{"id":114533,"date":"2018-03-11T10:42:36","date_gmt":"2018-03-11T10:42:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluation-of-different-targets-in-postmortem-brain-of-schizophrenic-subjects-focus-on-the-endocannabinoid-system-and-the-5-ht-2a-mglu2-receptor-heterocomplex\/"},"modified":"2018-03-11T10:42:36","modified_gmt":"2018-03-11T10:42:36","slug":"evaluation-of-different-targets-in-postmortem-brain-of-schizophrenic-subjects-focus-on-the-endocannabinoid-system-and-the-5-ht-2a-mglu2-receptor-heterocomplex","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/evaluation-of-different-targets-in-postmortem-brain-of-schizophrenic-subjects-focus-on-the-endocannabinoid-system-and-the-5-ht-2a-mglu2-receptor-heterocomplex\/","title":{"rendered":"Evaluation of different targets in postmortem brain of schizophrenic subjects: focus on the endocannabinoid system and the 5-ht 2a\/mglu2 receptor heterocomplex."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Muguruza Millan <\/strong><\/h2>\n<p>La esquizofrenia es una enfermedad mental grave y discapacitante con una preValencia del 1% en la poblaci\u00f3n mundial. El tratamiento farmacol\u00f3gico del que se dispone hasta el momento no es eficaz en un alto porcentaje de pacientes. En este sentido, el estudio de las alteraciones moleculares en el cerebro postmortem de sujetos con esquizofrenia puede contribuir a la mejor comprensi\u00f3n de las bases etiopatol\u00f3gicas de esta enfermedad y al desarrollo de nuevas dianas terap\u00e9uticas. La presente tesis doctoral se ha centrado en la evaluaci\u00f3n del sistema cannabinoide end\u00f3geno (sce) y en el estatus de los receptores que conforman el heterocomplejo 5-ht2a\/mglu2 en el cerebro postmortem de sujetos con esquizofrenia y controles emparejados. El sce es un sistema neuromodulador que se ha visto previamente implicado en esquizofrenia. El presente trabajo muestra alteraciones en sentido opuesto en los niveles de los dos principales endocannabinoides (ec) en el cerebro de sujetos diagnosticados de esquizofrenia. Adem\u00e1s, aquellos individuos que presentaban toxicolog\u00eda positiva para antipsic\u00f3ticos en el momento del fallecimiento muestran en general menores concentraciones de ec que aquellos con toxicolog\u00eda negativa. No se han encontrado alteraciones significativas en otros elementos del sce como son la expresi\u00f3n g\u00e9nica o la funcionalidad del receptor cb1 o de las enzimas de degradaci\u00f3n faah y magl en la corteza prefrontal (cpf) de sujetos con esquizofrenia. Recientemente se ha descrito la existencia de un heterocomplejo funcional formado por los receptores 5-ht2a y mglu2. Ambos receptores se han implicado previamente en esquizofrenia. El presente estudio muestra un aumento de la densidad del receptor 5-ht2a en la cpf de sujetos esquizofr\u00e9nicos libres de tratamiento antipsic\u00f3tico pero no en aquellos que estaban tratados. Tambi\u00e9n se han observado alteraciones en el estado de alta afinidad para agonistas de ambos receptores en la cpf de sujetos con esquizofrenia independientemente del tratamiento con antipsic\u00f3ticos. Los resultados obtenidos demuestran adem\u00e1s una interacci\u00f3n farmacol\u00f3gica entre los receptores que comprenden el heter\u00f3mero 5-ht2a\/mglu2 en la cpf humana, estando esta interacci\u00f3n alterada en sujetos con esquizofrenia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluation of different targets in postmortem brain of schizophrenic subjects: focus on the endocannabinoid system and the 5-ht 2a\/mglu2 receptor heterocomplex.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluation of different targets in postmortem brain of schizophrenic subjects: focus on the endocannabinoid system and the 5-ht 2a\/mglu2 receptor heterocomplex. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Muguruza Millan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Felipe Callado Hernando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas andres Garcia sevilla <\/li>\n<li>Francisco Ciruela alf\u00e9rez (vocal)<\/li>\n<li>Antonio Rodriguez gaztelumendi (vocal)<\/li>\n<li>Elena Castro fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Muguruza Millan La esquizofrenia es una enfermedad mental grave y discapacitante con una preValencia del 1% [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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