{"id":114424,"date":"2013-03-07T00:00:00","date_gmt":"2013-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-biomarcadores-en-la-estratificacion-de-riesgo-de-los-pacientes-con-sa%c2%adndrome-coronario-agudo-sin-elevacion-del-segmento-st\/"},"modified":"2013-03-07T00:00:00","modified_gmt":"2013-03-07T00:00:00","slug":"valor-pronostico-de-biomarcadores-en-la-estratificacion-de-riesgo-de-los-pacientes-con-sa%c2%adndrome-coronario-agudo-sin-elevacion-del-segmento-st","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cardiologia\/valor-pronostico-de-biomarcadores-en-la-estratificacion-de-riesgo-de-los-pacientes-con-sa%c2%adndrome-coronario-agudo-sin-elevacion-del-segmento-st\/","title":{"rendered":"Valor pron\u00f3stico de biomarcadores en la estratificaci\u00f3n de riesgo de los pacientes con s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Antonio Lopez Cuenca <\/strong><\/h2>\n<p>Resumen castellano: el s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st (scasest) es una condici\u00f3n inestable que predispone a recurrencias isqu\u00e9micas. El tratamiento antitromb\u00f3tico y la revascularizaci\u00f3n pretenden reducir tales complicaciones pero conllevan un incremento del riesgo de sangrado. Por tanto, la estratificaci\u00f3n del riesgo isqu\u00e9mico y hemorr\u00e1gico es fundamental. Nuestro objetivo fue valorar si los biomarcadores inflamatorios (interleucina-6 y prote\u00edna c reactiva) y los par\u00e1metros de funci\u00f3n renal (?-Traza prote\u00edna y cistatina c) son \u00fatiles en este proceso. Nuestros pacientes con scasest fueron seguidos al menos durante 12 meses. Mostramos que los niveles seriados elevados de interleucina-6 incrementaban el riesgo de muerte, infarto de miocardio e insuficiencia cardiaca. Adem\u00e1s, los niveles basales elevados de los biomarcadores renales se asociaron con un mayor riesgo de muerte y hemorragias mayores a largo plazo. En conclusi\u00f3n, el uso de interleucina-6, ?-Traza prote\u00edna y cistatina c mejora la estratificaci\u00f3n pron\u00f3stica de nuestros pacientes con scasest.   \tpalabras clave:  ?-Traza prote\u00edna, cistatina c, interleucina-6, prote\u00edna c reactiva, s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st.   non st-segment acute coronary syndrome (nste-acs) is an unstable coronary condition prone to ischemic recurrences in the long-term. Antithrombotic pharmacological treatments as well as various strategies for coronary revascularization are directed to reduce such complications but increase the risk of hemorrhagic complications. Thus, ischemic and hemorrhagic risk stratification is essential. Our aim was to asses if inflammatory biomarkers (interleukin-6 and c-reactive protein) and novel renal function parameters (?-Trace protein and cystatin c) are useful in this process. Our cohort of nste-acs patients was followed up for at least 12 months. We found that high serial interleukin-6 levels were associated with a greater risk of death, myocardial infarction and acute heart failure. Furthermore, high basal levels of ?-Trace protein and cystatin c were associated with a greater risk of death and major bleeding in the long-term. In conclusion, interleukin-6, ?-Trace protein and cystatin c levels improve prognostic stratification of nste-acs patients.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de biomarcadores en la estratificaci\u00f3n de riesgo de los pacientes con s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de biomarcadores en la estratificaci\u00f3n de riesgo de los pacientes con s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Antonio Lopez Cuenca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sergio Manzano Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Bertomeu Martinez <\/li>\n<li>vicente Bodi peris (vocal)<\/li>\n<li>arcadio Garcia alberola (vocal)<\/li>\n<li>Juan  Miguel Ruiz nodar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Antonio Lopez Cuenca Resumen castellano: el s\u00edndrome coronario agudo sin elevaci\u00f3n del segmento st (scasest) es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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