{"id":114229,"date":"2018-03-11T10:42:09","date_gmt":"2018-03-11T10:42:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-vitamina-b12-en-la-actividad-de-una-familia-de-factores-transcripcionales-con-una-singular-arquitectura-de-dominios\/"},"modified":"2018-03-11T10:42:09","modified_gmt":"2018-03-11T10:42:09","slug":"papel-de-la-vitamina-b12-en-la-actividad-de-una-familia-de-factores-transcripcionales-con-una-singular-arquitectura-de-dominios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/papel-de-la-vitamina-b12-en-la-actividad-de-una-familia-de-factores-transcripcionales-con-una-singular-arquitectura-de-dominios\/","title":{"rendered":"Papel de la vitamina b12 en la actividad de una familia de factores transcripcionales con una singular arquitectura de dominios."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Manuel Ortiz Guerrero <\/strong><\/h2>\n<p>La bacteria myxococcus xanthus, responde a la luz azul produciendo carotenoides que la protegen del da\u00f1o fotooxidativo. En oscuridad la transcripci\u00f3n de la mayor\u00eda de los genes implicados en la s\u00edntesis de estos pigmentos es reprimida por las prote\u00ednas cara y carh, par\u00e1logas y funcionalmente redundantes. Ambas contienen un dominio n-terminal y otro c-terminal de uni\u00f3n al dna y a cobalaminas respectivamente. Sorprendentemente, carh, pero no cara, depende de b12 para llevar a cabo su funci\u00f3n represora. En este trabajo se ha demostrado que carh y su hom\u00f3logo en thermus thermophilus (ttcarh) son fotorreceptores que utilizan la adenosilcobalmina (forma de cobalamina) como grupo crom\u00f3foro. La luz desmantela la oligomerizaci\u00f3n de estas prote\u00ednas y su uni\u00f3n al dna inducidas por la adenosilcobalamina, lo que activa la expresi\u00f3n de los genes implicados en la carotenog\u00e9nesis. Este hallazgo ha sido publicado en la prestigiosa revista pnas (ortiz-guerrero et al. 2011).  palabras clave: b12 | myxococcus xanthus | carotenoides | fotorreceptor |  the bacteria myxocccus xanthus responds to light by producing carotenoid, protecting itself against photooxidative damage. In the dark, most of the genes involved in carotenoid synthesis are repressed by the paralogous and functionally redundant proteins cara and carh. Both of them contain a dna-binding n-terminal domain and a cobalamin-binding c-terminal domain. Surprisingly, carh, but not cara, repressive depends on b12. In this work we showed that carh and its homologous in thermus thermophilus (ttcarh) are photoreceptors in which adenosylcobalamin plays the role of a chromophore. Light dismantles carh and ttcarh adenosylcobalamine-induced oligomerization and dna binding, activating structural genes involved in carotenoid. This finding has been reported in the prestigious journal pnas (ortiz-guerrero et al. 2011)  key words: b12 | myxococcus xanthus | carotenoids | photoreceptor |<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la vitamina b12 en la actividad de una familia de factores transcripcionales con una singular arquitectura de dominios.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la vitamina b12 en la actividad de una familia de factores transcripcionales con una singular arquitectura de dominios. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Manuel Ortiz Guerrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Subramanian Padmanabhan Iyer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosa Mar\u00eda Ruiz vazquez <\/li>\n<li>Mar\u00eda rosa Ponce molet (vocal)<\/li>\n<li>douglas Laurents (vocal)<\/li>\n<li>eduardo Diaz fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Manuel Ortiz Guerrero La bacteria myxococcus xanthus, responde a la luz azul produciendo carotenoides que la 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