{"id":114391,"date":"2018-03-11T10:42:20","date_gmt":"2018-03-11T10:42:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-atorvastatina-en-pollos\/"},"modified":"2018-03-11T10:42:20","modified_gmt":"2018-03-11T10:42:20","slug":"estudio-farmacocinetico-de-atorvastatina-en-pollos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/estudio-farmacocinetico-de-atorvastatina-en-pollos\/","title":{"rendered":"Estudio farmacocinetico de atorvastatina en pollos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Celia Mar\u00eda Gonzalez Ponce <\/strong><\/h2>\n<p>Objetivo: se ha estudiado el comportamiento cin\u00e9tico de atorvastatina en pollos tras la administraci\u00f3n por las v\u00edas intravenosa y oral de una dosis de 3 mg\/kg de este f\u00e1rmaco hipolipemiante, con el fin de validar la dosis a utilizar en el biomodelo animal utilizado. m\u00e9todos: la determinaci\u00f3n de atorvastatina en plasma se realiz\u00f3 mediante hplc con detecci\u00f3n ultravioleta, siguiendo el m\u00e9todo descrito por siefert (1999), modificado para atorvastatina. El ajuste a m\u00e9todos farmacocin\u00e9ticos compartimentales y no compartimentales se realiz\u00f3 mediante el programa winnonlin professional\u00c2\u00bf. El criterio utilizado para determinar cu\u00e1l era la ecuaci\u00f3n que mejor describ\u00eda la evoluci\u00f3n de los datos experimentales en cada caso, fue el criterio de informaci\u00f3n de akaike (aic) (yamaoka et al., 1978). resultados: tras la administraci\u00f3n intravenosa, atorvastatina se distribuye seg\u00fan un modelo bicompartimental abierto, a diferencia del modelo monocompartimental descrito para la v\u00eda oral. Tras la administraci\u00f3n intravenosa, la vida media obtenida para el atorvastatina (t1\/2?Z) fue de 4,85 h con un tiempo medio de residencia (mrt) de 10,69 h. Los vol\u00famenes aparentes de distribuci\u00f3n calculados en funci\u00f3n del \u00e1rea bajo la curva (vz) y en estado estacionario (vss) resultaron ser de 0,60 l\/kg y 0,32 l\/kg respectivamente, indicando una amplia distribuci\u00f3n org\u00e1nica. En cuanto al aclaramiento plasm\u00e1tico (cl), \u00e9ste alcanz\u00f3 un valor de 30.99 ml\/kgoh. por v\u00eda extravascular, cuando se administr\u00f3 atorvastatina por v\u00eda oral, se registraron los siguientes tiempos de vida media: 17,54 h con un valor de mrt de 26,03 horas.  conclusiones: la biodisponibilidad de atorvastatina cuando se administr\u00f3 por v\u00eda oral alcanz\u00f3 un valor de 93.38 %.  en el estudio del descenso de los perfiles lip\u00eddicos en pollos tratados con atorvastatina,  los resultados anal\u00edticos de los par\u00e1metros lip\u00eddicos del plasma en los grupos experimentales dieron como resultado una disminuci\u00f3n del 33 % de los niveles de colesterol total en el grupo tratado con atorvastatina respecto al grupo control aterog\u00e9nico.   objetive: pharmacokinetics of atorvastatin was studied following intravenous and oral administration of single doses of 3 mg\/kg to chickens. methods: plasma concentrations were determined by hplc assay with ultraviolet detection following the method described by siefert et al(1999) modified for atorvastatin. The fitting to compartmental and non compartmental pharmacokinetic methods was carried out by using winnonlin professional\u00c2\u00bf computer programmes. The akaike&apos;s information criterion (aic) (yamaoka et al., 1978) was used to select the best equation that defines plasma concentration-time data for each animal.  results: the atorvastatin plasma concentration is distributed by a two compartment open model for intravenous dosing, unlike one-compartment model that could best be described for oral administration.  the atorvastatin terminal half-life (t\u00c2\u00bfz) was 4.85 h after intravenous administration, with a mean residence time (mrt) of 10.69 h. The apparent volumes of distribution calculated by the area method (vz) and at steady-state (vss) were 0.60 and 0,32 l\/kg, respectively, indicating a wide body distribution. Total body clearance was 30.99 ml\/kgoh. after extravascular administrations, terminal half-lives was 17.54 h. Mrt value obtained was 26.03 h. conclusion: absolute bioavailability was 93.38 % after atorvastatin oral administration.  pharmacokinetic values obtained in this work confirm the validity of the animal model (chickens fed hypercholesterolemic diets to induce atherosclerosis) and make it suitable for atorvastatin intervention studies. The biodisponibility value near to 100% makes it possible to use its own dosage regimen, avoiding extrapolation from human dosage. \twe can see as well that the values of serum total cholesterol decrease in 33% in the group treated with atorvastatin versus those fed hypercholesterolemic diets.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico de atorvastatina en pollos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico de atorvastatina en pollos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Celia Mar\u00eda Gonzalez Ponce <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Ayala De La Pe\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e1ndido Guti\u00e9rrez panizo <\/li>\n<li>Ana Aranda garcia (vocal)<\/li>\n<li>Miguel angel Domingo ruiz (vocal)<\/li>\n<li>Alberto Espuny miro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Celia Mar\u00eda Gonzalez Ponce Objetivo: se ha estudiado el comportamiento cin\u00e9tico de atorvastatina en pollos tras la 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