{"id":114545,"date":"2018-03-11T10:42:36","date_gmt":"2018-03-11T10:42:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pharmacokinetic-pharmacodynamic-modelling-of-therapeutic-proteins\/"},"modified":"2018-03-11T10:42:36","modified_gmt":"2018-03-11T10:42:36","slug":"pharmacokinetic-pharmacodynamic-modelling-of-therapeutic-proteins","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/pharmacokinetic-pharmacodynamic-modelling-of-therapeutic-proteins\/","title":{"rendered":"Pharmacokinetic-pharmacodynamic modelling of therapeutic proteins"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Zinnia Patricia Parra Guill\u00e9n <\/strong><\/h2>\n<p>Pharmacokinetic\/pharmacodynamic modelling approach has proven to be an extremely valuable tool in the preclinical and clinical development of a wide range of drugs. However its application to biotechnological medicines, a recent but growing market, is still very scarce, especially at the preclinical level. In this thesis, three examples of mathematical models and their applicability to different therapeutic proteins at early preclinical stages will be given.  in chapter 1 an integrated pharmacokinetic\/pharmacodynamic (pk\/pd) model to describe and compare kinetic and dynamic behaviour of interferon (ifn) &#945; with a new developed fusion protein obtained by linking ifn&#945; to apo-ai is presented. Modelling approach enabled the integration of multiple information, as well as the identification and quantification of important differences in the in vivo behaviour of the molecules.  chapter 2 describes a target-mediated drug disposition model developed to jointly characterize interleukin 12 (il-12) kinetics and its relationship with ifn&#947;. The model was applied to propose an improved dosing regimen able to achieve sustained il-12 levels minimising the negative feedback triggered by ifn&#947;. the final case-study is included in chapters 3 and 4. First, a semi-mechanistic model accounting for the key biological mechanisms implied in the tumour response triggered by a novel vaccine is presented. In a second step, the model developed was expanded to characterize the pharmacodynamic effects triggered by two co-adjuvant therapies commonly used in combination therapies (cyclophosphamide and cpg).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Pharmacokinetic-pharmacodynamic modelling of therapeutic proteins<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Pharmacokinetic-pharmacodynamic modelling of therapeutic proteins <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Zinnia Patricia Parra Guill\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Fernandez De Troconiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Martinez lanao <\/li>\n<li>piet hein Van der graaf (vocal)<\/li>\n<li>laura Arribillaga arangoa (vocal)<\/li>\n<li>Jes\u00fas Giraldo arjonilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zinnia Patricia Parra Guill\u00e9n Pharmacokinetic\/pharmacodynamic modelling approach has proven to be an extremely valuable tool in the 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