{"id":114041,"date":"2013-10-04T00:00:00","date_gmt":"2013-10-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biomarcadores-predictores-de-preeclampsia-en-gestantes-con-factores-de-riesgo\/"},"modified":"2013-10-04T00:00:00","modified_gmt":"2013-10-04T00:00:00","slug":"biomarcadores-predictores-de-preeclampsia-en-gestantes-con-factores-de-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/biomarcadores-predictores-de-preeclampsia-en-gestantes-con-factores-de-riesgo\/","title":{"rendered":"Biomarcadores predictores de preeclampsia en gestantes con factores de riesgo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Martinez Ruiz <\/strong><\/h2>\n<p>En este trabajo se evalu\u00f3 la utilidad de una serie de marcadores: triglic\u00e9ridos, \u00e1cido \u00farico, forma soluble de la tiros\u00edn kinasa 1 (sflt-1), factor de crecimiento placentario (plgf), m\u00faltiplo de la mediana de la prote\u00edna plasm\u00e1tica a asociada al embarazo (mom papp-a), ant\u00edgeno s\u00e9rico ca125 (ca125), enzima convertidora de angiotensina (eca) y el estudio ecogr\u00e1fico doppler, como posibles predictores de preeclampsia en el primer y segundo trimestre de gestaci\u00f3n.  se incluyeron un total de 68 gestantes con &quot;riesgo a priori&quot; de desarrollar preeclampsia (diabetes mellitus tipo i, enfermedad renal preexistente, hipertensi\u00f3n cr\u00f3nica sin proteinuria, etc) y un grupo control. De esas 68 gestantes, 8 desarrollaron preeclampsia. La combinaci\u00f3n de marcadores m\u00e1s eficiente fue utilizando el plgf del primer trimestre con un punto de corte ?37,6 pg\/ml, un \u00edndice de resistencia ?0,7 y la eca? 40,4 u\/l del segundo trimestre, pudiendo predecir el 87,5% de las gestantes que desarrollar\u00edan preeclampsia.  palabras claves: preeclampsia, factor de crecimiento placentario, \u00edndice de resistencia, enzima convertidora e angiotensina.    this study evaluated the usefulness of several biomarkers: triglycerides, uric acid, soluble fms-like tyrosine kinase-1 (sflt-1), placental growth factor (plgf), multiple of the median of pregnancy associated plasma protein-a (papp-a mom), serum antigen ca125 (ca125), angiotensin converting enzyme (ace) and the doppler ultrasound as predictors of preeclampsia in the first and second trimester of pregnancy. we included a total of 68 pregnant women with &quot;a priori risk&quot; of develop preeclampsia (type i diabetes mellitus, preexisting renal disease, chronic hypertension without proteinuria, etc) and a control group. Of those 68 pregnant women, 8 developed preeclampsia. The most efficient combination of the studied biomarkers was the use of plgf in the first-trimester with a cut-off ?37.6 pg\/ml, a resistance index ?0.7 and ace ?40,4 u\/l in the second trimester which can predict 87,5% of pregnant women who develop preeclampsia.  keywords: preeclampsia, placental growth factor, resistance index, angiotensin converting enzyme. resumen la preeclampsia contin\u00faa siendo un problema obst\u00e9trico sin resolver que afecta al 2-8% de todos los embarazos y supone uno de los problemas asociados a la gestaci\u00f3n que mayor morbimortalidad materna y fetal causa en todo el mundo, especialmente cuando se trata de casos severos y\/o precoces. Hasta el momento la identificaci\u00f3n de los factores de riesgo es el \u00fanico m\u00e9todo de cribado para esta enfermedad.  en este trabajo se evalu\u00f3 la utilidad de una serie de marcadores: triglic\u00e9ridos, \u00e1cido \u00farico, forma soluble de la tiros\u00edn kinasa 1 (sflt-1), factor de crecimiento placentario (plgf), m\u00faltiplo de la mediana de la prote\u00edna plasm\u00e1tica a asociada al embarazo (mom papp-a), ant\u00edgeno s\u00e9rico ca125 (ca125), enzima convertidora de angiotensina (eca) y el estudio ecogr\u00e1fico doppler, como posibles predictores de preeclampsia en el primer y segundo trimestre de gestaci\u00f3n. Se estudi\u00f3 las combinaciones de marcadores m\u00e1s eficientes para la predicci\u00f3n de esta enfermedad, se analiz\u00f3 la asociaci\u00f3n del polimorfismo gen\u00e9tico de la eca y de la apolipoprote\u00edna e (apo e) con la preeclampsia y se compar\u00f3 los marcadores angiog\u00e9nicos (sflt-1 y plgf) entre embarazos \u00fanicos y m\u00faltiples en el primer y segundo trimestre de gestaci\u00f3n.  se incluyeron un total de 68 gestantes con &quot;riesgo a priori&quot; de desarrollar preeclampsia (diabetes mellitus tipo i, enfermedad renal preexistente, hipertensi\u00f3n cr\u00f3nica sin proteinuria, etc) y un grupo control. De esas 68 gestantes, 8 desarrollaron preeclampsia.  