{"id":114116,"date":"2018-03-11T10:41:59","date_gmt":"2018-03-11T10:41:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/123-triazoles-134-y-145-trisustituidos-sa%c2%adntesis-y-aplicacion-a-la-preparacion-de-contrastes-radiologicos-peptidomimeticos-osteogenicos-y-carbenos-mesoionicos-quirales\/"},"modified":"2018-03-11T10:41:59","modified_gmt":"2018-03-11T10:41:59","slug":"123-triazoles-134-y-145-trisustituidos-sa%c2%adntesis-y-aplicacion-a-la-preparacion-de-contrastes-radiologicos-peptidomimeticos-osteogenicos-y-carbenos-mesoionicos-quirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-coordinados\/123-triazoles-134-y-145-trisustituidos-sa%c2%adntesis-y-aplicacion-a-la-preparacion-de-contrastes-radiologicos-peptidomimeticos-osteogenicos-y-carbenos-mesoionicos-quirales\/","title":{"rendered":"1,2,3-triazoles 1,3,4- y 1,4,5-trisustituidos. s\u00edntesis y aplicaci\u00f3n a la preparaci\u00f3n de contrastes radiol\u00f3gicos, peptidomim\u00e9ticos osteog\u00e9nicos y carbenos mesoi\u00f3nicos quirales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Maialen Sagartzazu Aizpurua <\/strong><\/h2>\n<p>La tesis describe la preparaci\u00f3n de tres series de compuestos caracterizados por la presencia de n\u00facleos de 1,2,3-triazol 1,4,5- o 1.3.4-trusustituidos que presentan aplicaciones en el campo de los peptidomim\u00e9ticos y de los ligandos carb\u00e9nicos n-heteroc\u00edclicos.La primera serie comprende peptidomim\u00e9ticos yodados de rgd, uno de los cuales ha demostrado ser un excelente contraste radiol\u00f3gico en tomograf\u00eda computarizada multicorte (tcmc) en muestras de adenocarcinoma de colon cc531 implantando en h\u00edgado de rata.La segunda serie consta de peptidomim\u00e9ticos osteot\u00e9icos de rgd y ogp 10-14 conteniendo. Un fragmento espaciador activado mediante un grupo acido que permite su anclaje en la superficie de poli(\u00e9ter-\u00e9ter-cetona) (peek) dot\u00e1ndola de capacidad osteog\u00e9nica.Finalmente, se han sintetizado sales de n-alqui.-4,4\u00c2\u00bf-bis(1,2.3-triazolio) monosustituidas y disustituidas con control posicional en los \u00e1tomos de nitr\u00f3geno n3 y n3\u00c2\u00bf. Adem\u00e1s, dichas sales se han empleado para preparar dicarbenos de tipo 3,3\u00c2\u00bf-dimetil-4,4\u00c2\u00bf-bis(1,2,3-triazol)-5,5\u00c2\u00bf-diilideno con un eje de quiralidad axial estable en sus complejos de pata (i) y rodio (i).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>1,2,3-triazoles 1,3,4- y 1,4,5-trisustituidos. s\u00edntesis y aplicaci\u00f3n a la preparaci\u00f3n de contrastes radiol\u00f3gicos, peptidomim\u00e9ticos osteog\u00e9nicos y carbenos mesoi\u00f3nicos quirales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 1,2,3-triazoles 1,3,4- y 1,4,5-trisustituidos. s\u00edntesis y aplicaci\u00f3n a la preparaci\u00f3n de contrastes radiol\u00f3gicos, peptidomim\u00e9ticos osteog\u00e9nicos y carbenos mesoi\u00f3nicos quirales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Maialen Sagartzazu Aizpurua <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/04\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Mar\u00eda Aizpurua Iparraguirre<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Oyarbide garmendia <\/li>\n<li>gregorio Guisado barrios (vocal)<\/li>\n<li>eva Garc\u00eda lecina (vocal)<\/li>\n<li>Jes\u00fas Garcia castillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maialen Sagartzazu Aizpurua La tesis describe la preparaci\u00f3n de tres series de compuestos caracterizados por la presencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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