{"id":114271,"date":"2013-11-06T00:00:00","date_gmt":"2013-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-estimulacion-cognitiva-en-la-enfermedad-de-alzheimer-implicacion-de-bdnf\/"},"modified":"2013-11-06T00:00:00","modified_gmt":"2013-11-06T00:00:00","slug":"efectos-de-la-estimulacion-cognitiva-en-la-enfermedad-de-alzheimer-implicacion-de-bdnf","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/efectos-de-la-estimulacion-cognitiva-en-la-enfermedad-de-alzheimer-implicacion-de-bdnf\/","title":{"rendered":"Efectos de la estimulaci\u00f3n cognitiva en la enfermedad de alzheimer: implicaci\u00f3n de bdnf"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gorka Guere\u00f1u Lopetegui <\/strong><\/h2>\n<p>Education and cognitive occupations is commonly associated to reduced risk of alzheimer\u00c2\u00bfs disease (ad) dementia. Animal studies have demonstrated that cognitive stimulation (cs) achieved by social\/physical activities and\/or enriched environments compensates for memory decline. We have elaborated a novel paradigm of cs that is devoid of physical\/social activity and enriched environments. 4 months-old tg2576 mice were cognitively trained for 8 weeks and, after a break of 8 months, long-lasting effects of cs on cognitive abilities and ad-like pathology were measured. Mwm and nor tests showed that deficits in spatial and recognition memories were compensated by cs. These outcomes were accompanied by increased levels of hippocampal post-synaptic markers (psd95 and nr1) and proteins involved in synaptic formation (arc, \u00ed\u00a2-catenin). Cs softened amyloid pathology in terms of reduced levels of a\u00ed\u00a21-42 and the dodecameric assembly, referred as a\u00ed\u00a2*56. Cs appeared to affect the app processing since differences in levels of adam17, bace1 and c99\/c83 ratio were found. Tau hyper-phosphorylation and high activities of tau kinases were also reduced by cs. In contrast, cs did not induce any of these molecular changes in wild-type mice. The present findings suggest beneficial and long-lasting effects of cs early in life on cognitive decline and ad-like pathology. In this research work we have also characterized the role of bdnf on a new mechanism by which cognitive stimulation exerts its beneficial effects on cognitive decline and ad-like pathology.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la estimulaci\u00f3n cognitiva en la enfermedad de alzheimer: implicaci\u00f3n de bdnf<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la estimulaci\u00f3n cognitiva en la enfermedad de alzheimer: implicaci\u00f3n de bdnf <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gorka Guere\u00f1u Lopetegui <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Gil Bea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Franco fernandez <\/li>\n<li>pablo Mar\u00eda Mart\u00ednez-lage \u00e1lvarez (vocal)<\/li>\n<li>Elena Alberdi alfonso (vocal)<\/li>\n<li>Juan  Carlos Leza cerro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gorka Guere\u00f1u Lopetegui Education and cognitive occupations is commonly associated to reduced risk of alzheimer\u00c2\u00bfs disease (ad) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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