las conclusiones que se obtuvieron fueron las siguientes: de los marcadores estudiados como posibles predictores de preeclampsia en gestantes con factores de riesgo, han resultado de utilidad el plgf y el ratio sflt-1\/plgf en el primer trimestre y la eca en el segundo trimestre de gestaci\u00f3n. La combinaci\u00f3n de marcadores m\u00e1s eficiente fue utilizando el plgf del primer trimestre con un punto de corte ?37,6 pg\/ml, un \u00edndice de resistencia ?0,7 y la eca? 40,4 u\/l del segundo trimestre, pudiendo predecir el 87,5% de las gestantes que desarrollar\u00edan preeclampsia.  El estudio gen\u00e9tico mostr\u00f3 una asociaci\u00f3n del genotipo de la apo ?3\/?4 con el desarrollo de pe pero no con el polimorfismo gen\u00e9tico de la eca d\/d.  Se observaron diferencias significativas en los marcadores angiog\u00e9nicos entre embarazos \u00fanicos y m\u00faltiples en el primer y segundo trimestre de gestaci\u00f3n.  palabras claves: preeclampsia, factor de crecimiento placentario, \u00edndice de resistencia, enzima convertidora de angiotensina.  background preeclampsia still remains an unsolved obstetric problem that affects the 2-8% of all pregnancies and supposes to be one of the problems associated the most, with pregnancy. Moreover, preeclampsia increased the maternal and fetal morbidity and mortality worldwide, in severe and\/or premature cases specially. Up to now, the identification of risk factors is the only screening method for this disease. this study evaluated the usefulness of several biomarkers: triglycerides, uric acid, soluble fms-like tyrosine kinase-1 (sflt-1), placental growth factor (plgf), multiple of the median of pregnancy associated plasma protein-a (papp-a mom), serum antigen ca125 (ca125), angiotensin converting enzyme (ace) and the doppler ultrasound as predictors of preeclampsia in the first and second trimester of pregnancy. We studied the most efficient combinations of markers focused in the disease prediction. We analyzed the association of the ace gene polymorphism and the apolipoprotein e (apo e) with preeclampsia and we compared the angiogenic markers (sflt-1 and plgf) among single and multiple pregnancies, in the first and second trimester of gestation. we included a total of 68 pregnant women with &quot;a priori risk&quot; of develop preeclampsia (type i diabetes mellitus, preexisting renal disease, chronic hypertension without proteinuria, etc) and a control group. Of those 68 pregnant women, 8 developed preeclampsia.  the conclusions obtained were as follows: among the markers studied as possible predictors of preeclampsia in pregnant women with risk factors, have been observed to be useful, plgf and sflt-1\/plgf ratio in the first trimester and ace in the second trimester of pregnancy. the most efficient combination of the studied biomarkers was the use of plgf in the first-trimester with a cut-off ?37.6 pg\/ml, a resistance index ?0.7 and ace ?40.4 u\/l in the second trimester which can predict 87.5% of pregnant women who develop preeclampsia. Genetic studies demonstrated an association of apo ?3\/?4 genotype with the developing of pe, not in the case of ace d\/d genetic polymorphism. Significant differences were observed in angiogenic markers between single and multiple pregnancies in the first and second trimester of pregnancy.  keywords: preeclampsia, placental growth factor, resistance index, angiotensin converting enzyme.   resumen la preeclampsia contin\u00faa siendo un problema obst\u00e9trico sin resolver que afecta al 2-8% de todos los embarazos y supone uno de los problemas asociados a la gestaci\u00f3n que mayor morbimortalidad materna y fetal causa en todo el mundo, especialmente cuando se trata de casos severos y\/o precoces. Hasta el momento la identificaci\u00f3n de los factores de riesgo es el \u00fanico m\u00e9todo de cribado para esta enfermedad.  en este trabajo se evalu\u00f3 la utilidad de una serie de marcadores: triglic\u00e9ridos, \u00e1cido \u00farico, forma soluble de la tiros\u00edn kinasa 1 (sflt-1), factor de crecimiento placentario (plgf), m\u00faltiplo de la mediana de la prote\u00edna plasm\u00e1tica a asociada al embarazo (mom papp-a), ant\u00edgeno s\u00e9rico ca125 (ca125), enzima convertidora de angiotensina (eca) y el estudio ecogr\u00e1fico doppler, como posibles predictores de preeclampsia en el primer y segundo trimestre de gestaci\u00f3n. Se estudi\u00f3 las combinaciones de marcadores m\u00e1s eficientes para la predicci\u00f3n de esta enfermedad, se analiz\u00f3 la asociaci\u00f3n del polimorfismo gen\u00e9tico de la eca y de la apolipoprote\u00edna e (apo e) con la preeclampsia y se compar\u00f3 los marcadores angiog\u00e9nicos (sflt-1 y plgf) entre embarazos \u00fanicos y m\u00faltiples en el primer y segundo trimestre de gestaci\u00f3n.  se incluyeron un total de 68 gestantes con &quot;riesgo a priori&quot; de desarrollar preeclampsia (diabetes mellitus tipo i, enfermedad renal preexistente, hipertensi\u00f3n cr\u00f3nica sin proteinuria, etc) y un grupo control. De esas 68 gestantes, 8 desarrollaron preeclampsia.  