{"id":114205,"date":"2018-03-11T10:42:05","date_gmt":"2018-03-11T10:42:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nanostructured-lipid-carriers-as-vehicles-for-the-delivery-of-poorly-water-soluble-drugs\/"},"modified":"2018-03-11T10:42:05","modified_gmt":"2018-03-11T10:42:05","slug":"nanostructured-lipid-carriers-as-vehicles-for-the-delivery-of-poorly-water-soluble-drugs","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/nanostructured-lipid-carriers-as-vehicles-for-the-delivery-of-poorly-water-soluble-drugs\/","title":{"rendered":"Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Beloqui Garcia <\/strong><\/h2>\n<p>El objetivo de esta tesis ha sido el desarrollo de una formulaci\u00f3n basada en nlcs para la administraci\u00f3n de f\u00e1rmacos poco solubles, tanto por v\u00eda oral como por v\u00eda intravenosa. Para ello: 1.\tSe ha llevado a cabo la evaluaci\u00f3n de la distribuci\u00f3n en tejidos de tres formulaciones basadas en nlcs tras su administraci\u00f3n intravenosa a ratas con el fin de conocer la implicaci\u00f3n de las caracter\u00edsticas fisicoqu\u00edmicas en la biodistribuci\u00f3n de estas nanopart\u00edculas. 2.\tSe ha investigado el potencial de las nlcs para la administraci\u00f3n oral de f\u00e1rmacos poco solubles. Para ello, se encapsul\u00f3 espironolactona, un f\u00e1rmaco con baja solubilidad, y se estudi\u00f3 el comportamiento farmacocin\u00e9tico del f\u00e1rmaco encapsulado en nlcs in vivo en conejos y la biodistribuci\u00f3n de las mismas en ratas. 2.\tSe ha estudiado el mecanismo de transporte de las nlcs a trav\u00e9s de la barrera intestinal. Para ello se encapsul\u00f3 saquinavir, un f\u00e1rmaco clase iv seg\u00fan la clasificaci\u00f3n biofarmac\u00e9utica, y se estudi\u00f3 su permeabilidad a trav\u00e9s de modelos in vitro de enterocitos y c\u00e9lulas m.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Beloqui Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/05\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aaangeles Solinis Aspiazu<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Mar\u00eda Evora Garc\u00eda <\/li>\n<li>Antonio  Jos\u00e9 Leit\u00ed\u00a2o das neves almeida (vocal)<\/li>\n<li>rosa Mar\u00eda Hernandez martin (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Garrido cid (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Beloqui Garcia El objetivo de esta tesis ha sido el desarrollo de una formulaci\u00f3n basada en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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