{"id":114502,"date":"2013-12-07T00:00:00","date_gmt":"2013-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-flavonoides-sobre-un-modelo-de-obesidad-en-ratones-db-db\/"},"modified":"2013-12-07T00:00:00","modified_gmt":"2013-12-07T00:00:00","slug":"efecto-de-flavonoides-sobre-un-modelo-de-obesidad-en-ratones-db-db","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-animal\/efecto-de-flavonoides-sobre-un-modelo-de-obesidad-en-ratones-db-db\/","title":{"rendered":"Efecto de flavonoides sobre un modelo de obesidad en ratones db\/db."},"content":{"rendered":"

Tesis doctoral de Olga Mar\u00eda Garcia Molina <\/strong><\/h2>\n

"efecto de flavonoides sobre un modelo de obesidad en ratones db\/db" resumen objetivos: la obesidad es una enfermedad que su preValencia ha ido aumentando en las \u00faltimas d\u00e9cadas. Son bien conocidas las consecuencias del exceso de peso sobre el sistema cardiovascular, digestivo, osteoarticular, endocrino-metab\u00f3lico y algunos tipos de c\u00e1ncer. Los flavonoides han demostrado en diversos estudios propiedades beneficiosas para la salud que incluyen, entre otros, efectos antiinflamatorios, antidiab\u00e9ticos, antihipertensivos, cardioprotectores y antiobesidad. Nuestro objetivo general fue analizar el efecto de flavonoides en un modelo experimental de rat\u00f3n obeso. metodolog\u00eda: realizamos el estudio experimental con 60 ratones leprdb \/ db hembras (n=10) para conocer el efecto de 4 tipos de flavonoides: extracto de fresno (e. Fresno), extracto de spergularia (e. Spergularia), extracto de granada (e. Granada) y citrolive. El tratamiento con e. Fresno, e. Spergularia y e. Granada se administr\u00f3 en el pienso y la administraci\u00f3n de citrolive se realiz\u00f3 en el agua (po-citrolive) y de manera subcut\u00e1nea (sc-citrolive) durante 7 meses. Se determin\u00f3 el peso mensual y tensiones arteriales quincenales. Se analizaron los siguientes par\u00e1metros plasm\u00e1ticos: colesterol total, colesterol hdl (lipoprote\u00edna de alta densidad), triglic\u00e9ridos, adiponectina, tnf-? (Factor de necrosis tumoral alfa), homociste\u00edna, glucosa, hemoglobina glicosilada, insulina y par\u00e1metro homa-ir (homeostatic model assessment-resistencia a la insulina). Se llev\u00f3 a cabo el an\u00e1lisis histopatol\u00f3gico del h\u00edgado al final del experimento. Los datos fueron analizados mediante el programa estad\u00edstico anova spss v 21. resultados: en todos los grupos de tratamiento se observ\u00f3 una disminuci\u00f3n del peso de los animales respecto a los del grupo control, excepto para el grupo po-citrolive. Dicha disminuci\u00f3n se correlacion\u00f3 con un aumento mayor de adiponectina en los grupos tratados y menor tnf-? A nivel plasm\u00e1tico. El colesterol total plasm\u00e1tico fue menor en todos los grupos de tratamiento. La concentraci\u00f3n de triglic\u00e9ridos plasm\u00e1ticos result\u00f3 menor a los 7 meses de tratamiento en los grupos del e. Fresno, e. Spergularia y po-citrolive. Asimismo existi\u00f3 un descenso mayor de la tensi\u00f3n arterial sist\u00f3lica y diast\u00f3lica y de los niveles de homociste\u00edna en los grupos de tratamiento. Los niveles de glucosa y de hemoglobina glicosilada no se vieron reducidos por ning\u00fan tratamiento, excepto para el grupo del e. Fresno. Sin embargo los niveles de insulina y par\u00e1metro homa-ir de los grupos tratados fue menor, reflejando una menor resistencia a la insulina en los grupos tratados con flavonoides. La esteatosis hep\u00e1tica fue significativamente menor en todos los grupos de tratamiento (grado i en todos ellos, excepto en el grupo po-citrolive, que, como para el grupo control fue grado ii). Dichos datos demuestran el efecto beneficioso de la p\u00e9rdida de peso traducido en una menor hipertensi\u00f3n arterial, un mejor perfil lip\u00eddico y una menor esteatosis de los grupos tratados con flavonoides. "flavonoids effect in an obese mice model db\/db" abstract objectives: obesity is a disease whose prevalence has been increasing over recent decades. The consequences of being overweight on the cardiovascular, digestive, osteo-articular and endocrine-metabolic systems are well known, and the disease has been associated with several types of cancer. Meanwhile, studies have pointed to the beneficial effects of flavonoids, which may act as antiinflammatory, antidiabetic, antihypertensive and cardioprotective agents, and which possess anti-obesity properties. The general aim of the research described within was to analyse the effect of flavonoids in an experimental obese mouse model. methodoly: an experimental study was made using 60 female leprdb \/ db mice (n=10) to ascertain the effect of 4 types of flavonoid: ash extract (e. Fresno = ash e), spergularia extracto (spergularia e), pomegranate extract (pomegranate e), and citrolive. The three extracts were administered in the feed, while citrolive was provided in the water (po-citrolive) or subcutaneously (sc-citrolive) over a period of 7 months. The weight of the mice was determined monthly and the arterial tension every two weeks. The following parameters were analysed in plasma: total cholesterol, hdl (high-density lipoprotein) cholesterol, triglycerides, adiponectin, tnf-? (Tumor necrosis factor alpha), homocysteine, glucose, glycosylated haemoglobin, insulin and homa-ir (the homeostatic model assessment-insulin resistance). A histopathological analysis of the liver was made at the end of the experiment. The data were analyzed by the statistics program anova spss v 21. results: a decrease in weight was observed in the animals of all treatment groups compared with the control group, except in the case of po-citrolive. The decrease was related with an increase in adiponectin in the treated groups, accompanied by lower levels of plasma tnf-?. Total plasma cholesterol was lower in all the treatments, while, after 7 months of treatment, the ash e, spergularia e and po-citrolive groups showed lower serum triglyceride concentrations than the control group. The systolic and diastolic blood pressure values and homocystein levels were lower than the control group. Glucose and glycosylated haemoglobin were not affected by any treatment, except ash e. However, insulin levels and homa-ir were lower in the flavonoid-treated groups, reflecting a lower resistance to insulin. Hepatic steatosis was significantly lower in all the treated groups (grade 1 in all groups, except in the po-citrolive group, which showed the same level as the control group – grade ii). The data demonstrate the beneficial effect of weight loss – which translated into lower blood pressure, improved lipid profile and lower steatosis in the groups treated with flavonoids.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEfecto de flavonoides sobre un modelo de obesidad en ratones db\/db.<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de flavonoides sobre un modelo de obesidad en ratones db\/db. <\/li>\n
  • Autor:<\/strong>\u00a0 Olga Mar\u00eda Garcia Molina <\/li>\n
  • Universidad:<\/strong>\u00a0 Murcia<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2013<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Francisco Jos\u00e9 G\u00f3mez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: vicente Vicente ortega <\/li>\n
        • xavier Ca\u00f1as perea (vocal)<\/li>\n
        • Mar\u00eda Jos\u00e9 Garc\u00eda s\u00e1nchez (vocal)<\/li>\n
        • Mar\u00eda del carmen Sanchez alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

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