las conclusiones que se obtuvieron fueron las siguientes: de los marcadores estudiados como posibles predictores de preeclampsia en gestantes con factores de riesgo, han resultado de utilidad el plgf y el ratio sflt-1\/plgf en el primer trimestre y la eca en el segundo trimestre de gestaci\u00f3n. La combinaci\u00f3n de marcadores m\u00e1s eficiente fue utilizando el plgf del primer trimestre con un punto de corte ?37,6 pg\/ml, un \u00edndice de resistencia ?0,7 y la eca? 40,4 u\/l del segundo trimestre, pudiendo predecir el 87,5% de las gestantes que desarrollar\u00edan preeclampsia.  El estudio gen\u00e9tico mostr\u00f3 una asociaci\u00f3n del genotipo de la apo ?3\/?4 con el desarrollo de pe pero no con el polimorfismo gen\u00e9tico de la eca d\/d.  Se observaron diferencias significativas en los marcadores angiog\u00e9nicos entre embarazos \u00fanicos y m\u00faltiples en el primer y segundo trimestre de gestaci\u00f3n.  palabras claves: preeclampsia, factor de crecimiento placentario, \u00edndice de resistencia, enzima convertidora de angiotensina.  background preeclampsia still remains an unsolved obstetric problem that affects the 2-8% of all pregnancies and supposes to be one of the problems associated the most, with pregnancy. Moreover, preeclampsia increased the maternal and fetal morbidity and mortality worldwide, in severe and\/or premature cases specially. Up to now, the identification of risk factors is the only screening method for this disease. this study evaluated the usefulness of several biomarkers: triglycerides, uric acid, soluble fms-like tyrosine kinase-1 (sflt-1), placental growth factor (plgf), multiple of the median of pregnancy associated plasma protein-a (papp-a mom), serum antigen ca125 (ca125), angiotensin converting enzyme (ace) and the doppler ultrasound as predictors of preeclampsia in the first and second trimester of pregnancy. We studied the most efficient combinations of markers focused in the disease prediction. We analyzed the association of the ace gene polymorphism and the apolipoprotein e (apo e) with preeclampsia and we compared the angiogenic markers (sflt-1 and plgf) among single and multiple pregnancies, in the first and second trimester of gestation. we included a total of 68 pregnant women with &quot;a priori risk&quot; of develop preeclampsia (type i diabetes mellitus, preexisting renal disease, chronic hypertension without proteinuria, etc) and a control group. Of those 68 pregnant women, 8 developed preeclampsia.  the conclusions obtained were as follows: among the markers studied as possible predictors of preeclampsia in pregnant women with risk factors, have been observed to be useful, plgf and sflt-1\/plgf ratio in the first trimester and ace in the second trimester of pregnancy. the most efficient combination of the studied biomarkers was the use of plgf in the first-trimester with a cut-off ?37.6 pg\/ml, a resistance index ?0.7 and ace ?40.4 u\/l in the second trimester which can predict 87.5% of pregnant women who develop preeclampsia. Genetic studies demonstrated an association of apo ?3\/?4 genotype with the developing of pe, not in the case of ace d\/d genetic polymorphism. Significant differences were observed in angiogenic markers between single and multiple pregnancies in the first and second trimester of pregnancy.  keywords: preeclampsia, placental growth factor, resistance index, angiotensin converting enzyme.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biomarcadores predictores de preeclampsia en gestantes con factores de riesgo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biomarcadores predictores de preeclampsia en gestantes con factores de riesgo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Martinez Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/04\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Tovar Zapata<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Luisa Vargas alvarez-castellanos <\/li>\n<li>angel Gil izquierdo (vocal)<\/li>\n<li>Francisco Ca\u00f1izares hernandez (vocal)<\/li>\n<li>Jos\u00e9 Abellan aleman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Martinez Ruiz En este trabajo se evalu\u00f3 la utilidad de una serie de marcadores: triglic\u00e9ridos, \u00e1cido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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