{"id":114083,"date":"2018-03-11T10:41:54","date_gmt":"2018-03-11T10:41:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-de-la-respuesta-inflamatoria-esplacnica-secundaria-a-la-colestasis-microquirurgica-experimental\/"},"modified":"2018-03-11T10:41:54","modified_gmt":"2018-03-11T10:41:54","slug":"tratamiento-de-la-respuesta-inflamatoria-esplacnica-secundaria-a-la-colestasis-microquirurgica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/tratamiento-de-la-respuesta-inflamatoria-esplacnica-secundaria-a-la-colestasis-microquirurgica-experimental\/","title":{"rendered":"Tratamiento de la respuesta inflamatoria espl\u00e1cnica secundaria a la colestasis microquir\u00fargica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Losada Ruiz <\/strong><\/h2>\n<p>Introducci\u00f3n. En la inducci\u00f3n de cirrosis hep\u00e1tica mediante un modelo experimental microquir\u00fargico de colestasis extrahep\u00e1tica, la administraci\u00f3n de ketotif\u00e9n, un f\u00e1rmaco estabilizador de c\u00e9lulas cebadas, disminuir\u00eda la liberaci\u00f3n hepato-intestinal de mediadores inflamatorios y profibrog\u00e9nicos, consiguiendo as\u00ed reducir tanto la respuesta inflamatoria espl\u00e1cnica como la fibrosis biliar secundaria a colestasis. material y m\u00e9todos. Se han estudiado en ratas wistar pseudo-operadas y con colestasis extrahep\u00e1tica microquir\u00fargica la presencia de ascitis, de vasculopat\u00eda venosa mesent\u00e9rica, de hipertensi\u00f3n portal y el desarrollo de circulaci\u00f3n colateral portosist\u00e9mica. Se cuantificaron las concentraciones s\u00e9ricas de par\u00e1metros de funci\u00f3n hepato-biliar, as\u00ed como los niveles de mediadores pro- y anti-inflamatorios. Por \u00faltimo, se realiz\u00f3 un estudio histopatol\u00f3gico hep\u00e1tico para cuantificar el \u00e1rea de fibrosis hep\u00e1tica. Los mismos par\u00e1metros se evaluaron en ratas que se sacrificaron a las 6 semanas de su operaci\u00f3n y en un tercer grupo de ratas a las que se administr\u00f3 ketotif\u00e9n desde la sexta semana postoperatoria de la intervenci\u00f3n hasta su sacrificio. resultados. La administraci\u00f3n de ketotif\u00e9n reduce la relaci\u00f3n peso espl\u00e9nico peso corporal en las ratas con colestasis, produce una recuperaci\u00f3n del peso testicular, disminuci\u00f3n del desarrollo de circulaci\u00f3n esplenorrenal y pararrectal y de vasculopat\u00eda venosa mesent\u00e9rica, el aumento en los niveles s\u00e9ricos de transaminasa glut\u00e1mico pir\u00favica es inferior cuando se administra ketotif\u00e9n y los niveles de lipoprote\u00ednas de alta densidad mayores. los niveles s\u00e9ricos de creatinina disminuyen en las ratas tratadas con ketotif\u00e9n. ketotif\u00e9n disminuy\u00f3 los niveles en el h\u00edgado, \u00edleon y ganglios mesent\u00e9ricos de prote\u00edna quimioatrayente de macr\u00f3fagos 1 y factor de crecimiento de endotelio vascular y tnf- solo en h\u00edgado e \u00edleon. La concentraci\u00f3n de catalasa en el \u00edleon sufri\u00f3 un descenso. conclusi\u00f3n. El tratamiento anti-inflamatorio con ketotif\u00e9n podr\u00eda ser de utilidad para reducir las complicaciones secundarias a las hepatopat\u00edas cr\u00f3nicas. palabras clave. Colestasis, microcirug\u00eda, hipertensi\u00f3n portal, ascitis, inflamaci\u00f3n, c\u00e9lulas cebadas, ketotif\u00e9n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento de la respuesta inflamatoria espl\u00e1cnica secundaria a la colestasis microquir\u00fargica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento de la respuesta inflamatoria espl\u00e1cnica secundaria a la colestasis microquir\u00fargica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Losada Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/04\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Angeles Alller Reyero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias p\u00e9rez <\/li>\n<li>\u00e1ngel Su\u00e1rez Garc\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez montes (vocal)<\/li>\n<li>Manuel Dur\u00e1n poveda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Losada Ruiz Introducci\u00f3n. En la inducci\u00f3n de cirrosis hep\u00e1tica mediante un modelo experimental microquir\u00fargico de colestasis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[141,986],"tags":[37207,22643,3775,84006,226297,12620],"class_list":["post-114083","post","type-post","status-publish","format-standard","hentry","category-cirugia","category-complutense-de-madrid","tag-angel-suarez-garcia","tag-jaime-arias-perez","tag-jose-antonio-rodriguez-montes","tag-manuel-duran-poveda","tag-manuel-losada-ruiz","tag-maria-angeles-alller-reyero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/114083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=114083"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/114083\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=114083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=114083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=114083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}