivel de las mapks.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Opy2, un nuevo elemento implicado en la se\u00f1alizaci\u00f3n v\u00edaquinasas de tipo map en el hongo pat\u00f3geno candida albicans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Opy2, un nuevo elemento implicado en la se\u00f1alizaci\u00f3n v\u00edaquinasas de tipo map en el hongo pat\u00f3geno candida albicans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Mar\u00eda Herrero De Dios <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Pla Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepcion Gil garcia <\/li>\n<li>Juan  Carlos Arg\u00ed\u00bcelles ord\u00f3\u00f1ez (vocal)<\/li>\n<li>Mar\u00eda  angeles De la torre ruiz (vocal)<\/li>\n<li>Jaime tom\u00e1s Correa bordes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Mar\u00eda Herrero De Dios En organismos pat\u00f3genos oportunistas para el hombre como candida albicans, la adaptaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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